The Ultimate Bone Broth, Gelatin, and Collagen Protein Guide

Bone broth, collagen, and gelatin, when considered as foods, contain very distinguished proteins.

You cannot get the benefits of these proteins by consuming any other foods.

In other words, it's impossible to get the benefits of bone broth protein, gelatin, or collagen, by eating fish, eggs, meat, grains, beans, legumes, shellfish, and other foodstuffs.

If you're thinking: "so I've been missing out all these years!?" then you're correct.

Don't worry.

By including some bone broth, collagen, or gelatin in your diet your life will only get better.

We've all made mistakes in managing our health in the past. I have made many mistakes in the past as well. It's not making mistakes that's bad, but it's not correcting the mistakes that should worry you.

The bright side is that including some bone broth, collagen, or gelatin is extremely easy.

You can have life-changing health benefits while saving money.

Really?

Yes...

Here's why...

The Ultimate Bone Broth, Gelatin, And Collagen Protein Guide

Take a look at these people:

maasai herders livestock for nutrition

They are the Maasai tribe in Africa.

When they kill one of their domesticated animals or a wild animal, what will they do?

Will they limit themselves to eating the meat - made of the muscles (and organs) of the animal?

No.

They use the entire animal. Using the entire animal means using the skin, bones, marrow, cartilage, joints, organs - and more. Not a single useful ingredient is discarded.

Many cultures are the same in using the entire animal. It doesn't matter whether you look at the Maasai in Africa, the native Americans in the US, or Eskimos in Canada. Looking from a historical perspective, all these cultures use(d) the entire animal after the kill,

In fact, their very survival depended on using the entire animal after a kill.

Why?

Almost all parts of an animal can be used for some purpose. So if you blatantly discard the bones, skin, and other connective tissue such as tendons, you're throwing away very useful parts. Throwing away useful parts makes survival more difficult.

Animal skin, for example, can be used for clothing, or as a blanket.

But what about the other parts?

You might not know that animals' connective tissues, bones, and joints can be used as food.

This blog post shows you exactly how and why such "leftovers" can be considered food.

In this sense, these traditional cultures are different than our society. These cultures treat connective tissues, bones, and joints very differently.

Our modern society undervalues - and therefore literally discards - many useful parts of animals.

Why?

Most people in modern societies are used to buying chicken fillets, pre-packaged fish, and ground beef in supermarkets.

Modern people only eat muscle meats (and very seldom organ meats).

And to make my claim even stronger: the few food choices probably occurred because people demand simple foods. In turn, most modern supermarket foods you can buy - even animal foods - require minimal preparation.

What's the downside?

Pre-packaged also makes you lose touch with your food.

Therefore, most people don't know that many other parts of animals have health benefits - such as connective tissue or bones - because they are disconnected from their food.

They are consequently missing an important dietary ingredient from the animal kingdom.

In this post, I'll explain why you need to consume these foods.

Yes, you need to include some bone broth, gelatin, or collagen into your diet. At least: if you want optimal health.

Why?

As much as 25-50% of all total proteins found in animals can be sourced from the connective tissues, joints, skin, and bones.^{[128; 129]}The same is true for you. In your body, the same proteins make up up about 90% of the of your tendons and ligaments, and 60-70% of your skin.

Eating that specific part of an animal can yield health benefits for the corresponding parts in your own body.

For example, the consumption of non-meat animal proteins can improve your skin, joints, and bones.

People living in modern society are missing out on these benefits.

How can you avoid missing out?

Integrate bone bone broth, gelatin, or collagen into your diet. Which option you choose is of less import. What matters is that you include at least one option.

Because this article is long, I've included a summary at the beginning of this article.

If you just want to understand the basics regarding bone broth, gelatin, and collagen protein, read the summary section. If you want to understand the ins and outs, read the entire article.

In the remainder of the article, I'll explain what bone broth, gelatin, and collagen are, and tell you about their differences.

You'll get to understand the benefits of consuming this food group, how to use this food group in your diet, and how to make bone broth yourself. I'll also give you tips on how to buy the highest-quality broth, gelatin, and collagen products.

Note: this blog post - like my previous blog posts - contains some nerd sections. These nerd sections contain more advanced explanations. You can skip these nerd sections if you just want to understand the basics about bone broth, gelatin, and collagen.

Ready?

Here we go. The ultimate bone broth, gelatin, and collagen guide...

Summary: Bone Broth, Gelatin, Collagen.
Introduction: Why You Need Bone Broth, Gelatin, Or Collagen
Differences Between Bone Broth, Gelatin, And Collagen.
Amino Acids In Bone Broth, Gelatin, And Collagen.
Shared Benefits Of Bone Broth, Gelatin, And Collagen
Specific Benefits of Bone Broth, Gelatin, or Collagen
How To Use Bone Broth, Gelatin, And Collagen.
Make Your Own Bone Broth
High-Quality Bone Broth, Gelatin, And Collagen Products
Conclusion: You Need Either Bone Broth, Gelatin, Or Collagen
Other Questions

Summary: Bone Broth, Gelatin, And Collagen

Note: by reading the summary, you'll only understand the bone broth, gelatin, and collagen basics.

Bone broth, gelatin, and collagen are three different - but related - foods. In a sense, these foods together make up their own very unique food group.

Let's first consider how these foods are made:

Bone broth is made by simmering animal bones for 2-48 hours, for example, in a pan, slow cooker, or pressure cooker.
Gelatin is extracted from the tendons, skin, bones, and ligaments of animals, after a treatment process.
Collagen can be seen as a purified extract of gelatin.

The reason you need to consume bone broth, gelatin, and collagen, is because they contain specific "amino acids" that are not found in large quantities in other foods.

You might ask: "what are amino acids?" Amino acids are the basic building blocks of proteins.

The proteins that you get from bone broth, gelatin, and collagen, are thus very different than the proteins in fish, shellfish, meat, eggs, and dairy. The reason for this difference is that bone broth, gelatin, and collagen contain other amino acids than your regular high-protein foods.

The main the benefits of consuming bone broth, gelatin, and collagen are:

improved skin, hair, nail, and bone health
better gut health and digestion
a stronger immune system
may help you cope with many diseases, such as autoimmune disease and obesity
deeper sleep and faster recovery from training sessions
improved joint functioning and flexibility

If you have to choose between bone broth, gelatin, and collagen, opt for bone broth.

Bone broth has additional advantages over the other two options. Examples of these benefits are additional benefits for your joints and skin.

If you want to know more about these foods, continue reading the full article.

If you just want to know how to make your own bone broth, scroll to section eight of this article. To see what gelatin and collagen products I recommend, go to section nine.

By the way, grab my 10 free tips on creating bone broth below:

Introduction: Why You Need Bone Broth, Gelatin, Or Collagen

What's my story with these foods?

I had been strength training about 10 years. I consumed fatty fish, and my eggs on almost a daily basis.

I ate my vegetables, some fruits, added healthy fats, and had meat.

Little did I know that I was missing a very important protein category in my diet: bone broth, gelatin, or collagen.

As stated in the introduction, this food group makes up as much as 50% of the proteins found in animals.

So, if you're eating meals like this:

paleo diet meal

And this:

another paleo diet meal that does not contain collagen nor gelatin

Then you're missing out on an entire important food group...

Don't worry...

I was missing out too.

I needed to add bone broth, gelatin, or collagen to my diet for optimal health.

As you will learn, bone broth, gelatin, and collagen, are really important for improving your gut health, skin quality, joints, and overall well-being.

But let's be real here.

Bone broth, or a gelatin supplement, are never going to make you fundamentally healthy, if more important health-fundamentals are not in order.

Why?

Well, if you're not getting exposed to any sunlight during the day, then exposing your eyes and skin to the sun should get you your top priority, instead of adding bone broth to your diet.
Alternatively, let's say you're ruining your sleep at night because you're around artificial light from televisions and smartphones. In that case, mitigating the damage of artificial light should assume your priority.

Let's say you're not exposing yourself to the sun, or still getting artificial light into your eyes after sunset. In that case, stop reading this article, and read the linked articles in the paragraphs above first.

Really.

The other articles give you information that is more important for your health.

Let me repeat: adding bone broth, gelatin, or collagen, can never compensate for making more fundamental mistakes in the management of your health.

So, let's return to my story...

What did I notice, after adding the food group treated in this article to my diet?

I mainly noticed improvements in the look of my skin, my flexibility, and general relaxation:

In terms of skin quality, I can really see and feel my skin quality become poorer when I run out of this food group. I'm thus always making sure to have some protein from this food group in stock.
The improvements in flexibility were really easy to measure for me, as I've been strength training for 15 years. Because of my experience, I notice even small differences in my movement capacity. Adding gelatin to my diet made me more flexible within 1 or 2 weeks.
Whenever I drink bone broth, the food really calms me down. Bone broth has now become one of my favorite foods to consume after dinner.

Now that you've heard my story, let's see how you can distinguish between bone broth, gelatin, and collagen.

Differences Between Bone Broth, Gelatin, And Collagen

The first food, bone broth, is the easiest to understand.

Bone broth is made by simmering animal bones for several hours in a liquid:

bones for making bone broth

What liquid?

Most people use tap water or spring water - while adding some vinegar - to simmer the bones.

You can use different types of animal bones: beef, fish, fowl, pig, and even game. The simmering period takes between two and 48 hours.

But why the big difference in hours?

The simmering period depends mostly on two things. First, the animal type, and secondly, the type of bone that you use. For example, very large cow bones need to simmer much longer than bones from small fish.

What to do when the broth is finished? Drink the broth.

Or use bone broth within a recipe:

liver in bone broth recipe

For example, bone broth can act as the basis for soups, or you can use bone broth in a stew.

So: bon appetit.

Secondly, there's gelatin. You might know gelatin as a key ingredient of pudding:

pudding made of gelatin

Gelatin is made by a "hydrolyzation" process of animal body parts that are high in certain proteins.^[114] These proteins are found in their skin, bones, tendons and joints. Hydrolization simply means that proteins are broken down over time.

Take the example of an animal hide. When producing gelatin, that animal hide is broken down through a chemical process. While that process takes time, eventually you will be able to extract the proteins from that hide.

(before you ask: no, these chemicals do not end up on in your food)

These resulting proteins are "gelatinous", meaning jelly-like or gel-like - which becomes our final product: gelatin.

Nowadays, gelatin is often seen as a mere by-product of leather products and meat. That reputation is unwarranted, however, as gelatin is highly nutritious.

Here you can see how modern society can be problematic: most people don't even know that gelatin exists, or that it is good for them.

Now that you understand how gelatin is created, let's see how gelatin is used as a basis for collagen.

Collagen: the third and last food.

You might have seen collagen as an ingredient on the labels of your beauty products. That's the kind of material I'm talking about here as well. Instead of using collagen on your skin, however, I'm treating collagen as an ingestible food.

Most collagen that's on the market today, is made out of an additional "hydrolyzation process" of gelatin. In other words, collagen is actually processed gelatin or gelatin that is broken down further.

That broken-down gelatin is often called "hydrolyzed collagen". To avoid confusion. I will refer to "hydrolyzed collagen" as "collagen" in the remainder of this article.

Overall, we thus end up with three sources within this protein food group:

Bone broth, made by simmering bones for several hours.
Gelatin, which is broken down from skin, connective tissue, joints, and bones.
Collagen, which is (further) processed gelatin.

There's no hard distinction to be made between gelatin and collagen. In general, however, collagen is seen as a more refined version of gelatin.

Gelatin is often more "rough", granulated, and unrefined, while collagen is more powdery, and pure.

Now that you understand the difference between these foods, let's look at what makes them special.

Amino Acids In Bone Broth, Gelatin, And Collagen

Bone broth, gelatin, and collagen, are exceptional because of the proteins that they contain.

Why?

Because of the specific "amino acids" found in these foods. You can see amino acids as the "building blocks" of proteins. All proteins are made up of different amino acids.

The reason bone broth, gelatin, and collagen are special, is that they contain amino acids that cannot be found in fish, meat, shellfish, dairy or eggs - at least, not in great quantities.

Your body can form the amino acids found in bone broth, gelatin, and collagen on its own. But the process by which your body produces these amino acids is very "expensive". In other words, converting your body's existing amino acids into the amino acids found in bone broth, gelatin, and collagen, costs a lot of energy.

That conversion is inefficient for your metabolism. As a result, you're better off when your body does not have to produce the amino acids contained in bone broth, gelatin, and collagen in the first place.

Besides costing energy for your metabolism, why should you consume these foods?

Because your body contains a lot of tissues that rely on their amino acids. About 20-40% of your body consists in amino acids that are found in bone broth, gelatin, and collagen.^{[84; 85; 86]}.

In fact, the amino acids found in bone broth, gelatin, and collagen, are the most abundant in the human body.

If you do not consume enough of these foods, you'll be more likely to be deficient.

Actually, lots of people in modern society are deficient.^[47]

But the problem gets worse: if you're diseased, it's even harder for your body to produce the amino acids from this food group.

Many people thus consume too little bone broth, gelatin, and collagen, even though they needs these foods - especially when diseased.

(Advanced explanation: The most important amino acids - which are contained in large quantities in bone broth, gelatin, and collagen - are:^[123]

1) glycine - makes up the greatest proportion of bone broth, gelatin, and collagen; important for your immune system, and cell stability^[122].

2) proline - takes up the second greatest proportion of bone broth, gelatin, and collagen. Important for your blood vessels, wound healing, antioxidant functions, and joint health.^[82]

3) hydroxyproline - keeps collagen stable.^[82]

Some people might consider glutamine a quintessential amino acids within bone broth, gelatin, and collagen. That conclusion is unwarranted, however, as other foods such as eggs and fish contain greater glutamine levels than bone broth, gelatin, and collagen. While glutamine is very important for gut function, I do not think glutamine is responsible for improving gut function within bone broth consumption.^{[130; 131; 132; 133; 134; 135; 136]} Other substances, such as glucosamine or gelatin, might be the reason bone broth benefits gut function.

In the remainder of this article, these amino acids will be treated as the core constituents of bone broth, gelatin, and collagen. I will not treat these amino acids separately).

The bottom line is that you need bone broth, gelatin, and collagen, for the specific proteins they contain.

Why?

Let's explore the benefits of these foods further.

Shared Benefits Of Bone Broth, Gelatin, And Collagen

Bone broth, collagen, and gelatin have lots of commonalities - in fact, they almost have the same benefits.

In this section, I'll give you the benefits that bone broth, collagen, and gelatin have in common. In the following section, we'll look at the specific benefits of bone broth, collagen, and gelatin products.

Why consume these foods?

The first benefit of this food group is that they improve gut function.

People who have gut issues also tend to be low on the proteins that are contained in bone broth, gelatin, and collagen.^{[10; 41; 81; 82]}

Why is that important?

Well, lots of people in modern society have trouble processing the food they eat. Lots of people also have gut problems. Gut issues:

Affect 3 to 25% of the world's population^{[2; 3; 4; 5]} That's 210 million to 1.75 billion people.
Are strongly associated with having poorer overall health^[6].
Have been connected to autoimmune disease.^{[155; 156; 157]}
Are tied to obesity.^{[158; 159]}
Connect to cognitive functioning, mental-well being and cognitive disease.^[163]
Can compromise your immune system, and may even contribute to cancer formation.^{[160; 161; 162]}

Fortunately, the consumption of bone broth, gelatin, and collagen, may help you repair your gut, if you have issues.^{[75; 76; 77; 78; 79]}

Let's be very clear here. I'm not saying that bone broth, gelatin, or collagen, will cure your gut issues once and for all.

What I'm saying is that they might be an amazing strategy to aid in the healing of your gut issues. Out of these three foods, most people report that bone broth is the easiest on their stomachs. If you have gut problems, you should try bone broth first.

Let's now look at other benefits that these foods have.

Bone broth, gelatin, and collagen greatly improve your skin condition.^{[11; 61; 62; 63; 64; 65; 66; 67; 68; 69; 70; 71; 72; 80]}

Remember that the proteins found in bone broth, gelatin, and collagen, are found almost everywhere in your body. These proteins are what keep your skin elastic, and your joints supple.

These proteins become less available during aging, which is one reason why your skin quality goes down over time.^[164] These foods can slow or even reverse that process.

Why?

Bone broth, gelatin, and collagen can improve your skin elasticity, reduce wrinkles, enhance hydration, lead to quicker wound healing, and improve the overall look of your skin.

However, the list of benefits of these foods grows much longer.

Bone broth, gelatin, and collagen:

decrease inflammation.^{[14; 15; 16; 17; 26; 31]} Inflammation lies at the basis of many modern diseases, such as autoimmune disease, heart disease, and problems in your gut.
may help treat heart disease.^{[22; 33; 34; 48]} For example, these foods may lower high blood pressure levels.
improve your immune system.^{[19; 20; 86]}
help you detox and improve antioxidant levels in your body.^{[21; 22; 23; 24; 28; 29; 30]}.
may enhance your liver function.^{[18; 29; 30; 41; 42; 43]}.
aid your weight loss.^{[25; 27; 127]}.
regulate your blood sugar levels.^{[14; 22; 35; 36; 37; 38; 39; 108]}. Regulating your blood sugar will not only help you if you have diabetes--as an athlete, for example, regulating blood sugar will help you lose more fat and build more muscle.
help you perform under stress.^[32] Bone broth, gelatin, and collagen, might even offset some of the effects of sleep deprivation.
protect bone density^[13], and keep your teeth healthy.^[46]
this food group might even slow your intoxication on alcohol.^[45]
make you feel better, combating, for example, feelings of depression.^{[49; 50; 51; 52; 53; 54; 55; 56; 57; 58]}
even helps your sleep quality.^{[59; 60; 61; 62; 63]}
lowers stress hormones.^[126]
and, finally, protect against sunburn.^[74]

As you can conclude, bone broth, gelatin, and collagen, affect many areas of your health.

infographic showing benefits of bone broth gelatin and collagen

The long list of benefits should give you an inkling as of why I consider this food group very important.

The list should also tell you why these foods are currently undervalued in our modern society.

Next, let's look at the specific benefits of each of these foods.

Specific Benefits Of Bone Broth, Gelatin, Or collagen

Instead of considering all the benefits that bone broth, gelatin, and collagen have in common, I'll now tell you about their differences.

Let's first consider bone broth.

Who does not enjoy a cup of bone broth during a cold winter evening?

bone broth picture

There's even a saying that bone broth will "resurrect the dead".

Why?

Bone broth is one of the major ways to improve your gut health.

Remember that if you have issues - such as a leaky gut - then bone broth is your top choice. I've stated before that gut function is very important for preventing disease.

But what other reasons that you have to care about gut health?

You need gut health to absorb the nutrients of the food you consume.^[8]

Bone broth can also reduce inflammation.^[7] Inflammation lies at the basis of many modern diseases. Inflammation is also a problem in an unhealthy digestive system.

Additionally, bone broth build the stomach lining and help with bile and acid production. Bone broth is thus great for your digestion. Many people with gut problems report feeling better on bone broth - so can you.

(Advanced explanation: What are some common gut problems? Bacterial overgrowth in the gut, Celiac disease, Lyme, inflammatory bowel syndrome, or a leaky gut. If you have gut issues, some of the names might sound familiar to you. Try bone broth.

Bone broth also contains other substances that aid your gut health, which are not found in gelatin or collagen.

The first substance is called "glucosamine".

You can forget that difficult name. What's important for you, is that the substance has these benefits:

Help your joints stay supple and healthy, while reducing joint pain.^{[138; 139; 140; 141; 142]}
Lower inflammation.^{[143; 144]}
Improves muscle mass gains when you have joint problems.^[144]
Builds and protects your cartilage.^{[145; 146]}
Makes your skin look great.^{[147; 148]}

Next, there's hyaluronic acid, which makes your skin look younger, and may protect your joints.^{[149; 150; 151; 152; 153]}

Ingredients like hyaluronic acid and glucosamine might make the difference between bone broth on the one hand, and gelatin or collagen on the other hand.

Bone broth is thus more of a "whole food" than gelatin or collagen.

You might also begin to see a pattern here: all foods described in this article - and especially bone broth - aid your joints, skin, and overall inflammation levels.

But you might be asking "are there any possible drawbacks to bone broth?"

Yes:

In theory, bone broth should be the easier on the body - specifically the digestive system - than gelatin and collagen. However, some people report that they tolerate collagen better than bone broth. You have to test what works best for you - bone broth or collagen.
Sometimes, animal bones are contaminated with toxins.^[9] Lead and cadmium are examples of such toxins. Make sure to use bones from healthy animals - such as grass-fed cows and pastured chickens - to minimize your risk for ingesting these toxins. The same is true for buying prioritizing organic--if you buy bones that come from cows that eat pesticide-sprayed food, then you'll end up ingesting these pesticides as well.

Any other key insights?

Yes...

Contrary to popular belief, bone broth is not very mineral-rich.^{[9, 137]}

Many people think that bone broth is very rich in phosophorus, calcium or magnesium. However, most minerals in bone broth originate from the vegetables that are added to the broth.

(You can click here for an excellent detailed analysis of that conclusion.)

Overall, bone broth might have possible drawbacks. But if used correctly, the food will have huge advantages for your health.

Let's now look at gelatin's and collagen's specific benefits

Remember from the introduction of this article, that gelatin basically consists in broken down skin, connective tissue, and bone from animals.

However, not much specific scientific research has been carried out on gelatin. We know, for example, that gelatin improves gut function just as bone broth did.^[1]

Fortunately, many of the benefits that are attributable to collagen, can also be conferred upon gelatin.

The reason is that there's a only small difference between gelatin and collagen because collagen is more refined - and thus more "pure" or isolated form of gelatin. What's true of collagen, must therefore also be true for gelatin.

The difference between gelatin and collagen, is that many people are better able to tolerate collagen.

Depending on your gut health, gelatin is generally harder to digest than collagen.

The upside of gelatin, however, is that it's cheaper than collagen. Because of its affordability - and because I easily digest gelatin - I'm mostly opting for grass-fed gelatin nowadays.

One benefit modern collagen products, however, is that they can be very specifically sourced.

Remember that bone broth, gelatin, and collagen can be sourced from different parts of the animal.

There are different collagen types on the market today. Some types of collagen are better for having joint benefits, while other types of collagen yield more skin benefits. More on that later.

(Advanced explanation: Depending sources distinguish between four and 28 different collagen types^[91]. Consider the five most common ones:

Type I; mostly found in the skin, tendons, ligaments, and bones.^[90]Supplementing with this collagen form reduces joint pain.^[112] Best sources: beef and fish.
Type II; is mainly found in cartilage and joints, as well as the eye.^[89]Type II collagen, moreover, has been proven to keep your joints and cartilage healthy.^{[96; 97; 98; 99; 105]} This effect is very specific for treating osteoarthritis and rheumatoid arthritis. These benefits entail that you will have less joint stiffness, less pain, and perhaps even reduce swelling levels. Chicken bones are especially rich in type II collagen.^{[116; 117; 118]}
Type III; located in internal organs, skin, and around bone.^{[92; 93]}Found mostly in beef
Type IV; primarily exists in the skin and gut, the eye lens, and around your cells.^{[94; 95]} This collagen type may specifically reduce gut problems.^[10] Examples of gut issues are inflammatory bowel disease and a leaky gut. Type IV collagen is also beneficial for skin healing.^[114]
Type V; supports types I an III; spread throughout the body.^{[88; 119; 120]}

Type I collagen is the most abundant in the human body. You can supplement with different types of collagen - all which seem to have different effects - although more research is needed).

So, what specific benefits does collagen have?

The use of collagen has been scientifically validated for improving skin structure and beauty.^{[64; 65; 66; 67; 68; 69; 70; 71; 72; 73; 100; 101]}

Collagen can also improve your hair quality, increasing hair growth and making your hair less thin.^{[103; 104]} The same is true for nails: brittle nails are reduced, and nail growth is stimulated.

Collagen is thus an excellent overall beauty product - improving your skin, hair, and nail quality.

The best way to use collagen for beauty purposes is to ingest collagen.

Again: do not rely on putting collagen on your skin, if you want optimal results. Collagen is poorly absorbed through your skin. Instead, ingest your collagen.

Does collagen have other benefits besides beauty?

Yes!

Collagen benefits for your bones - specifically increasing bone density, and combating osteoporosis ^{[106; 107; 110; 115].} The food also slows the decline in muscle mass loss when you age.^[109]

Keep in mind, however, that you'll need the right nutrients in your diet to optimally use collagen.

Adequate amounts of vitamin C are necessary to create collagen.^[125]

An overall diet where you consume high-quality shellfish, fatty fish, red and wild meat, healthy fats (e.g. butter; coconut oil), vegetables and fruits (in season) should give you the means to optimally use collagen.

Now that you've learned everything you need to know about the benefits of these foods, let's look at how you can use them in your diet.

How To Use Bone Broth, Gelatin, And Collagen

In this section, I'll explain how you can use bone broth, gelatin, and collagen. I'll provide some easy to use recipes so that you can integrate these very essential proteins into your life.

I'm already warning you, however: I'm a terrible cook.

Continue reading to find out why...

If you absolutely do not want to consume bone broth, gelatin, or collagen, then there are some alternatives. Certain meat cuts, such as oxtail, bone marrow, or chicken skins, are higher in the amino acids we're aiming for:

Chicken skin--not a perfect replacement.

Nevertheless, foods like chicken skin are not processed. Collagen, or bone broth, are processed, and therefore have much higher absorption rates.

Simply put, bone broth, gelatin, and collagen work better because they have been "broken down". Being broken down, they are easily digestible.

How to use bone broth, gelatin, and collagen?

Well, for the best results, simply consume one of these products every day.

If you have any gut issues, remember that bone broth is probably your best option. In that instance, begin consuming one cup of bone broth each day. Work your way up to two or three cups a day, if you tolerate bone broth well.

There are no hard guidelines to bone broth consumption - you have to experiment.

In general, I would aim to let 20-25% of the protein you ingest on a daily basis come from the bone broth, gelatin, and collagen food group.

To keep my recommendation very simple, let's assume that you're getting most of your protein from eggs, fish, shellfish, and red meat.

In that case, aim to include 1 cup of bone broth, or 1 tablespoon of gelatin or collagen, for every 6 ounces of eggs, fish, shellfish or red meat you consume.

It's that simple...

Let's now take a look at how you can make your own inexpensive (but world-class quality) bone broth.

Make Your Own Bone Broth

You don't have to be a chef to make your own bone broth.

Making your own bone broth just slightly more difficult than frying an egg.

Even I can do it. And I'm a terrible cook.

You should thus be able to make bone broth as well. To make bone broth, go through these ten steps:

Get a stainless steel pot, slow cooker, or pressure cooker.
Put the bones into the container, with water (preferably spring water). Make sure the water fully covers the bones.
Add vinegar to the water (which helps break up the bones). Wait one hour.
Boil the mixture of bones and water.
After the water cooks, lower the heat, and simmer for 2-48 hours. Simmering is the key here. If you cook the bones for long, your broth will be ruined...
Add water - if needed - to keep covering the bones.
When the simmer period is over, allow the bone broth to cool down.
Stain the broth, into a container.
Re-use the bones with the next batch. Bones can be used for 2-3 batches of broth.
Serve!

An optional step is to roast your bones in the oven before starting with step one on 230 degrees Celsius (450F). Roasting the bones for 20-30 minutes will make your bones more flavorful. This step is especially useful in the case of beef bones.

You might be asking: "why let the broth simmer this long?"

Well, there have been studies investigating a shorter versus longer extraction process.

A longer cooking time will make sure that you extract more nutrients, such as gelatin and glucosamine from your broth^{[9; 154]}. There are some guidelines for different animal bones have to simmer:

Beef bones: up to 48 hours
Chicken bones: up to 24 hours
Fish bones: up to 2 hours.

If possible, opt for bones that come from animals that are as young as possible. What's true of you and me, is true of animals as well--the younger you are, the more "gelatinous" proteins our bodies contain.

sockeye salmon swimming
Sockeye salmon - not only perfect for
nutrition, but their bones produce
the finest broth in the world.

You can guess my favorite option: fish broth. That broth is quick and easy.

Instead of just using the spine and fins of the fish, I often use fish heads as well. By adding the fish heads, you'll extract lots of healthy (omega 3) fatty acids into your broth as well.

When making fish broth, I usually combine all the bones in their body to make broth, while removing their gills.

The fish I buy, already has their guts and liver removed.

(To see how to prepare an entire fish for bone broth, click this link. Once you've removed the meat, the spine, fins, and head should be the only leftovers)

But let's say you're choosing beef or chicken. With these animals, there are two basic types of bones:

Bones coming from the joints. Examples are chicken feet, wings, or tights, or cow knuckles, feet, joints. You can even use cow ears! These bones contain a lot of gelatin.
Bones that have meat attached to them. In beef, they can be ribs, oxtail, shank, or marrow. In chicken, you can include the full skeleton. These bones are less prone to "gel", because they contain less gelatin. If there's meat on the bones, you can leave the meat attached during the simmering process. The meat adds flavor.

Of course, you can use lamb, fowl, or pig bones as well. These animals contains the same basic types of bones.

Combining the two types of bones will give the best effects. If you do not include a lot of bones from joints, your bone broth might not gel.

Gelling mans that the bone broth becomes a gelatinous "pudding" like substance. Without gelling, your broth will remain watery.

What to do when you have completed a large batch of broth?

Well, of course, first drink a cup. You can then refrigerate or freeze the remaining broth. In the refrigerator, broth should stay fresh a couple of days.

When you remove broth from your fridge after a couple of days, make sure to let the broth cook for a minute or two. Cooking the broth - that remained in your fridge - makes sure that any bacteria or pathogens are killed.

Then serve.

Instead of just using bones, you may add vegetables to your broth:

bones with vegetables

What type of vegetables you add, depend a bit on the animal that you're using.

When I was doing my fish broths - from skrei or wild cod - I often used onions, carrots, garlic, and celery. These vegetables are really a "classical" combination.

That combination is great to add to beef broth too.

Make sure you do not buy bone broth in your supermarket. Most store-bought bone broth is of sub-par quality. For example, store-bought broth often contains harmful additives.

However, there are three other reasons to make your own bone broth:

First of all, making your own bone broth is very cheap, if you get bones at the butcher.
Secondly, you can make large quantities of bone broth in just one sitting - a few liters of broth can last you for weeks. There's no excuse not to include broth into your diet, as you can often get bones for free.
Thirdly, making your own broth will lower your overall food costs The more broth you thus consume, the less you'll need other more expensive protein sources (e.g. beef; fish).

By the way, grab my 10 free tips on creating bone broth below:

Next, let me give you a few basic recipes for bone broth, gelatin, and collagen.

(Don't say I didn't warn you: my recipe section is underwhelming!)

First, gelatin...

1) Additive-Free Gelatin Gummy Bear Recipe

Lightly heat orange juice in a pan, and stir a few tablespoons of gelatin into the orange juice. When the gelatin has dissolved, pour the mixture into a mold.

Store the molds in the freezer for some time. Enjoy!

2) Beef Ribs With Onions And Bone Broth

Allow 2 pounds of beef ribs to assume room temperature:

Cut the beef into 1,5 inch cubes. Combine the beef with coriander, ginger, pepper, clove, paprika, nutmeg, and high-quality salt:

Heat coconut oil in a pan, and wait until the coconut oil becomes very hot. Then, brown the beef in the pan, until all sides of the beef cubes are seared:

Add beef bone broth, and 2 pounds of quartered onions.

Next, simmer for two hours. Done:

Collagen Coffee:

Is coffee too stimulating for you? Simply add one or two tablespoons of collagen to your coffee, to reduce the stimulatory effect.

The collagen will make sure the coffee is digested more slowly, so that you do not end up with that "jittery" feeling.

Yes, I admit:

This part of the ultimate guide is not so ultimate.

Sometimes you can't have it all in life. Fortunately, there are great other sources that will aid your imagination for creating recipes:

These options should give you much more leeway.

High-Quality Bone Broth, Gelatin, And Collagen Products

Let's say you really can't make your own bone broth. For example, you might be working 70-80 hours a week. In that case, this section is for you. Here, I'll review several bone broth, gelatin, and collagen products.

Gone are the days in 2010, when there were a few bone broth, gelatin and collagen offerings. There are now hundreds of offerings on the market. For that reason, this review section was included - saving you the time to go through hundreds of products.

I've rated bone broth, gelatin, and collagen products.

Regarding each food, I've distinguished between a first-rate product, and a best "bang for your buck" products. Phrased differently, the first is a premium product, and the second is an economy product.

What criteria did I use?

For me, these products should accord to the following criteria:

Organic--or have minimized pesticide use.
be as fresh as possible, in the case of bone broth.
Sourced from grass-fed or pasture raised animals. So, beef should be 100% grass-fed - chicken should be 100% pasture raised. A lot of companies call their products "grass-fed", when the animal only eats grass during part of their lives. That's why I opt for 100% grass-fed products. In the case of fish, moreover, the product should be sourced from a low-toxin. Fish should also not be farmed.
Be bio-available. For example, collagen should be hydrolyzed.
Additional ingredients should be minimized - and if possible, absent.
Animals should not be fed genetically modified organisms. So, the product should be non-GMO.
Antibiotics and hormone use should be minimized. Antibiotics only to be applied when animals are sick.
No preservatives, gluten, soy, dairy, nuts, wheat, peanuts, or any other additives. While I'm not against dairy, I know dairy is not for everyone. The product recommendation should be applicable for everyone, so dairy is out.
The container should be plastic-free, and especially BPA-free. BPA is a toxin found in many plastics.

I've applied these nine criteria to individual products on the basis of two information sources:

First, I've applied the criteria to the actual product descriptions. Secondly, I've included companies' answers to customers' questions. Sometimes these answers provided new important information.

My methodology is not perfect, however.

I made some assumptions.

For example, my methodology does not take into account the fact that product manufacturers could be lying about their production processes. Moreover, I did not lab test any products included in the review.

Nevertheless, the final outcomes were surprising.

Organic products were not always available. In addition, some very expensive products barely fared better than their inexpensive counterparts. Many companies stated that their products were grass fed, but very few companies offered 100% grass fed products.

In the category of collagen, moreover, multiple companies included more exotic types of collagen, such as type IV or X. But companies never disclosed how much of each specific collagen type was included.

The actual type IV or X makeup of the product might be as low a 1% of their weight.

I therefore decided not include any of the more expensive type IV or X products in my suggestions.

So, here's the outcome:

Best Bone Broth Product:

Kettle & Fire Bone Broth (discount code ALEXFERGUS saves you money)

Upside: endless variations of bone broth, with different types of beef bones, chicken bones, etcetera, also in combination with different additives such as turmeric, ginger, to make the product tasteful forever.

The Kettle & Fire also accords to organic principles because no antibiotics or hormones are used on the animals. Any other plant foods are also 100% organic.

Discount code ALEXFERGUS saves you money at Kettle & Fire

Best Gelatin And Best "Back For Your Buck" Gelatin Product:

Aspen Naturals Grass Fed Beef Gelatin Powder
(1,5 pounds)

Animal source: beef (type I and III collagen).

Upside: Affordable at $15,25 per pound. 100% grass-fed statement on the package. No additives.

Downside: Non-organic. Plastic container.

(Note: I could not find any high quality organic gelatin products, that function as the best gelatin product).

Best Collagen Product:

Antler Farms Collagen Protein
(1 pound)

Animal source: beef (type I and III collagen).

Upside: the only collagen product which explicitly advertised no chemicals or pesticides use. 100% grass fed.

Downside: Plastic container. High price at $39.99 per pound.

Bang For Your Buck" Collagen Product:

Perfotek Collagen Peptides
(1 pound)

Animal source: beef (type I and III collagen).

Upsides: No fillers. Non-GMO. Very affordable price of $18,99 per pound.

Downside: not organic. Not explicitly 100% grass fed. Plastic container.

You might be asking: "Bart, do I have to buy bone broth, gelatin, or collagen on the internet?

No.

If possible, you should not even want to buy these foods on the internet.

Getting healthy bones from your butcher is always preferred.

Lastly, how do I personally get these foods?

First, I've got a great butcher here in the Netherlands, who sells bone broth in glass containers for a very affordable price.

Secondly, there's a great inexpensive gelatin offering here in the Netherlands. The gelatin is sourced from 100% grass fed cows (but not organic). My advantage is that I don't necessarily need collagen, as I do not have gut issues. I'm thus not willing to pay more for collagen, when a more affordable gelatin product does the job for me.

That's it. Those are the two options I use.

So, look around. The best bone broth, gelatin, or collagen options might be sourced from the area you live in.

Conclusion: You Need Either Bone Broth, Gelatin, Or Collagen

Why should you consume bone broth, gelatin, and collagen?

First of all, you should consume products from this food group because they are great for your health.

Secondly, consuming the entire animal is great for the environment. You'll even save money on other more expensive proteins, such as red meat and fish.

Bone broth, gelatin, and collagen have all-round health benefits. The benefits range from improving your skin, to healing your gut, helping you lose fat, and increasing your energy levels.

Don't miss out on this food group. Include them in your diet.

I don't want to go as far as saying that these foods will change your life. What I will say, is that these foods are another great tool to get you close to optimal health.

Learn to make your own bone broth.

Update On Bone Broth

I no longer think bone broth is benign although it has great health qualities for many. By consuming bone broth you're ingesting tons of immunologically-sensitive substances, simply because you're breaking down bones and consuming those.

Some people can have an immunological response after eating bone broth that is relatively quick to dissipate. If you have such a reaction you'll frequently learn within a short period of time, of days, so it's not the most dangerous food intolerance to have.

If you do respond negatively to bone broth, build your health up first, and only introduce this food later on. Building your health, of course, is a complex issue that does not have a quick solution, but, many of of the suggestions on this blog will help you in that journey.

Found This Interesting? Then You Might Like:

This is a post by Bart Wolbers. Bart finished degrees in Physical Therapy (B), Philosophy (BA and MA), Philosophy of Science and Technology (MS - Cum Laude), and Clinical Health Science (MS), and is currently a health consultant at Alexfergus.com.

Show References

[1] Frasca G, Cardile V, Puglia C, Bonina C, Bonina F. Gelatin tannate reduces the proinflammatory effects of lipopolysaccharide in human intestinal epithelial cells. Clin Exp Gastroenterol. 2012;5:61-7. doi: 10.2147/CEG.S28792. Epub 2012 May 8.

[2] NIDKK. Opportunities & Challenges in Digestive Diseases Research: Recommendations of the National Commission on Digestive Diseases. https://www.niddk.nih.gov/about-niddk/strategic-plans-reports/Pages/opportunities-challenges-digestive-diseases-research-recommendations-national-commission-digestive-disease.aspxt

[3] Valenta R, Hochwallner H, Linhart B, Pahr S. Food allergies: the basics. Gastroenterology. 2015 May;148(6):1120-31.e4. doi: 10.1053/j.gastro.2015.02.006. Epub 2015 Feb 11.

[4] The Prevalence of Functional Gastrointestinal Disorders in the Chinese Air Force Population

[5] Canavan C. West J. Card T. Clin Epidemiol. 2014; 6: 71–80. The epidemiology of irritable bowel syndrome

[6] Zhang YJ, Li S, Gan RY, Zhou T, Xu DP, Li HB. Impacts of gut bacteria on human health and diseases. Int J Mol Sci. 2015 Apr 2;16(4):7493-519. doi: 10.3390/ijms16047493.

[7] Rennard BO, Ertl RF, Gossman GL, Robbins RA, Rennard SI. Chicken soup inhibits neutrophil chemotaxis in vitro. Chest. 2000 Oct;118(4):1150-7.

[8] Krajmalnik-Brown R, Ilhan ZE, Kang DW, DiBaise JK. Effects of gut microbes on nutrient absorption and energy regulation. Nutr Clin Pract. 2012 Apr;27(2):201-14. doi: 10.1177/0884533611436116. Epub 2012 Feb 24.

[9] Hsu DJ, Lee CW, Tsai WC, Chien YC. Essential and toxic metals in animal bone broths. Food Nutr Res. 2017 Jul 18;61(1):1347478. doi: 10.1080/16546628.2017.1347478. eCollection 2017.

[10] Koutroubakis IE, Petinaki E, Dimoulios P, Vardas E, Roussomoustakaki M, Maniatis AN, Kouroumalis EA. Serum laminin and collagen IV in inflammatory bowel disease. J Clin Pathol. 2003 Nov;56(11):817-20.

[11] Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. doi: 10.1159/000351376. Epub 2013 Aug 14.

[12] Ham DJ, Murphy KT, Chee A, Lynch GS, Koopman R. Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia. Clin Nutr. 2014 Jun;33(3):448-58. doi: 10.1016/j.clnu.2013.06.013. Epub 2013 Jun 26.

[13] Kim MH, Kim HM, Jeong HJ. strogen-like osteoprotective effects of glycine in in vitro and in vivo models of menopause. Amino Acids. 2016 Mar;48(3):791-800. doi: 10.1007/s00726-015-2127-6. Epub 2015 Nov 12.

[14] Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, Sanchez-Barrera R, Wacher NH, Carvajal-Sandoval G, Kumate J. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest. 2008 Aug;31(8):694-9.

[15] Hasegawa S, Ichiyama T, Sonaka I, Ohsaki A, Okada S, Wakiguchi H, Kudo K, Kittaka S, Hara M, Furukawa S. Cysteine, histidine and glycine exhibit anti-inflammatory effects in human coronary arterial endothelial cells. Clin Exp Immunol. 2012 Feb;167(2):269-74. doi: 10.1111/j.1365-2249.2011.04519.x.

[16] Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care. 2003 Mar;6(2):229-40.

[17]. Xu FL, You HB, Li XH, Chen XF, Liu ZJ, Gong JP. Glycine attenuates endotoxin-induced liver injury by downregulating TLR4 signaling in Kupffer cells. Am J Surg. 2008 Jul;196(1):139-48. doi: 10.1016/j.amjsurg.2007.09.045

[18] Bergheim I, Weber S, Vos M, Krämer S, Volynets V, Kaserouni S, McClain CJ, Bischoff SC.. Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin. J Hepatol. 2008 Jun;48(6):983-92. doi: 10.1016/j.jhep.2008.01.035. Epub 2008 Mar 14.

[19] Wheeler MD, Ikejema K, Enomoto N, Stacklewitz RF, Seabra V, Zhong Z, Yin M, Schemmer P, Rose ML, Rusyn I, Bradford B, Thurman RG. Glycine: a new anti-inflammatory immunonutrient. Cell Mol Life Sci. 1999 Nov 30;56(9-10):843-56.

[20] Cruz M, Maldonado-Bernal C, Mondragón-Gonzalez R, Sanchez-Barrera R, Wacher NH, Carvajal-Sandoval G, Kumate J. Glycine treatment decreases proinflammatory cytokines and increases interferon-gamma in patients with type 2 diabetes. J Endocrinol Invest. 2008 Aug;31(8):694-9.

[21] Ikejima K, Iimuro Y, Forman DT, Thurman RG. A diet containing glycine improves survival in endotoxin shock in the rat. Am J Physiol. 1996 Jul;271(1 Pt 1):G97-103.

[22] Díaz-Flores M, Cruz M, Duran-Reyes G, Munguia-Miranda C, Loza-Rodríguez H, Pulido-Casas E, Torres-Ramírez N, Gaja-Rodriguez O, Kumate J, Baiza-Gutman LA, Hernández-Saavedra D. Oral supplementation with glycine reduces oxidative stress in patients with metabolic syndrome, improving their systolic blood pressure. Can J Physiol Pharmacol. 2013 Oct;91(10):855-60. doi: 10.1139/cjpp-2012-0341. Epub 2013 Jun 17.

[23] Sekhar RV, McKay SV, Patel SG, Guthikonda AP, Reddy VT, Balasubramanyam A, Jahoor F. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care. 2011 Jan;34(1):162-7. doi: 10.2337/dc10-1006. Epub 2010 Oct 7.

[24] Sekhar RV, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F. Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53. doi: 10.3945/ajcn.110.003483. Epub 2011 Jul 27.

[25] Garcia-Macedo R, Sanchez-Muñoz F, Almanza-Perez JC, Duran-Reyes G, Alarcon-Aguilar F, Cruz M. Glycine increases mRNA adiponectin and diminishes pro-inflammatory adipokines expression in 3T3-L1 cells. Eur J Pharmacol. 2008 Jun 10;587(1-3):317-21. doi: 10.1016/j.ejphar.2008.03.051. Epub 2008 Apr 8.

[26] Wheeler MD, Thurman RG. Production of superoxide and TNF-alpha from alveolar macrophages is blunted by glycine. Am J Physiol. 1999 Nov;277(5 Pt 1):L952-9.

[27] El Hafidi M, Pérez I, Zamora J, Soto V, Carvajal-Sandoval G, Baños G. Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol Regul Integr Comp Physiol. 2004 Dec;287(6):R1387-93. Epub 2004 Aug 26.

[28] Wheeler MD, Rose ML, Yamashima S, Enomoto N, Seabra V, Madren J, Thurman RG. Dietary glycine blunts lung inflammatory cell influx following acute endotoxin. Am J Physiol Lung Cell Mol Physiol. 2000 Aug;279(2):L390-8.

[29] Senthilkumar R, Viswanathan P, Nalini N. Glycine modulates hepatic lipid accumulation in alcohol-induced liver injury. Pol J Pharmacol. 2003 Jul-Aug;55(4):603-11.

[30] Barakat HA, Hamza AH. Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats. Eur Rev Med Pharmacol Sci. 2012 Jun;16(6):728-36.

[31] Ham DJ, Murphy KT, Chee A, Lynch GS, Koopman R. Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia. Clin Nutr. 2014 Jun;33(3):448-58. doi: 10.1016/j.clnu.2013.06.013. Epub 2013 Jun 26.

[32] Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012 Apr 18;3:61. doi: 10.3389/fneur.2012.00061. eCollection 2012.

[33] Ding Y, Svingen GF, Pedersen ER, Gregory JF, Ueland PM, Tell GS, Nygård OK. Plasma Glycine and Risk of Acute Myocardial Infarction in Patients With Suspected Stable Angina Pectoris. J Am Heart Assoc. 2015 Dec 31;5(1). pii: e002621. doi: 10.1161/JAHA.115.002621.

[34] McCarty MF, DiNicolantonio JJ. The cardiometabolic benefits of glycine: Is glycine an 'antidote' to dietary fructose? Open Heart. 2014 May 28;1(1):e000103. doi: 10.1136/openhrt-2014-000103. eCollection 2014.

[35] González-Ortiz M, Medina-Santillán R, Martínez-Abundis E, von Drateln CR. Effect of glycine on insulin secretion and action in healthy first-degree relatives of type 2 diabetes mellitus patients. Horm Metab Res. 2001 Jun;33(6):358-60.

[36] Gannon MC, Nuttall JA, Nuttall FQ. The metabolic response to ingested glycine. Am J Clin Nutr. 2002 Dec;76(6):1302-7.

[37] Fiehn O, Garvey WT, Newman JW, Lok KH, Hoppel CL, Adams SH. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS One. 2010 Dec 10;5(12):e15234. doi: 10.1371/journal.pone.0015234.

[38] Nguyen D, Hsu JW, Jahoor F, Sekhar RV. Effect of increasing glutathione with cysteine and glycine supplementation on mitochondrial fuel oxidation, insulin sensitivity, and body composition in older HIV-infected patients. J Clin Endocrinol Metab. 2014 Jan;99(1):169-77. doi: 10.1210/jc.2013-2376. Epub 2013 Dec 20.

[39] Ruiz-Meana M, Pina P, Garcia-Dorado D, Rodríguez-Sinovas A, Barba I, Miró-Casas E, Mirabet M, Soler-Soler J. Glycine protects cardiomyocytes against lethal reoxygenation injury by inhibiting mitochondrial permeability transition. J Physiol. 2004 Aug 1;558(Pt 3):873-82. Epub 2004 Jun 24.

[40] Vieira CP, Guerra Fda R, de Oliveira LP, Almeida MS, Marcondes MC, Pimentell ER. Green tea and glycine aid in the recovery of tendinitis of the Achilles tendon of rats. Connect Tissue Res. 2015 Feb;56(1):50-8. doi: 10.3109/03008207.2014.983270. Epub 2014 Nov 21.

[41] Marsh DC, Vreugdenhil PK, Mack VE, Belzer FO, Southard JH. Glycine protects hepatocytes from injury caused by anoxia, cold ischemia and mitochondrial inhibitors, but not injury caused by calcium ionophores or oxidative stress. Hepatology. 1993 Jan;17(1):91-8.

[42] Yang S, Koo DJ, Chaudry IH, Wang P. Glycine attenuates hepatocellular depression during early sepsis and reduces sepsis-induced mortality. Crit Care Med. 2001 Jun;29(6):1201-6.

[43] Chen CY, Wang BT, Wu ZC, Yu WT, Lin PJ, Tsai WL, Shiesh SC. Glycine ameliorates liver injury and vitamin D deficiency induced by bile duct ligation. Clin Chim Acta. 2013 May;420:150-4. doi: 10.1016/j.cca.2012.10.016. Epub 2012 Oct 24.

[44] Akao T1, Kobashi K. Inhibitory effect of glycine on ethanol absorption from gastrointestinal tract. Biol Pharm Bull. 1995 Dec;18(12):1653-6.

[45]. Blum K, Wallace JE, Friedman RN. Reduction of acute alcoholic intoxication by alpha amino acids: glycine and serine. Life Sci. 1974 Feb 1;14(3):557-65

[46] Das SK, Harris RS. Effect of dietary supplementation of glycine on caries development and lipids in rat molars. J Dent Res. 1975 Sep-Oct;54(5):987-92.

[47] Meléndez-Hevia E, De Paz-Lugo P, Cornish-Bowden A, Cárdenas ML. A weak link in metabolism: the metabolic capacity for glycine biosynthesis does not satisfy the need for collagen synthesis. J Biosci. 2009 Dec;34(6):853-72.

[48] Gusev E, Skvortsova VI, Dambinova SA, Raevskiy KS, Alekseev AA, Bashkatova VG, Kovalenko AV, Kudrin VS, Yakovleva EV. Neuroprotective effects of glycine for therapy of acute ischaemic stroke. Cerebrovasc Dis. 2000 Jan-Feb;10(1):49-60.

[49] Altamura C, Maes M, Dai J, Meltzer HY. Plasma concentrations of excitatory amino acids, serine, glycine, taurine and histidine in major depression. Eur Neuropsychopharmacol. 1995;5 Suppl:71-5.

[50] Maes M, Verkerk R, Vandoolaeghe E, Lin A, Scharpé S. Serum levels of excitatory amino acids, serine, glycine, histidine, threonine, taurine, alanine and arginine in treatment-resistant depression: modulation by treatment with antidepressants and prediction of clinical responsivity. Acta Psychiatr Scand. 1998 Apr;97(4):302-8.

[51] Greenberg WM, Benedict MM, Doerfer J, Perrin M, Panek L, Cleveland WL, Javitt DC. Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults. J Psychiatr Res. 2009 Mar;43(6):664-70. doi: 10.1016/j.jpsychires.2008.10.007. Epub 2008 Nov 30.

[52] Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):165-71.

[53] Javitt DC, Zylberman I, Zukin SR, Heresco-Levy U, Lindenmayer JP. Amelioration of negative symptoms in schizophrenia by glycine. Am J Psychiatry. 1994 Aug;151(8):1234-6.

[54] Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Horowitz A, Kelly D. Double-blind, placebo-controlled, crossover trial of glycine adjuvant therapy for treatment-resistant schizophrenia. Br J Psychiatry. 1996 Nov;169(5):610-7.

[55] Heresco-Levy U, Ermilov M, Lichtenberg P, Bar G, Javitt DC. High-dose glycine added to olanzapine and risperidone for the treatment of schizophrenia. Biol Psychiatry. 2004 Jan 15;55(2):165-71.

[56]. Heresco-Levy U, Javitt DC, Ermilov M, Mordel C, Silipo G, Lichtenstein M. Efficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 1999 Jan;56(1):29-36

[57] Farber NB, Newcomer JW, Olney JW. Glycine agonists: what can they teach us about schizophrenia? Arch Gen Psychiatry. 1999 Jan;56(1):13-7.

[58] Cleveland WL, DeLaPaz RL, Fawwaz RA, Challop RS. High-dose glycine treatment of refractory obsessive-compulsive disorder and body dysmorphic disorder in a 5-year period. Neural Plast. 2009;2009:768398. doi: 10.1155/2009/768398. Epub 2010 Feb 18

[59] Bannai M1, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-8. Epub 2012 Jan 27.

[60] Kawai N, Sakai N, Okuro M, Karakawa S, Tsuneyoshi Y, Kawasaki N, Takeda T, Bannai M, Nishino S. The sleep-promoting and hypothermic effects of glycine are mediated by NMDA receptors in the suprachiasmatic nucleus. Neuropsychopharmacology. 2015 May;40(6):1405-16. doi: 10.1038/npp.2014.326. Epub 2014 Dec 23.

[61] Razak MA, Begum PS, Viswanath B, Rajagopal S. Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1.

[62] Petrat F, Boengler K, Schulz R, de Groot H. Glycine, a simple physiological compound protecting by yet puzzling mechanism(s) against ischaemia-reperfusion injury: current knowledge. Br J Pharmacol. 2012 Apr;165(7):2059-72. doi: 10.1111/j.1476-5381.2011.01711.x.

[63] Bannai M, Kawai N, Ono K, Nakahara K, Murakami N. The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers. Front Neurol. 2012 Apr 18;3:61. doi: 10.3389/fneur.2012.00061. eCollection 2012.

[64] Choi SY, Ko EJ, Lee YH, Kim BG, Shin HJ, Seo DB, Lee SJ, Kim BJ, Kim MN. Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. J Cosmet Laser Ther. 2014 Jun;16(3):132-7. doi: 10.3109/14764172.2013.854119. Epub 2013 Nov 18.

[65] Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. doi: 10.1159/000351376. Epub 2013 Aug 14.

[66] Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. doi: 10.1159/000355523. Epub 2013 Dec 24.

[67] Lee SK, Posthauer ME, Dorner B, Redovian V, Maloney MJ. Pressure ulcer healing with a concentrated, fortified, collagen protein hydrolysate supplement: a randomized controlled trial. Adv Skin Wound Care. 2006 Mar;19(2):92-6.

[68] Zhang Z, Wang J, Ding Y, Dai X, Li Y. Oral administration of marine collagen peptides from Chum Salmon skin enhances cutaneous wound healing and angiogenesis in rats. J Sci Food Agric. 2011 Sep;91(12):2173-9. doi: 10.1002/jsfa.4435. Epub 2011 May 10.

[69] Zhang Z1, Zhao M, Wang J, Ding Y, Dai X, Li Y. Oral administration of skin gelatin isolated from Chum salmon (Oncorhynchus keta) enhances wound healing in diabetic rats. Mar Drugs. 2011;9(5):696-711. doi: 10.3390/md9050696. Epub 2011 Apr 26.

[70] Asserin J, Lati E, Shioya T, Prawitt J. The effect of oral collagen peptide supplementation on skin moisture and the dermal collagen network: evidence from an ex vivo model and randomized, placebo-controlled clinical trials. J Cosmet Dermatol. 2015 Dec;14(4):291-301. doi: 10.1111/jocd.12174. Epub 2015 Sep 12.

[71] Song H, Zhang L, Luo Y, Zhang S, Li B. Effects of collagen peptides intake on skin ageing and platelet release in chronologically aged mice revealed by cytokine array analysis. J Cell Mol Med. 2018 Jan;22(1):277-288. doi: 10.1111/jcmm.13317. Epub 2017 Sep 18.

[72] De Luca C, Mikhal'chik EV, Suprun MV, Papacharalambous M, Truhanov AI, Korkina LG. Skin Antiageing and Systemic Redox Effects of Supplementation with Marine Collagen Peptides and Plant-Derived Antioxidants: A Single-Blind Case-Control Clinical Study. Oxid Med Cell Longev. 2016;2016:4389410. doi: 10.1155/2016/4389410. Epub 2016 Jan 19.

[73] Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8. doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 12.

[74] Tanaka M1, Koyama Y, Nomura Y. Effects of collagen peptide ingestion on UV-B-induced skin damage. Biosci Biotechnol Biochem. 2009 Apr 23;73(4):930-2. Epub 2009 Apr 7.

[75] Schaefer N, Tahara K, Schuchtrup S, Websky MV, Overhaus M, Schmidt J, Wirz S, Abu-Elmagd KM, Kalff JC, Hirner A, Türler A. Perioperative glycine treatment attenuates ischemia/reperfusion injury and ameliorates smooth muscle dysfunction in intestinal transplantation. Transplantation. 2008 May 15;85(9):1300-10. doi: 10.1097/TP.0b013e31816c576f.

[76] Ruth MR, Field CJ. The immune modifying effects of amino acids on gut-associated lymphoid tissue. J Anim Sci Biotechnol. 2013 Jul 30;4(1):27. doi: 10.1186/2049-1891-4-27.

[77] de Aguiar Picanço E, Lopes-Paulo F, Marques RG, Diestel CF, Caetano CE, de Souza MV, Moscoso GM, Pazos HM. L-arginine and glycine supplementation in the repair of the irradiated colonic wall of rats. Int J Colorectal Dis. 2011 May;26(5):561-8. doi: 10.1007/s00384-011-1154-3. Epub 2011 Feb 25.

[78] Müller P1, Dammann HG, Bergdolt H, Simon B. [The effect of glycine on the gastroduodenal tolerability of acetylsalicylic acid. An endoscopic, controlled double-blind study in healthy subjects]. Arzneimittelforschung. 1991 Aug;41(8):812-4.

[79] Chen Q, Chen O, Martins IM, Hou H, Zhao X. Blumberg JB, Li B. Collagen peptides ameliorate intestinal epithelial barrier dysfunction in immunostimulatory Caco-2 cell monolayers via enhancing tight junctions. Food Funct. 2017 Mar 22;8(3):1144-1151. doi: 10.1039/c6fo01347c.

[80] Barbul A1. Proline precursors to sustain Mammalian collagen synthesis. J Nutr. 2008 Oct;138(10):2021S-2024S.

[81] Jaksic T, Wagner DA, Young VR. Plasma proline kinetics and concentrations in young men in response to dietary proline deprivation. Am J Clin Nutr. 1990 Aug;52(2):307-12.

[82] Nusgens B, Lapiere CM. The relationship between proline and hydroxyproline urinary excretion in human as an index of collagen catabolism. Clin Chim Acta. 1973 Oct 12;48(2):203-11.

[83] Jackson AA, Badaloo AV, Forrester T, Hibbert JM, Persaud C. Urinary excretion of 5-oxoproline (pyroglutamic aciduria) as an index of glycine insufficiency in normal man. Br J Nutr. 1987 Sep;58(2):207-14.

[84] Shoulders MD, Raines RT. Collagen structure and stability. Annu Rev Biochem. 2009;78:929-58. doi: 10.1146/annurev.biochem.77.032207.120833.

[85] Heino J. The collagen family members as cell adhesion proteins. Bioessays. 2007 Oct;29(10):1001-10.

[86] Aziz J, Shezali H, Radzi Z, Yahya NA, Abu Kassim NH, Czernuszka J, Rahman MT. Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin. Skin Pharmacol Physiol. 2016;29(4):190-203. doi: 10.1159/000447017. Epub 2016 Jul 20.

[87] Schemmer P, Zhong Z, Galli U, Wheeler MD, Xiangli L, Bradford BU, Conzelmann LO, Forman D, Boyer J, Thurman RG. Glycine reduces platelet aggregation. Amino Acids. 2013 Mar;44(3):925-31. doi: 10.1007/s00726-012-1422-8. Epub 2012 Nov 8.

[88] Birk DE. Type V collagen: heterotypic type I/V collagen interactions in the regulation of fibril assembly. Micron. 2001 Apr;32(3):223-37.

[89] Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030.

[90] Dalgleish R. The human type I collagen mutation database. Nucleic Acids Res. 1997 Jan 1;25(1):181-7.

[91] Ricard-Blum S. The collagen family. Cold Spring Harb Perspect Biol. 2011 Jan 1;3(1):a004978. doi: 10.1101/cshperspect.a004978.

[92] Volk SW, Shah SR, Cohen AJ, Wang Y, Brisson BK, Vogel LK, Hankenson KD, Adams SL. Type III collagen regulates osteoblastogenesis and the quantity of trabecular bone. Calcif Tissue Int. 2014 Jun;94(6):621-31. doi: 10.1007/s00223-014-9843-x. Epub 2014 Mar 14.

[93] Liu X, Wu H, Byrne M, Krane S, Jaenisch R. Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1852-6.

[94]. Kühn K. Basement membrane (type IV) collagen. Matrix Biol. 1995 Feb;14(6):439-45

[95] Abreu-Velez AM, Howard MS. Collagen IV in Normal Skin and in Pathological Processes. N Am J Med Sci. 2012 Jan;4(1):1-8. doi: 10.4103/1947-2714.92892.

[96] Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24;261(5129):1727-30.

[97] Barnett ML, Kremer JM, St Clair EW, Clegg DO, Furst D, Weisman M, Fletcher MJ, Chasan-Taber S, Finger E, Morales A, Le CH, Trentham DE. Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial. Arthritis Rheum. 1998 Feb;41(2):290-7.

[98] Crowley DC, Lau FC, Sharma P, Evans M, Guthrie N, Bagchi M, Bagchi D, Dey DK, Raychaudhuri SP. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009 Oct 9;6(6):312-21.

[99] Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908X291967 . Epub 2008 Apr 15.

[100] Inoue N, Sugihara F, Wang X. Ingestion of bioactive collagen hydrolysates enhance facial skin moisture and elasticity and reduce facial ageing signs in a randomised double-blind placebo-controlled clinical study. J Sci Food Agric. 2016 Sep;96(12):4077-81. doi: 10.1002/jsfa.7606. Epub 2016 Feb 10.

[101] Clark KL, Sebastianelli W, Flechsenhar KR, Aukermann DF, Meza F, Millard RL, Deitch JR, Sherbondy PS, Albert A. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008 May;24(5):1485-96. doi: 10.1185/030079908X291967 . Epub 2008 Apr 15.

[102] Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017 Jun;42(6):588-595. doi: 10.1139/apnm-2016-0390. Epub 2017 Jan 24.

[103] Glynis A. A Double-blind, Placebo-controlled Study Evaluating the Efficacy of an Oral Supplement in Women with Self-perceived Thinning Hair. J Clin Aesthet Dermatol. 2012 Nov;5(11):28-34.

[104] Turowski A, Adelmann-Grill BC. Substantivity to hair and skin of l-labelled collagen hydrolysates under application simulating conditions. Int J Cosmet Sci. 1985 Apr;7(2):71-84. doi: 10.1111/j.1467-2494.1985.tb00398.x.

[105] Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32

[106] Nomura Y, Oohashi K, Watanabe M, Kasugai S. Increase in bone mineral density through oral administration of shark gelatin to ovariectomized rats. Nutrition. 2005 Nov-Dec;21(11-12):1120-6.

[107] Wu J, Fujioka M, Sugimoto K, Mu G, Ishimi Y. Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats. J Bone Miner Metab. 2004;22(6):547-53.

[108] Zhu CF1, Li GZ, Peng HB, Zhang F, Chen Y, Li Y. Therapeutic effects of marine collagen peptides on Chinese patients with type 2 diabetes mellitus and primary hypertension. Am J Med Sci. 2010 Nov;340(5):360-6. doi: 10.1097/MAJ.0b013e3181edfcf2.

[109] Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A. König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015 Oct 28;114(8):1237-45. doi: 10.1017/S0007114515002810. Epub 2015 Sep 10.

[110] König D, Oesser S, Scharla S, Zdzieblik D, Gollhofer A. Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients. 2018 Jan 16;10(1). pii: E97. doi: 10.3390/nu10010097.

[111] Hexsel D, Zague V, Schunck M, Siega C, Camozzato FO, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017 Dec;16(4):520-526. doi: 10.1111/jocd.12393. Epub 2017 Aug 8.

[112] Bruyère O, Zegels B, Leonori L, Rabenda V, Janssen A, Bourges C, Reginster JY. Effect of collagen hydrolysate in articular pain: a 6-month randomized, double-blind, placebo controlled study. Complement Ther Med. 2012 Jun;20(3):124-30. doi: 10.1016/j.ctim.2011.12.007. Epub 2012 Jan 20.

[113] Chen P, Cescon M, Bonaldo P. Lack of Collagen VI Promotes Wound-Induced Hair Growth. J Invest Dermatol. 2015 Oct;135(10):2358-2367. doi: 10.1038/jid.2015.187. Epub 2015 May 19.

[114] Kadler KE. Holmes DF. Trotter JA. Chapman JA. Collagen fibril formation. Biochem J. 1996 May 15; 316(Pt 1): 1–11.

[115] Shen G. The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage. Orthod Craniofac Res. 2005 Feb;8(1):11-7.

[116] Xu D, Shen W. Chicken collagen type II reduces articular cartilage destruction in a model of osteoarthritis in rats. West Indian Med J. 2007 Jun;56(3):202-7.

[117] Bagi CM, Berryman ER, Teo S, Lane NE. Oral administration of undenatured native chicken type II collagen (UC-II) diminished deterioration of articular cartilage in a rat model of osteoarthritis (OA). Osteoarthritis Cartilage. 2017 Dec;25(12):2080-2090. doi: 10.1016/j.joca.2017.08.013. Epub 2017 Sep 6.

[118] Bagchi D, Misner B, Bagchi M, Kothari SC, Downs BW, Fafard RD, Preuss HG. Effects of orally administered undenatured type II collagen against arthritic inflammatory diseases: a mechanistic exploration. nt J Clin Pharmacol Res. 2002;22(3-4):101-10.

[119] Mak KM, Png CY, Lee DJ. Type V Collagen in Health, Disease, and Fibrosis. Anat Rec (Hoboken). 2016 May;299(5):613-29. doi: 10.1002/ar.23330. Epub 2016 Mar 15.

[120] Wong M, Hendrix MJ, von der Mark K, Little C, Stern R. Collagen in the egg shell membranes of the hen. Dev Biol. 1984 Jul;104(1):28-36.

[121] Arias JL1, Fernandez MS, Dennis JE, Caplan AI. The fabrication and collagenous substructure of the eggshell membrane in the isthmus of the hen oviduct. Matrix. 1991 Nov;11(5):313-20.

[122] Pérez-Torres I, Zuniga-Munoz AM, Guarner-Lans V. Beneficial Effects of the Amino Acid Glycine. Mini Rev Med Chem. 2017;17(1):15-32.

[123] Szpak P. Fish bone chemistry and ultrastructure: implications for taphonomy and stable isotope analysis. Journal of Archaeological Science. 38, 2011, (12): 3358–3372. doi:10.1016/j.jas.2011.07.022.

[124] Boyera N, Galey I, Bernard BA. Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts. Int J Cosmet Sci. 1998 Jun;20(3):151-8. doi: 10.1046/j.1467-2494.1998.171747.x.

[125] Pullar JM, Carr AC, Vissers MCM. The Roles of Vitamin C in Skin Health. Nutrients. 2017 Aug 12;9(8). pii: E866. doi: 10.3390/nu9080866.

[126] Nakashima K, Yakabe Y, Ishida A, Katsumata M. Effects of orally administered glycine on myofibrillar proteolysis and expression of proteolytic-related genes of skeletal muscle in chicks. Amino Acids. 2008 Aug;35(2):451-6. Epub 2007 Jul 12.

[127] Männistö PT, Mattila J, Tuominen RK, Vesalainen S. Effects of some putative amino acid neurotransmitters on the stimulated TSH secretion in male rats. Horm Res. 1983;17(1):19-26.

[128] Ray Peat. Gelatin, Stress, Longevity. http://raypeat.com/articles/articles/gelatin.shtml

[129] Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002 Feb 8;277(6):4223-31. Epub 2001 Nov 9.

[130] Alpers DH. Is glutamine a unique fuel for small intestinal cells? Curr Opin Gastroenterol. 2000 Mar;16(2):155.

[131] Li Y1, Yu Z, Liu F, Tan L, Wu B, Li J. Oral glutamine ameliorates chemotherapy-induced changes of intestinal permeability and does not interfere with the antitumor effect of chemotherapy in patients with breast cancer: a prospective randomized trial. Tumori. 2006 Sep-Oct;92(5):396-401.

[132] Rennie MJ, MacLennan PA, Hundal HS, Weryk B, Smith K, Taylor PM, Egan C, Watt PW. Skeletal muscle glutamine transport, intramuscular glutamine concentration, and muscle-protein turnover. Metabolism. 1989 Aug;38(8 Suppl 1):47-51.

[133] Rao R, Samak G. Role of Glutamine in Protection of Intestinal Epithelial Tight Junctions. J Epithel Biol Pharmacol. 2012 Jan;5(Suppl 1-M7):47-54.

[134] Kim MH, Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci. 2017 May 12;18(5). pii: E1051. doi: 10.3390/ijms18051051.

[135] Wang B. Wu G. Zhou Z. Dai Z. Sun Y. Ji Y. Li W. Wang W. Liu C. Han F. Wu Z. Glutamine and intestinal barrier function. Amino Acids. 2015 Oct;47(10):2143-54. doi: 10.1007/s00726-014-1773-4. Epub 2014 Jun 26.

[136] Ziegler TR. Bazargan N, Leader LM, Martindale RG. Glutamine and the gastrointestinal tract. Curr Opin Clin Nutr Metab Care. 2000 Sep;3(5):355-62.

[137] Rosen HN, Salemme H, Zeind AJ, Moses AC, Shapiro A, Greenspan SL. Chicken soup revisited: calcium content of soup increases with duration of cooking. Calcif Tissue Int. 1994 Jun;54(6):486-8.

[138] Kongtharvonskul J, Anothaisintawee T, McEvoy M, Attia J, Woratanarat P, Thakkinstian A. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis. Eur J Med Res. 2015 Mar 13;20:24. doi: 10.1186/s40001-015-0115-7.

[139] Towheed TE, Maxwell L, Anastassiades TP, Shea B, Houpt J, Robinson V, Hochberg MC, Wells G. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD002946.

[140] Matsuno H, Nakamura H, Katayama K, Hayashi S, Kano S, Yudoh K, Kiso Y. Effects of an oral administration of glucosamine-chondroitin-quercetin glucoside on the synovial fluid properties in patients with osteoarthritis and rheumatoid arthritis. Biosci Biotechnol Biochem. 2009 Feb;73(2):288-92. Epub 2009 Feb 7.

[141] Provenza JR, Shinjo SK, Silva JM, Peron CR, Rocha FA. Combined glucosamine and chondroitin sulfate, once or three times daily, provides clinically relevant analgesia in knee osteoarthritis. Clin Rheumatol. 2015 Aug;34(8):1455-62. doi: 10.1007/s10067-014-2757-1. Epub 2014 Aug 3.

[142] Black C, Clar C, Henderson R, MacEachern C, McNamee P, Quayyum Z, Royle P, Thomas S. The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation. Health Technol Assess. 2009 Nov;13(52):1-148. doi: 10.3310/hta13520.

[143] Kantor ED, Lampe JW, Navarro SL, Song X, Milne GL, White E. Associations between glucosamine and chondroitin supplement use and biomarkers of systemic inflammation. J Altern Complement Med. 2014 Jun;20(6):479-85. doi: 10.1089/acm.2013.0323. Epub 2014 Apr 16.

[144] Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer M. Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil. 2011 Aug;92(8):1185-93. doi: 10.1016/j.apmr.2011.03.009.

[145] Yoshimura M1, Sakamoto K, Tsuruta A, Yamamoto T, Ishida K, Yamaguchi H, Nagaoka I. Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med. 2009 Oct;24(4):487-94.

[146] Momomura R, Naito K, Igarashi M, Watari T, Terakado A, Oike S, Sakamoto K, Nagaoka I, Kaneko K. Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Mol Med Rep. 2013 Mar;7(3):742-6. doi: 10.3892/mmr.2013.1289. Epub 2013 Jan 25.

[147] Bissett DL. Glucosamine: an ingredient with skin and other benefits. J Cosmet Dermatol. 2006 Dec;5(4):309-15.

[148] Schlessinger J, Green B, Edison BL, Murphy L, Sabherwal Y. A Firming Neck Cream Containing N-Acetyl Glucosamine Significantly Improves Signs of Aging on the Challenging Neck and Décolletage. J Drugs Dermatol. 2016 Jan;15(1):47-52.

[149] Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. Dermatoendocrinol. 2012 Jul 1;4(3):253-8. doi: 10.4161/derm.21923.

[150] Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs. 1994 Mar;47(3):536-66.

[151] Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. J Bone Joint Surg Am. 2004 Mar;86-A(3):538-45.

[152] Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. 2000 Dec;2(6):466-71.

[153] Kawada C, Yoshida T, Yoshida H, Matsuoka R, Sakamoto W, Odanaka W, Sato T, Yamasaki T, Kanemitsu T, Masuda Y, Urushibata O. Ingested hyaluronan moisturizes dry skin. Nutr J. 2014 Jul 11;13:70. doi: 10.1186/1475-2891-13-70.

[154] Monro JA, Leon R, Puri BK. The risk of lead contamination in bone broth diets. Med Hypotheses. 2013 Apr;80(4):389-90. doi: 10.1016/j.mehy.2012.12.026. Epub 2013 Jan 31.

[155] Fasano A. Leaky gut and autoimmune diseases. Clin Rev Allergy Immunol. 2012 Feb;42(1):71-8. doi: 10.1007/s12016-011-8291-x.

[156] Mu Q, Kirby J, Reilly CM, Luo XM. Leaky Gut As a Danger Signal for Autoimmune Diseases. Front Immunol. 2017 May 23;8:598. doi: 10.3389/fimmu.2017.00598. eCollection 2017.

[157] Wu HJ, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes. 2012 Jan-Feb;3(1):4-14. doi: 10.4161/gmic.19320. Epub 2012 Jan 1.

[158] Ho W, Spiegel BM. The relationship between obesity and functional gastrointestinal disorders: causation, association, or neither? Gastroenterol Hepatol (N Y). 2008 Aug;4(8):572-8.

[159] Harper JW, Zisman TL. Interaction of obesity and inflammatory bowel disease. World J Gastroenterol. 2016 Sep 21;22(35):7868-81. doi: 10.3748/wjg.v22.i35.7868.

[160] Clapp M, Aurora N, Herrera L, Bhatia M, Wilen E, Wakefield S. Gut microbiota's effect on mental health: The gut-brain axis. Clin Pract. 2017 Sep 15;7(4):987. doi: 10.4081/cp.2017.987. eCollection 2017 Sep 15.

[161] Requena T, Martínez-Cuesta MC , Peláez C. Diet and microbiota linked in health and disease. Food Funct. 2018 Feb 21;9(2):688-704. doi: 10.1039/c7fo01820g.

[162] Clemente JC, Ursell LK, Parfrey LW, Knight R. The impact of the gut microbiota on human health: an integrative view. Cell. 2012 Mar 16;148(6):1258-70. doi: 10.1016/j.cell.2012.01.035.

[163] Dinan TG, Cryan JF. The Microbiome-Gut-Brain Axis in Health and Disease. Gastroenterol Clin North Am. 2017 Mar;46(1):77-89. doi: 10.1016/j.gtc.2016.09.007. Epub 2017 Jan 4.

[164] Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006 Jun;168(6):1861-8.

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The Ultimate Bone Broth, Gelatin, and Collagen Protein Guide

The Ultimate Bone Broth, Gelatin, And Collagen Protein Guide

Table of Contents

Summary: Bone Broth, Gelatin, And Collagen

Introduction: Why You Need Bone Broth, Gelatin, Or Collagen

Differences Between Bone Broth, Gelatin, And Collagen

Amino Acids In Bone Broth, Gelatin, And Collagen

Shared Benefits Of Bone Broth, Gelatin, And Collagen

Specific Benefits Of Bone Broth, Gelatin, Or collagen

How To Use Bone Broth, Gelatin, And Collagen

Make Your Own Bone Broth

High-Quality Bone Broth, Gelatin, And Collagen Products

So, here's the outcome:

You might be asking: "Bart, do I have to buy bone broth, gelatin, or collagen on the internet?

Conclusion: You Need Either Bone Broth, Gelatin, Or Collagen

Update On Bone Broth

Other Questions:

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