Why Is Air Pollution A Problem? How Air Pollution Imperceptibly Degrades Your Health
Welcome to my series on air pollution and health. In this first part of this 3 or 4 installment series, I'll consider why the problems of air pollution are terribly underestimated and I'll show you how air pollution has affected human health throughout history.
Keep in mind that I've written a series about particulate matter recently as well. For instance, 1) I've defined what particulate matter is; 2) ten devastating health effects of particulate matter exposure; 3) the best air purifier for lowering particulate matter exposure, and; 4) seven additional strategies to lower your exposure 90%+.
This blog post series will be similar. This blog post series will treat many different air pollutants, not just particulate matter. Examples of air pollutants include Sulfur Dioxide (SO2), Nitrogen Dioxide (NO2), toxic mold, etcetera.
As almost always, moreover, I'll start by defining the problem. Let's find out why many people underappreciate and misunderstand why air pollution is a problem:
Introduction: Why The Health Effects Of Air Pollution Are Terribly Underestimated
Let start on a little detour - you understand what I'm getting at regarding air pollution very soon.
I'm going to talk about facing the reality of an obvious problem first.
And you know what?
Consciously acknowledging an elephant in the room can be deceptively difficult.
Examples:
- You may be working at an internet company that has losses quarter after quarter, and yet, everyone working there is acting like it's 1998 - having that cheerful attitude they had at the height of the internet stock bubble.
- A friend of yours, who has smoked for 30 years, has been coughing for a few weeks now. He tells you: "maybe it's the colder weather that's causing these lung problems?"
- Your colleague claims to be so busy that she doesn't have time to meet up. But you know that she's spending 6 hours a day on her smartphone and in front of a television.
- It's now 10 years since the world has experienced the last global recession. And yet, government projections, companies, and consumer sentiments all assume that the party will continue for several years (and up to a decade)...
I know...
Acknowledging an elephant in the room takes guts.
But let's face it:
You may not like what you see, but only by consciously acknowledging problems can you change anything.
Many people living in the city are confronted with such an elephant every day...
You may be too.
Which one?
Air pollution is like an elephant.
A huge pink elephant. Everyone just knows that elephant exists.
And yet, there's a strange phenomenon going on regarding air pollution: most people are unwilling to tackle the problem directly.
That's weird...
Let me tell you why - I'll give an analogy:
Most people know they should exercise, and for that reason they do. If I were to make a rough guesstimate, about 60% of people in my country (the Netherlands) exercise in one form or another.
Many people also know they should watch their diet, and for that reason, they do. To be more precise: most health-conscious people intentionally avoid eating at McDonald's or Burger King 6 times a week.
In the case of air pollution, however, a switch is triggered.
Let me explain:
Ask the fitness addict who spends 5 evenings a week in the gym and watches her diet meticulously what she does to lower her exposure to air pollution. Or go to a health store and ask the owner what products he's offering to counter air pollutants.
You'll be met with a blank stare...
So ask yourself this simple question:
How many health-conscious people do you know who as carefully watch their air pollution exposure as they care about their exercise or diet?
One percent?
Two percent?
My rough guesstimate is that two percent of health-conscious people watch their air pollution levels - at the maximum.
And yet, if you care about your health you should care about air pollution.
Let me tell you why:
8 million people die every single year because of the negative health effects of air pollution (on a worldwide basis).[1; 2; 3; 4]
Sure, most of these deaths occur in Asia, but even developed countries have air pollution levels that negatively affect your health no matter where you live.
It may sound counter-intuitive, but even in the developed world hundreds of thousands of people still die due to air pollution's effects.
And no, not every decade but every year...
Of course, there are many different causes of air pollution, such as aerosols from sprays, natural causes such as forest fires or volcanoes, indoor cooking that "kills" air quality, gases, and tiny particles emitted by car or airplanes, and industrial output...
I'll treat all these causes in a subsequent section...
The key is to realize that all these air pollutants place a tremendous burden on your health.
Think about it: 8 million, that's a lot of people dying each year because of the direct effects of air pollution...
The problem with grasping that "8 million" figure is that everyone doesn't necessarily die from air pollution - even when they're exposed.
Of course, I'm not arguing that more people should die. What I'm saying instead is that the statistics are short-sighted.
Why?
Let's return to the figure of 8 million "deaths" per year. A death occurs when someone dies while being able to live many more months or years.
Besides the 8 million yearly deaths, at least 100 times as many people's health is negatively affected.
Even if you don't die, air pollution thus still worsens your health.
Example:
If I die in 10 years due to an accident (hopefully not), and I've breathed polluted air for 42 years by then, air pollution has still negatively affected my health over that period.
It's also very likely that you, the reader who's living in a developed country is not going to die directly from air pollution.
And yet, your heart and lung health will be negatively affected by dirty air.
That's bad news...
Immediate perception does not always match reality.
The same is true for air pollution: the problem is worse than you think.
Let's explore why air pollution is so under-emphasized:
Air pollution is called "the invisible killer"...
Why?
The stuff you're breathing is like an imperceptible poison drip.
Just imagine that each day, your "loving" partner adds a little bit of arsenic to your meals. Arsenic is a poison and does not have any taste or odor, but you'll start feeling pretty bad once you ingest too much of the stuff.
Over time, even though your partner creates "wonderful" meals for you, incredible damage is being done.
Your health deteriorates imperceptibly and in time you'll start thinking that you're struck by fate.
Of course that conclusion is completely wrong, but still, if you do think you had "bad luck" you may assume that there's nothing you will do about that situation.
Then your helplessness starts...
The analogy here is that air pollution's health effects are also imperceptible. Due to that imperceptibility, most people are not consciously aware of the air they're breathing--unless, perhaps, they already have lung problems.
That's bad for you, as damage is being done even if you don't think there is.
I'll tell you...
Don't worry: I'm not preaching despair...
On the contrary:
By taking the problem air pollution head on you can decrease your risks for several health problems, such as lung problems, heart disease, and cancer.
To experience these benefits though, you do need to take action.
To be more precise: you need to take action...
Yes, you...
Don't wait for:
- the government to change laws so that less air pollution exists
- a genius comes up with a solution that filters the air perfectly once and for all
- your health to deteriorate because you're unwilling to face the problem directly
- being able to move to another location where less air pollution is present
And it's precisely air pollution's invisibility why so few health-conscious people take action in the first place...
Many people:
- just don't know what to do about air pollution. You may not know either...
- may have never become fully consciously aware of how bad the health effects of air pollution really are. (After reading this blog post those negative health effects will be undeniable...)
- think there's nothing they can do about the problem, or that the government is already doing enough...
In this 25,000+ words guide - broken up into several blog posts - I'll give you the power to take care of your air pollution exposure.
But let's consider why you should not wait for governments and (international) institutions to reduce the health effects of air pollution for you first...
A worldwide campaign has set a goal of halving air pollution deaths worldwide by 2030.[518] Halving air pollution deaths still entails that 4 million people are being killed on a yearly basis.
Many international treaties also tragically fail.
Example?
Consider the eight "Millennium Development Goals" that were set in the year 2000 for 2015. The only reason the poverty reduction goal was met is because of China's rapid economic development during that period.
Government policy had little to do with that accomplishment--more free markets did.
And even if governments and health institutions succeed in their goal of reducing air pollution by half, you'll still be exposed to dangerous levels.
An additional valid argument exists, however, that tells you why you should not wait for governments to rescue you:
Governments have (almost) no direct incentive to reduce air pollution.
Yes, really...
Why?
Reducing air pollution directly hurts economic development. Don't believe me?
Consider these examples:
Let's say you:
- no longer allow as many airplanes to fly from bigger cities. In that case, people will simply move to another airport and the less polluting city takes an economic hit.
- instate very high airplane pollution taxes in the US. As a response, US citizens may drive to Mexico and Canada to avoid pollution taxes - these pollution taxes directly hit the US economy.
- prevent polluting cars and trucks from entering cities. In that case, people will visit another city where their polluting diesel car may still venture. Prices of goods in the less polluted city may also increase because supply lines are harmed.
- strictly enforce lower air pollutant outputs from factories, ban industry from settling near residential zones, and necessitate industry to buy expensive filtering. Result? The competitive position of that industry goes down relative to other countries--hurting the country's economy.
- let 50% fewer cars enter cities or have all car owners buy a very expensive air filter on their car-exhaust. Consequence? Car transportation, which is central to the health of most economies, would go down.
There's no clear incentive to fully eliminate the problem of air pollution (yet)...
Advanced explanation: from an economic standpoint, the example given above is oversimplified. The health gains due to lowering air pollution also has advantages such as increased productivity and saving healthcare costs. In the short-term, however, pollution probably maximizes economic growth.
Solution: if you value your health, you have to take your air pollution exposure into your own hands.
Again, keep in mind that I'm not trying to make you depressed.
There's good news too:
Air quality has been improving in most of the developing world. Society-wide improvements in air quality are thus possible. Take a look at the levels of common air pollutants that are emitted in the United States:[20]
(Ammonia levels are not correctly displayed)
Observe:
Sulfur dioxide emissions have gone down 90%, and tiny particles numbers that are created as a byproduct of industry or transportation (PM2.5 and PM10) have almost halved.
(I'll tell you more about these pollutants in a moment...)
And there's more good news:
Even in more polluted countries such as India or China, the number of people dying from air pollution is steadily going down.
Sure, in absolute terms--because these countries' populations are growing--air pollution takes more lives than ever. Quantified as years of life that are lost per 100,000 inhabitants, however, deaths due to air pollution are going down.
But again: today air pollution levels are still negative for your health, and in 2030 the same is expected to be true.
A decline is not enough to save yourself--you'll want to minimize your exposure. My goal with this blog post series on air pollution is two-fold:
- Help you fully understand the problem of air pollution as well as most air pollutants.
- Reduce your air pollutant exposure as much as possible, up to a jaw-dropping 95%..
Please keep in mind that this ultimate guide is part of a wider series on the negative health effects of air pollution.
The previous installment of this series treated the topic of "particulate matter".
In that series, I claimed that you could reduce the negative effects of exposure dramatically by implementing a few solutions in your life, such as using air purifiers, planting vegetation, and avoiding "hot spot" locations of particulate matter.
Many of these solutions will return later in this blog post - in the fifth section I'll give you fifteen different solutions to reduce your inhaled level of air pollutants.
But first I'll tell you about the history of air pollution. The reason for including that history is that many people think that our ancestors were also exposed to toxic air every day.
Nothing could be further from the truth.
Let thus go back in time:
The History Of The Health Effects Of Air Pollution
Contrary to popular assumption, the negative health effects of air pollution didn't originate in the 19th century for us humans...
During the 19th century which contained the largest part of the Industrial Revolution, the number of factories grew exponentially. As a result, air pollution was created en masse (assuming you accept that there was such a "revolution" historically).
Air pollution is as old as humanity instead, and goes much farther back in time than humans have existed.
You can, for example, even make claim that dinosaurs became extinct because of air pollution.[5; 6; 7; 8]
Why?
66 million years ago a meteor 6-9 miles in diameter hit Mexico, creating the Chicxulub crater. Dust enveloped the earth as a result of the meteor impact (together with similarly timed volcanic eruptions) and cooled down the planet.
(Non-flying) dinosaurs were dependent on external heating from sunlight and could no longer survive.
75% of all other species went extinct as well. The health effects of air pollution are thus as old as this planet...
There's yet another reason to assume that air pollution arose much earlier than the 19th century:
Already by the discovery of creating fire, your human ancestors started polluting the air they're breathing.[9; 10; 11; 12]
The discovery of (intentionally using) fire occurred about 800,000 years ago, and our human species originated ~200,000 years ago.
Keep in mind that thus our it's your human-like ancestors - commonly called hominins - who learned to control fire first. Hominins are millions of years old
That control of fire does not exclusively have beneficial health effects. The obvious downside is that air pollutants are created.
The upside, of course, is that fires generate lots of heat. That heat helped our ancestors survive in colder environments such as Northern Europe.
But remember the dates I just gave you?
Essentially, the brain development of our ancestors started millions of years before the discovery of fire-control. During most of our hominin history air pollution was thus absent, except the pollution created by natural causes such as volcanoes and forest fires.
Let me give an example...
Your homo habilis ancestor who's shown below had a massively increased brain capacity compared to our common chimpanzee ancestors, and yet, did not control fire:
After the discovery of fire, fireplaces were used in caves. Fires in caves implies that your ancestors also exposed themselves to air pollution from that fire - smoke is very difficult to remove from caves.
Fast-forward a few million years:
At the onset of civilization and agriculture around 10,000 B.C., humans began to settle in one location. Fire then allowed for indoor cooking.
Of course, indoor fire was also used as heating sources, especially in colder areas of the globe.
The bad news?
Indoor cooking dramatically increases the air pollutants levels you're exposed to compared to creating fires outside.
It's thus simple to conclude that air pollution did thus not start in the 19th century...
For thousands of years, fires were one of the main sources of air pollution.
Other air pollution sources existed back then as well though. If you were a smith who was working bronze or iron, you'd be exposed to other toxins such as heavy metals.
Lead, a toxic heavy metal, was also used in construction and to preserve wine. Smelting that lead would have negatively affected your health, even though people didn't know about lead's harmful effects (yet) back then.
Air quality was surprisingly considered important back then, even though people did not fully understand why.
Some examples:[13]
- In ancient Greeks and Romans knew that inner-city air was of lower quality than the air found in nature outside the city
- Slave traders in the Age of Exploration discovered that slaves did not survive without sufficient ventilation
- Chimney sweeps had the reputation of being in poor health a few centuries ago
In the middle ages already, your ancestors also invented ways to make indoor fires less polluting.
A "Hearth" was invented, a central fireplace inside a home with an open hole in the roof so that most smoke could exit the building without polluting the entire room. Chimneys that direct the smoke directly away from the indoor environment were only invented in the 12th century.
The indoor usage of fireplaces remained relatively primitive well until the 18th century. For most of humanity's written history, indoor air pollution has thus been "part of the deal".
Only in the late 19th century, with the invention of electricity, was it no longer necessary to have a fireplace in each house for food preparation and heating.
Just seven generations ago, at the ending of the 18th century, the chemical revolution took place. Humans began to scientifically dissect components that are contained in the air and study their effects.
A French chemist called Antoine-Laurent de Lavoisier discovered (and named) oxygen as one of the gases that are subsumed in the air.
Before Lavoisier, other chemists had already discovered that there was no "uniform compound" which is "air". Instead, chemists knew that air actually is made up of several individual substances.
During the chemical revolution, different chemical elements were measured and categorized, which led to the possibility of studying individual substances subsumed into that air. In turn, that chemical revolution indirectly gave rise to the possibility of actively controlling that air...
A full understanding of air pollution, however, only developed slowly: the pollution problem became (much) worse before it got better. While some problematic periods of air pollution existed in big cities such as London between the 16th and 18th centuries, the air pollution problem really took off after that time.
Surprisingly, air pollution was mainly considered an "indoor" problem up until the beginning of the 20th century
Example:
Factory air pollution was unregulated at the beginning of the 20th century. That changed with a few developments in the 1950s and 1960s, when the harmful effects of air pollution became completely undeniable.
The great smog of London in 1952, during which lethal levels of sulfur dioxide were emitted into the air, killed a total of 10,000 people and made 100,000 ill. That smog led to the first wave of air quality regulations.[16; 17]
In 1962, a book called "Silent Spring" by Rachel Carson subsequently made the world aware of the side-effects of pesticide use.[18; 19]
Pesticides are also (partially) spread through the air...
From the 1950s and 60s of the 20th century, humans became painfully aware that their living environment did not just revolve around the house they were living in--the factory nearby, pesticides sprayed on your food or into the air, and traffic could poison the air you're breathing so that your health was affected.
Most people have nonetheless remained very complacent in controlling the air quality in their environment. From the 50s up until today, almost everyone assumes that air pollution is the government's task to deal with, not your individual responsibility.
(Hopefully that attitude will change after you read this guide)
And because of developments in the mid previous century, even teenagers are aware that air pollution affects their health today.
Ask any kid whether he considers smoking or breathing in car exhaust is healthy, and (s)he'll answer "no".
Two hundred years ago, people didn't know that air pollution was (that) damaging.
A simple analogy to understand that absence of knowledge can be made to bacteria and viruses: before the mid 19th century, medical practitioners were not aware of hygiene's importance, nor were bacteria or viruses identified separately.
Initially, viruses were even presumed to be the same thing as bacteria--until scientific experiments proved otherwise.[510] That distinction between viruses and bacteria nevertheless took time to be accepted by the scientific community.
The same is true for understanding air pollution...
Understanding of air pollution's health effects only slowly developed through the last few decades. That development is not done today, as new studies keep emerging. In some ways, air pollution is still misunderstood by the general public.
In developed nations, most people now assume that air quality is a problem that's located outside their homes. Scientific reality, on the contrary, shows that indoor air quality matters as much today as it did during (pre-)history.[13-15]
Why?
Modern human beings spend 90% of their time indoors. Indoor air pollutants levels can also be two to ten times as high as outdoors.[511-513]
How?
Simple:
In most cases, outdoor air pollutants simply enter buildings but never leave.
Talk about an unwelcome guest...
Let's therefore quickly determine whether you're affected by indoor air pollution as well. Consider this simple test:
- Is the air outside the building you're spending time in obviously polluted? (If you're living in a big city the answer is automatically "yes")
- Is it reasonable to assume that - because you're not actively dealing with the problem air pollution - that the air pollution ends up in your house?
If you answered "yes" twice, then congratulations: you can improve your health without having to spend thousands of hours in the gym, because indoor air pollution can be relatively straightforward to deal with in many cases.
In fact, simply integrating the solutions I'm suggesting later on in this blog post (section five) will guarantee improvement.
Let's, therefore, start digging into the problem of air pollution...
Oh, one last thing:
Since writing my previous blog post about reducing particulate matter exposure I've had questions about whether air pollution should not just be accepted as a "given".
That's a great question, actually, but my answer to that question is a resounding "no".
Consider exposure levels of "sulfur dioxide", a common byproduct of industrial processes that's emitted into the air:[20]
As you can see, sulfur dioxide levels were pretty low before the 1850s compared to the late 20th century.
99% of sulfur dioxide contained in the air today ended up there because of human action. So no, nature herself does not put extreme amounts of sulfur dioxide into the air (for longer periods of time).
Additionally, air pollution is also unhealthy, even when coming from natural sources. Air pollution should thus not be accepted as a given.
And of course, before the Industrial Revolution coal was also burned in homes - creating a sulfur dioxide problem. Nevertheless, the quantities emitted into the air only became extreme with the emergence of the factory system and mass burning of fossil fuels.
You're thus at greater danger today than in 17000, although the nature of your exposure has changed.
The bottom line is this: most air pollutants found in the air today were not present for your evolutionary ancestors in current quantities.
Again: you'll want to lower your exposure...
In the next section, I'll look at thirteen different types of air pollutants and their health effects.
Fasten your seat belt, because that section is going to be somewhat depressing...
By the way, want a no-fail strategy to reduce your air pollution exposure by up to 90%? Download my 10 air pollution laws infographic below:
Finishing Thoughts: Understanding The Problem To Find Solutions
I really hope you enjoyed this first introduction about how many air pollutants are subsumed in the air due to human action, and the history of air pollution.
Also, I hope you understand that air pollution isn't a simple side-issue that you can ignore if you want to optimize your health.
In the next installments of this blog post series, I'll go over many different air pollutants, tell you why they're important and what health consequences exist. I also offer specific options for reducing your exposure to air pollution, which can lower your exposure up to 99%!
So, despite the grave message in this blog post, there's a lot of room for hope!
This is a post by Bart Wolbers. Bart finished degrees in Physical Therapy (B), Philosophy (BA and MA), Philosophy of Science and Technology (MS - with distinction), and Clinical Health Science (MS), and is currently a health consultant at Alexfergus.com.
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[1] World Health Organization International. Air Pollution.
[2] Climate And Clean Air Coalition.
[3] BreatheLife Initiative 2030. A Global Campaign For Clean Air.
[4] Our World In Data. Air Pollution.
[5] Schlute P, Alegret L, ... Willumsen PS. The Chicxulub Asteroid Impact and Mass Extinction at the Cretaceous-Paleogene Boundary. Science Vol 327 2010.
[6] Longrich NR, Tokaryk T, Field DJ. Mass extinction of birds at the Cretaceous-Paleogene (K-Pg) boundary. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15253-7. doi: 10.1073/pnas.1110395108.
[7] Pope KO, D'Hondt SL, Marshall CR. Meteorite impact and the mass extinction of species at the Cretaceous/Tertiary boundary. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11028-9.
[8] Kaiho K, Oshima N. Site of asteroid impact changed the history of life on Earth: the low probability of mass extinction. Sci Rep. 2017 Nov 9;7(1):14855. doi: 10.1038/s41598-017-14199-x.
[9] Gowlett JA. The discovery of fire by humans: a long and convoluted process. Philos Trans R Soc Lond B Biol Sci. 2016 Jun 5;371(1696). pii: 20150164. doi: 10.1098/rstb.2015.0164.
[10] Cornélio AM, de Bittencourt-Navarrete RE, ... Costa MR. Human Brain Expansion during Evolution Is Independent of Fire Control and Cooking. Front Neurosci. 2016 Apr 25;10:167. doi: 10.3389/fnins.2016.00167. eCollection 2016.
[11] Roebroeks W, Villa P. On the earliest evidence for habitual use of fire in Europe. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5209-14. doi: 10.1073/pnas.1018116108. Epub 2011 Mar 14.
[12] MacDonald K. The use of fire and human distribution. Temperature (Austin). 2017 Jan 24;4(2):153-165. doi: 10.1080/23328940.2017.1284637. eCollection 2017.
[13] Sundell J. On the history of indoor air quality and health. Indoor Air. 2004;14 Suppl 7:51-8.
[14] Diffey BL. An overview analysis of the time people spend outdoors. Br J Dermatol. 2011 Apr;164(4):848-54. doi: 10.1111/j.1365-2133.2010.10165.x.
[15] Cincinelli A, Martellini T. Indoor Air Quality and Health. Int J Environ Res Public Health. 2017 Oct 25;14(11). pii: E1286. doi: 10.3390/ijerph14111286.
[16] Black J. Intussusception and the great smog of London, December 1952. Arch Dis Child. 2003 Dec;88(12):1040-2.
[17] Bell ML, Davis DL, Fletcher T. A retrospective assessment of mortality from the London smog episode of 1952: the role of influenza and pollution. Environ Health Perspect. 2004 Jan;112(1):6-8.
[18] Epstein L. Fifty years since Silent Spring. Annu Rev Phytopathol. 2014;52:377-402. doi: 10.1146/annurev-phyto-102313-045900. Epub 2014 Jun 16.
[19] Gay H. Before and after Silent Spring: from chemical pesticides to biological control and integrated pest management--Britain, 1945-1980. Ambix. 2012 Jul;59(2):88-108.
[20] Our World In Data. AIr Pollutoin. CC BY-SA copyright. Created by Hannah Ritchie and Max Roser. No changes made to the material. Lisence link: https://creativecommons.org/licenses/by-sa/4.0/deed.en_US
[21] Brimblecombe, P. London Air Pollution, 1500-1900. Atmospheric Environment. 1977 (11): 1157–1162.
[22] Smith, SJ, van Aardenne, J ... Delgado Arias S. Anthropogenic sulfur dioxide emissions: 1850–2005. 2011 Atmos. Chem. Phys., (11): 1101-1116
[23] Kao LW1, Nañagas KA. Carbon monoxide poisoning. Med Clin North Am. 2005 Nov;89(6):1161-94.
[24] Hanely ME, Patel PH. Carbon Monoxide Toxicity. StatPearls Publishing.
[25] Hampson NB. Carboxyhemoglobin: a primer for clinicians. Undersea Hyperb Med. 2018 Mar-Apr;45(2):165-171.
[26] Otterness K, Ahn C. Emergency department management of smoke inhalation injury in adults. Emerg Med Pract. 2018 Mar;20(3):1-24. Epub 2018 Mar 1.
[27] Gozubuyuk AA, Dag H, ... Arica V. Epidemiology, pathophysiology, clinical evaluation, and treatment of carbon monoxide poisoning in child, infant, and fetus. North Clin Istanb. 2017 May 10;4(1):100-107. doi: 10.14744/nci.2017.49368. eCollection 2017.
[28] Eizadi-Mood N, Alfred S, ... Moghadam AS. Comparison of arterial and capillary blood gas values in poisoning department assessment. Hum Exp Toxicol. 2009 Oct;28(10):665-70. doi: 10.1177/0960327109107001. Epub 2009 Sep 10.
[29] AuthorsBuboltz JB, Robins M. Hyperbaric, Carbon Monoxide Toxicity. StatPearls Publishing; 2018.
[30] Akcan Yildiz L, Gultekingil A, ... Teksam O. Predictors of Severe Clinical Course in Children With Carbon Monoxide Poisoning. Pediatr Emerg Care. 2018 Aug 13. doi: 10.1097/PEC.0000000000001580.
[31] Rose JJ, Nouraie M, ... Gladwin MT. Clinical Outcomes and Mortality Impact of Hyperbaric Oxygen Therapy in Patients With Carbon Monoxide Poisoning. Crit Care Med. 2018 Jul;46(7):e649-e655. doi: 10.1097/CCM.0000000000003135.
[32] Salvi A, Patki G, Liu H, Salim S. Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model. Sci Rep. 2017 Aug 16;7(1):8306. doi: 10.1038/s41598-017-08859-1.
[33] Hudda N, Fruin SA. Carbon dioxide accumulation inside vehicles: The effect of ventilation and driving conditions. Sci Total Environ. 2018 Jan 1;610-611:1448-1456. doi: 10.1016/j.scitotenv.2017.08.105. Epub 2017 Sep 1.
[34] Chiu CF, Chen MH, Chang FH. Carbon Dioxide Concentrations and Temperatures within Tour Buses under Real-Time Traffic Conditions. PLoS One. 2015 Apr 29;10(4):e0125117. doi: 10.1371/journal.pone.0125117. eCollection 2015.
[35] Lee GW, Bae MJ,... Lim YW. Decreased blood pressure associated with in-vehicle exposure to carbon monoxide in Korean volunteers. Environ Health Prev Med. 2017 Apr 5;22(1):34. doi: 10.1186/s12199-017-0622-y.
[36] Hampson NB, Holm JR, Courtney TG. Garage carbon monoxide levels from sources commonly used in intentional poisoning. Undersea Hyperb Med. 2017 Jan-Feb;44(1):11-15.
[37] Nayor M, Enserro DM, ... Seshadri S. Association of Exhaled Carbon Monoxide With Stroke Incidence and Subclinical Vascular Brain Injury: Framingham Heart Study. Stroke. 2016 Feb;47(2):383-9. doi: 10.1161/STROKEAHA.115.010405. Epub 2015 Dec 22.
[38] Levy RJ. Carbon monoxide pollution and neurodevelopment: A public health concern. Neurotoxicol Teratol. 2015 May-Jun;49:31-40. doi: 10.1016/j.ntt.2015.03.001. Epub 2015 Mar 13.
[39] Barn P, Giles L, ... Kosatsky T. A review of the experimental evidence on the toxicokinetics of carbon monoxide: the potential role of pathophysiology among susceptible groups. Environ Health. 2018 Feb 5;17(1):13. doi: 10.1186/s12940-018-0357-2.
[40] Lee FY, Chen WK, Lin CL, Kao CH. Carbon monoxide poisoning and subsequent cardiovascular disease risk: a nationwide population-based cohort study. Medicine (Baltimore). 2015 Mar;94(10):e624. doi: 10.1097/MD.0000000000000624.
[41] Lai CY, Huang YW, ... Kao CH. Patients With Carbon Monoxide Poisoning and Subsequent Dementia: A Population-Based Cohort Study. Medicine (Baltimore). 2016 Jan;95(1):e2418. doi: 10.1097/MD.0000000000002418.
[42] Wong CS, Lin YC, ... Wu MY. Increased Long-Term Risk of Dementia in Patients With Carbon Monoxide Poisoning: A Population-Based Study. Medicine (Baltimore). 2016 Jan;95(3):e2549. doi: 10.1097/MD.0000000000002549.
[43] Liu C, Yin P, ... Zhou M. Ambient carbon monoxide and cardiovascular mortality: a nationwide time-series analysis in 272 cities in China. Lancet Planet Health. 2018 Jan;2(1):e12-e18. doi: 10.1016/S2542-5196(17)30181-X. Epub 2018 Jan 9.
[44] Bartington SE, Bakolis I, ... Ayres JG. Patterns of domestic exposure to carbon monoxide and particulate matter in households using biomass fuel in Janakpur, Nepal. Environ Pollut. 2017 Jan;220(Pt A):38-45. doi: 10.1016/j.envpol.2016.08.074. Epub 2016 Oct 1.
[45] Mukhopadhyay S, Hirsch A, ... Orr M. Surveillance of carbon monoxide-related incidents - Implications for prevention of related illnesses and injuries, 2005-2014. Am J Emerg Med. 2018 Oct;36(10):1837-1844. doi: 10.1016/j.ajem.2018.02.011. Epub 2018 Feb 13.
[46] Watt S, Prado CE, Crowe SF. Immediate and Delayed Neuropsychological Effects of Carbon Monoxide Poisoning: A Meta-analysis. J Int Neuropsychol Soc. 2018 Apr;24(4):405-415. doi: 10.1017/S1355617717001035. Epub 2017 Oct 30.
[47] Hampson NB. Cost of accidental carbon monoxide poisoning: A preventable expense. Prev Med Rep. 2015 Dec 3;3:21-4. doi: 10.1016/j.pmedr.2015.11.010. eCollection 2016 Jun.
[48] Reboul C, Boissière J, ... Richard S. Carbon monoxide pollution aggravates ischemic heart failure through oxidative stress pathway. Sci Rep. 2017 Jan 3;7:39715. doi: 10.1038/srep39715.
[49] André L, Gouzi F, ... Cazorla O. Carbon monoxide exposure enhances arrhythmia after cardiac stress: involvement of oxidative stress. Basic Res Cardiol. 2011 Nov;106(6):1235-46. doi: 10.1007/s00395-011-0211-y. Epub 2011 Aug 6.
[50] Huang CC, Ho CH, ... Guo HR. Increased risk for diabetes mellitus in patients with carbon monoxide poisoning. Oncotarget. 2017 Jun 29;8(38):63680-63690. doi: 10.18632/oncotarget.18887. eCollection 2017 Sep 8.
[51] Lin CW, Chen WK, ... Kao CH. Association between ischemic stroke and carbon monoxide poisoning: A population-based retrospective cohort analysis. Eur J Intern Med. 2016 Apr;29:65-70. doi: 10.1016/j.ejim.2015.11.025. Epub 2015 Dec 17.
[52] McKenzie LB, Roberts KJ,... Gielen AC. Distribution and Evaluation of a Carbon Monoxide Detector Intervention in Two Settings: Emergency Department and Urban Community. J Environ Health. 2017 May;79(9):24-30.
[53] Wheeler-Martin K, Soghoian S, ... Hoffman RS. Impact of Mandatory Carbon Monoxide Alarms: An Investigation of the Effects on Detection and Poisoning Rates in New York City. Am J Public Health. 2015 Aug;105(8):1623-9. doi: 10.2105/AJPH.2015.302577. Epub 2015 Jun 11.
[54] Wong CS, Lin YC, ... Wu MY. Increased long-term risk of major adverse cardiovascular events in patients with carbon monoxide poisoning: A population-based study in Taiwan. PLoS One. 2017 Apr 25;12(4):e0176465. doi: 10.1371/journal.pone.0176465. eCollection 2017.
[55] Ozyurt A, Karpuz D, ... Hallioglu O. Effects of Acute Carbon Monoxide Poisoning on ECG and Echocardiographic Parameters in Children. Cardiovasc Toxicol. 2017 Jul;17(3):326-334. doi: 10.1007/s12012-016-9389-4.
[56] Sabzwari SR1, Fatmi Z. Comparison of exhaled carbon monoxide levels among commuters and roadside vendors in an urban and a suburban population in Pakistan. Environ Monit Assess. 2011 Sep;180(1-4):399-408. doi: 10.1007/s10661-010-1795-7. Epub 2010 Dec 2.
[57] Liu H, Tian Y, ... Hu Y. Association of short-term exposure to ambient carbon monoxide with hospital admissions in China. Sci Rep. 2018 Sep 6;8(1):13336. doi: 10.1038/s41598-018-31434-1.
[58] Eichhorn L, Michaelis D, ... Tetzlaff K. Carbon monoxide poisoning from waterpipe smoking: a retrospective cohort study. Clin Toxicol (Phila). 2018 Apr;56(4):264-272. doi: 10.1080/15563650.2017.1375115. Epub 2017 Sep 14.
[59] Maga M, Janik MK, ... Niżankowski R. Influence of air pollution on exhaled carbon monoxide levels in smokers and non-smokers. A prospective cross-sectional study. Environ Res. 2017 Jan;152:496-502. doi: 10.1016/j.envres.2016.09.004. Epub 2016 Oct 4.
[60] Tian L, Ho KF, ... Yu IT. Ambient carbon monoxide and the risk of hospitalization due to chronic obstructive pulmonary disease. Am J Epidemiol. 2014 Dec 15;180(12):1159-67. doi: 10.1093/aje/kwu248. Epub 2014 Dec 5.
[61] Lawin H, Ayi Fanou L, ... Sanni A. Exhaled carbon monoxide: a non-invasive biomarker of short-term exposure to outdoor air pollution. BMC Public Health. 2017 Apr 17;17(1):320. doi: 10.1186/s12889-017-4243-6.
[62] Huang CC, Ho CH, ... Guo HR. Hyperbaric Oxygen Therapy Is Associated With Lower Short- and Long-Term Mortality in Patients With Carbon Monoxide Poisoning. Chest. 2017 Nov;152(5):943-953. doi: 10.1016/j.chest.2017.03.049. Epub 2017 Apr 17.
[63] Dreyer-Andersen N, Almeida AS, ... Meyer M. Intermittent, low dose carbon monoxide exposure enhances survival and dopaminergic differentiation of human neural stem cells. PLoS One. 2018 Jan 16;13(1):e0191207. doi: 10.1371/journal.pone.0191207. eCollection 2018.
[64] Quinn AK, Ae-Ngibise KA, ... Asante KP. Association of Carbon Monoxide exposure with blood pressure among pregnant women in rural Ghana: Evidence from GRAPHS. Int J Hyg Environ Health. 2016 Mar;219(2):176-83. doi: 10.1016/j.ijheh.2015.10.004. Epub 2015 Nov 10.
[65] Yadav R, Sahu LK, ... Jaaffrey SNA. Ambient particulate matter and carbon monoxide at an urban site of India: Influence of anthropogenic emissions and dust storms. Environ Pollut. 2017 Jun;225:291-303. doi: 10.1016/j.envpol.2017.01.038. Epub 2017 Mar 25.
[66] Klepac P, Locatelli I, ... Kukec A. Ambient air pollution and pregnancy outcomes: A comprehensive review and identification of environmental public health challenges. Environ Res. 2018 Nov;167:144-159. doi: 10.1016/j.envres.2018.07.008. Epub 2018 Jul 5.
[67] Kim J, Han Y, ... Ahn K. Association of carbon monoxide levels with allergic diseases in children. Allergy Asthma Proc. 2016 Jan-Feb;37(1):e1-7. doi: 10.2500/aap.2016.37.3918.
[68] Li S, Guo Y, Williams G. Acute Impact of Hourly Ambient Air Pollution on Preterm Birth. Environ Health Perspect. 2016 Oct;124(10):1623-1629. Epub 2016 Apr 29.
[69] Alhanti BA, Chang HH, ... Sarnat SE. Ambient air pollution and emergency department visits for asthma: a multi-city assessment of effect modification by age. J Expo Sci Environ Epidemiol. 2016 Mar-Apr;26(2):180-8. doi: 10.1038/jes.2015.57. Epub 2015 Sep 9.
[70] Darby S, Hill D, ... Doll R. Radon in homes and risk of lung cancer: collaborative analysis of individual data from 13 European case-control studies. BMJ. 2005 Jan 29;330(7485):223. Epub 2004 Dec 21.
[71] Field RW, Steck DJ,... Lynch CF. Residential radon gas exposure and lung cancer: the Iowa Radon Lung Cancer Study. Am J Epidemiol. 2000 Jun 1;151(11):1091-102.
[72] Environmental Protection Agency. Assessment of Risks from Radon in Homes EPA 402-R-03-003.
[73] National Research Council (US) Committee on Risk Assessment of Exposure to Radon in Drinking Water. Risk Assessment of Radon in Drinking Water. Washington (DC): National Academies Press (US); 1999.
[74] Al-Zoughool M, Krewski D.Health effects of radon: a review of the literature. Int J Radiat Biol. 2009 Jan;85(1):57-69. doi: 10.1080/09553000802635054.
[75] Turner MC, Krewski D, ... Thun MJ. Radon and lung cancer in the American Cancer Society cohort. Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):438-48. doi: 10.1158/1055-9965.EPI-10-1153. Epub 2011 Jan 6.
[76] Turner MC, Krewski D, Chen Y, Pope CA 3rd, Gapstur SM, Thun MJ. Radon and COPD mortality in the American Cancer Society Cohort. Eur Respir J. 2012 May;39(5):1113-9. doi: 10.1183/09031936.00058211. Epub 2011 Oct 17.
[77] Peterson E, Aker A, Kim J, Li Y, Brand K, Copes R. Lung cancer risk from radon in Ontario, Canada: how many lung cancers can we prevent? Cancer Causes Control. 2013 Nov;24(11):2013-20. doi: 10.1007/s10552-013-0278-x. Epub 2013 Aug 28.
[78] Vienneau D1,2, de Hoogh K1,2, ... Röösli M. Effects of Radon and UV Exposure on Skin Cancer Mortality in Switzerland. Environ Health Perspect. 2017 Jun 16;125(6):067009. doi: 10.1289/EHP825.
[79] Groves-Kirkby CJ, Denman AR, ... Rogers S. Is environmental radon gas associated with the incidence of neurodegenerative conditions? A retrospective study of multiple sclerosis in radon affected areas in England and Wales. J Environ Radioact. 2016 Apr;154:1-14. doi: 10.1016/j.jenvrad.2015.12.003. Epub 2016 Jan 23.
[80] Peckham EC, Scheurer ME, ... Lupo PJ. Residential Radon Exposure and Incidence of Childhood Lymphoma in Texas, 1995-2011. Int J Environ Res Public Health. 2015 Sep 25;12(10):12110-26. doi: 10.3390/ijerph121012110.
[81] Auvinen A, Salonen L, ... Kurttio P. Radon and other natural radionuclides in drinking water and risk of stomach cancer: a case-cohort study in Finland. Int J Cancer. 2005 Mar 10;114(1):109-13.
[82] Darby S, Hill D, ... Doll R. Residential radon and lung cancer--detailed results of a collaborative analysis of individual data on 7148 persons with lung cancer and 14,208 persons without lung cancer from 13 epidemiologic studies in Europe. Scand J Work Environ Health. 2006;32 Suppl 1:1-83.
[83] Laurier D, Valenty M, Tirmarche M. Radon exposure and the risk of leukemia: a review of epidemiological studies. Health Phys. 2001 Sep;81(3):272-88.
[84] Ajrouche R, Ielsch G, ... Le Tertre A. Quantitative Health Risk Assessment of Indoor Radon: A Systematic Review. Radiat Prot Dosimetry. 2017 Nov 1;177(1-2):69-77. doi: 10.1093/rpd/ncx152.
[85] Torres-Durán M, Barros-Dios JM, Fernández-Villar A, Ruano-Ravina A. Residential radon and lung cancer in never smokers. A systematic review. Cancer Lett. 2014 Apr 1;345(1):21-6. doi: 10.1016/j.canlet.2013.12.010. Epub 2013 Dec 11.
[86] Vogeltanz-Holm N, Schwartz GG. Radon and lung cancer: What does the public really know? J Environ Radioact. 2018 Dec;192:26-31. doi: 10.1016/j.jenvrad.2018.05.017. Epub 2018 Jun 5.
[87] Garcia-Rodriguez JA. Radon gas-the hidden killer: What is the role of family doctors? Can Fam Physician. 2018 Jul;64(7):496-501.
[88] Ravina AR, Dacosta-Urbieta A, ... Kelsey KT. Radon exposure and tumors of the central nervous system. Gaceta Sanitaria 2017.
[89] Ruano-Ravina A, Aragonés N ... Barros-Dios JM. Residential radon exposure and brain cancer: an ecological study in a radon prone area (Galicia, Spain). Sci Rep. 2017 Jun 15;7(1):3595. doi: 10.1038/s41598-017-03938-9.
[90] EPA. Home Buyer’s and Seller’s Guide to Radon. EPA 402/K-13/002 March 2018.
[91] World Health Organization. Handbook on Indoor Radon: A Public Health Perspective, 2009.
[92] Faustini A, Rapp R, Forastiere F. Nitrogen dioxide and mortality: review and meta-analysis of long-term studies. Eur Respir J. 2014 Sep;44(3):744-53. doi: 10.1183/09031936.00114713. Epub 2014 Feb 20.
[93] Eisner MD, Anthonisen N, ... Environmental and Occupational Health Assembly. An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Sep 1;182(5):693-718. doi: 10.1164/rccm.200811-1757ST.
[94] Zhang Z, Wang J, Lu W. Exposure to nitrogen dioxide and chronic obstructive pulmonary disease (COPD) in adults: a systematic review and meta-analysis. Environ Sci Pollut Res Int. 2018 May;25(15):15133-15145. doi: 10.1007/s11356-018-1629-7. Epub 2018 Mar 20.
[95] Gong H Jr, Linn WS, ... Sioutas C. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhal Toxicol. 2005 Mar;17(3):123-32.
[96] Belanger K, Holford TR, ... Leaderer BP. Household levels of nitrogen dioxide and pediatric asthma severity. Epidemiology. 2013 Mar;24(2):320-30. doi: 10.1097/EDE.0b013e318280e2ac.
[97] Health Effects Institute. Traffic-Related Air Pollution: A Critical Review of the Literature on Emissions, Exposure, and Health Effects. 2010.
[98] Hoek G, Krishnan RM, ... Kaufman JD. Long-term air pollution exposure and cardio- respiratory mortality: a review. Environ Health. 2013 May 28;12(1):43. doi: 10.1186/1476-069X-12-43.
[99] Atkinson RW, Butland BK, Anderson HR, Maynard RL. Long-term Concentrations of Nitrogen Dioxide and Mortality: A Meta-analysis of Cohort Studies. Epidemiology. 2018 Jul;29(4):460-472. doi: 10.1097/EDE.0000000000000847.
[100] Sun J, Barnes AJ, He D, Wang M, Wang J. Systematic Review and Meta-Analysis of the Association between Ambient Nitrogen Dioxide and Respiratory Disease in China. Int J Environ Res Public Health. 2017 Jun 16;14(6). pii: E646. doi: 10.3390/ijerph14060646.
[101] Mills IC, Atkinson RW, ... Anderson HR. Quantitative systematic review of the associations between short-term exposure to nitrogen dioxide and mortality and hospital admissions. BMJ Open. 2015 May 11;5(5):e006946. doi: 10.1136/bmjopen-2014-006946.
[102] Hamra GB, Laden F, ... Loomis D. Lung Cancer and Exposure to Nitrogen Dioxide and Traffic: A Systematic Review and Meta-Analysis. Environ Health Perspect. 2015 Nov;123(11):1107-12. doi: 10.1289/ehp.1408882. Epub 2015 Apr 14.
[103] Luo K, Li R,... Xu Q. Acute Effects of Nitrogen Dioxide on Cardiovascular Mortality in Beijing: An Exploration of Spatial Heterogeneity and the District-specific Predictors. Sci Rep. 2016 Dec 2;6:38328. doi: 10.1038/srep38328.
[104] Cepeda M, Schoufour J, ... Franco OH. Levels of ambient air pollution according to mode of transport: a systematic review. Lancet Public Health. 2017 Jan;2(1):e23-e34. doi: 10.1016/S2468-2667(16)30021-4. Epub 2016 Nov 26.
[105] Yang BY, Qian Z, ... Dong GH. Global association between ambient air pollution and blood pressure: A systematic review and meta-analysis. Environ Pollut. 2018 Apr;235:576-588. doi: 10.1016/j.envpol.2018.01.001. Epub 2018 Jan 11.
[106] German Environment Agency. Quantifizierung von umweltbedingten Krankheitslasten aufgrund der Stickstoffdioxid-Exposition in Deutschland, 2018.
[107] UK Department For Environment, Food, And Rural Affairs. Draft plans to improve air quality in the UK Tackling nitrogen dioxide in our towns and cities. 2015.
[108] Committee on the Medical Effects of Air Pollutants.
[109] Zhao T, Markevych I, ... Heinrich J. Ambient ozone exposure and mental health: A systematic review of epidemiological studies. Environ Res. 2018 Aug;165:459-472. doi: 10.1016/j.envres.2018.04.015. Epub 2018 May 1.
[110] Mendola P, Ha S, ... Liu D. Chronic and Acute Ozone Exposure in the Week Prior to Delivery Is Associated with the Risk of Stillbirth. Int J Environ Res Public Health. 2017 Jul 6;14(7). pii: E731. doi: 10.3390/ijerph14070731.
[111] Atkinson RW, Butland BK, ... Anderson HR. Long-term exposure to ambient ozone and mortality: a quantitative systematic review and meta-analysis of evidence from cohort studies. BMJ Open. 2016 Feb 23;6(2):e009493. doi: 10.1136/bmjopen-2015-009493.
[112] Yin P, Chen R, ... Kan H. Ambient Ozone Pollution and Daily Mortality: A Nationwide Study in 272 Chinese Cities. Environ Health Perspect. 2017 Nov 21;125(11):117006. doi: 10.1289/EHP1849.
[113] Bell ML, Zanobetti A, Dominici F. Who is more affected by ozone pollution? A systematic review and meta-analysis. Am J Epidemiol. 2014 Jul 1;180(1):15-28. doi: 10.1093/aje/kwu115. Epub 2014 May 28.
[114] Koman PD, Mancuso P. Ozone Exposure, Cardiopulmonary Health, and Obesity: A Substantive Review. Chem Res Toxicol. 2017 Jul 17;30(7):1384-1395. doi: 10.1021/acs.chemrestox.7b00077. Epub 2017 Jun 15.
[115] Jerrett M, Burnett RT, ... Thun M. Long-term ozone exposure and mortality. N Engl J Med. 2009 Mar 12;360(11):1085-95. doi: 10.1056/NEJMoa0803894.
[116] Goodman JE, Zu K, ... Sax SN. Short-term ozone exposure and asthma severity: Weight-of-evidence analysis. Environ Res. 2018 Jan;160:391-397. doi: 10.1016/j.envres.2017.10.018.
[117] Shah AS, Langrish JP, ... Mills NL. Global association of air pollution and heart failure: a systematic review and meta-analysis. Lancet. 2013 Sep 21;382(9897):1039-48. doi: 10.1016/S0140-6736(13)60898-3. Epub 2013 Jul 10.
[118] Zhang B, Zhao J, Yang ... Yang S. Ozone and Other Air Pollutants and the Risk of Congenital Heart Defects. Sci Rep. 2016 Oct 18;6:34852. doi: 10.1038/srep34852.
[119] Srebot V, Gianicolo EA, Rainaldi G, Trivella MG, Sicari R. Ozone and cardiovascular injury. Cardiovasc Ultrasound. 2009 Jun 24;7:30. doi: 10.1186/1476-7120-7-30.
[120] Goodman JE, Prueitt RL, ... Venditti FJ. Ozone exposure and systemic biomarkers: Evaluation of evidence for adverse cardiovascular health impacts. Crit Rev Toxicol. 2015 May;45(5):412-52. doi: 10.3109/10408444.2015.1031371.
[121] Mirowsky JE, Carraway MS, ... Devlin RB. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. Environ Health. 2017 Nov 21;16(1):126. doi: 10.1186/s12940-017-0335-0.
[122] WHO Regional Office Europe. Review of evidence on health aspects of air pollution – REVIHAAP Project: Technical Report: BHealth effects of ozone.
[123] Medina-Ramón M, Schwartz J. Who is more vulnerable to die from ozone air pollution? Epidemiology. 2008 Sep;19(5):672-9. doi: 10.1097/EDE.0b013e3181773476.
[124] Sawyer K, Brown JS, Hazucha MJ, Bennett WD. The effect of exercise on nasal uptake of ozone in healthy human adults. J Appl Physiol (1985). 2007 Apr;102(4):1380-6. Epub 2006 Nov 2.
[125] Stafoggia M1, Forastiere F, ... Perucci CA; EpiAir Group. Susceptibility factors to ozone-related mortality: a population-based case-crossover analysis. Am J Respir Crit Care Med. 2010 Aug 1;182(3):376-84. doi: 10.1164/rccm.200908-1269OC. Epub 2010 Mar 25.
[126] Turner MC, Jerrett M, ... Burnett RT. Long-Term Ozone Exposure and Mortality in a Large Prospective Study. Am J Respir Crit Care Med. 2016 May 15;193(10):1134-42. doi: 10.1164/rccm.201508-1633OC.
[127] Alexeeff SE, Litonjua AA, ... Schwartz J. Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study. Chest. 2007 Dec;132(6):1890-7. Epub 2007 Oct 9.
[128] McDonnell WF, Stewart PW, Smith MV. Prediction of ozone-induced lung function responses in humans. Inhal Toxicol. 2010 Feb;22(2):160-8. doi: 10.3109/08958370903089557.
[129] Lin S, Liu X, Le LH, Hwang SA. Chronic exposure to ambient ozone and asthma hospital admissions among children. Environ Health Perspect. 2008 Dec;116(12):1725-30. doi: 10.1289/ehp.11184. Epub 2008 Sep 10.
[130] Bell ML, McDermott A, ... Dominici F. Ozone and short-term mortality in 95 US urban communities, 1987-2000. JAMA. 2004 Nov 17;292(19):2372-8.
[131] Gryparis A, Forsberg B, ... Dörtbudak Z. Acute effects of ozone on mortality from the "air pollution and health: a European approach" project. Am J Respir Crit Care Med. 2004 Nov 15;170(10):1080-7. Epub 2004 Jul 28.
[132] Bell ML, Dominici F, Samet JM. A meta-analysis of time-series studies of ozone and mortality with comparison to the national morbidity, mortality, and air pollution study. Epidemiology. 2005 Jul;16(4):436-45.
[133] Levy JI, Chemerynski SM, Sarnat JA. Ozone exposure and mortality: an empiric bayes metaregression analysis. Epidemiology. 2005 Jul;16(4):458-68.
[134] Ito K, De Leon SF, Lippmann M. Associations between ozone and daily mortality: analysis and meta-analysis. Epidemiology. 2005 Jul;16(4):446-57.
[135] Zanobetti A, Schwartz J. Mortality displacement in the association of ozone with mortality: an analysis of 48 cities in the United States. Am J Respir Crit Care Med. 2008 Jan 15;177(2):184-9. Epub 2007 Oct 11.
[136] Samoli E, Zanobetti A, ... Katsouyanni K. The temporal pattern of mortality responses to ambient ozone in the APHEA project. J Epidemiol Community Health. 2009 Dec;63(12):960-6. doi: 10.1136/jech.2008.084012. Epub 2009 Jul 30.
[137] Gong H, Wong R,... Prasad SB. Cardiovascular effects of ozone exposure in human volunteers. Am J Respir Crit Care Med. 1998 Aug;158(2):538-46.
[138] Rich DQ, Balmes JR, ... Bromberg PA. Cardiovascular function and ozone exposure: The Multicenter Ozone Study in oldEr Subjects (MOSES). Environ Int. 2018 Oct;119:193-202. doi: 10.1016/j.envint.2018.06.014. Epub 2018 Jul 4.
[139] Frampton MW, Pietropaoli A, ... Utell MJ. Cardiovascular effects of ozone in healthy subjects with and without deletion of glutathione-S-transferase M1. Inhal Toxicol. 2015 Feb;27(2):113-9. doi: 10.3109/08958378.2014.996272.
[140] Stenfors N, Pourazar J, ... Sandström T. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med. 2002 May;96(5):352-8.
[141] Golden JA, Nadel JA, Boushey HA. Bronchial hyperirritability in healthy subjects after exposure to ozone. Am Rev Respir Dis. 1978 Aug;118(2):287-94.
[142] Di Q, Dai L, ... Dominici F. Association of Short-term Exposure to Air Pollution With Mortality in Older Adults. JAMA. 2017 Dec 26;318(24):2446-2456. doi: 10.1001/jama.2017.17923.
[143] Parker JD, Akinbami LJ, Woodruff TJ. Air pollution and childhood respiratory allergies in the United States. Environ Health Perspect. 2009 Jan;117(1):140-7. doi: 10.1289/ehp.11497. Epub 2008 Sep 30.
[144] Frank U, Ernst D. Effects of NO2 and Ozone on Pollen Allergenicity. Front Plant Sci. 2016 Feb 4;7:91. doi: 10.3389/fpls.2016.00091. eCollection 2016.
[145] Khatri SB, Holguin FC, ... Teague WG. Association of ambient ozone exposure with airway inflammation and allergy in adults with asthma. J Asthma. 2009 Oct;46(8):777-85.
[146] Takizawa H. Impact of air pollution on allergic diseases. Korean J Intern Med. 2011 Sep;26(3):262-73. doi: 10.3904/kjim.2011.26.3.262. Epub 2011 Sep 13.
[147] Zhang Q, Qiu Z, Chung KF, Huang SK. Link between environmental air pollution and allergic asthma: East meets West. J Thorac Dis. 2015 Jan;7(1):14-22. doi: 10.3978/j.issn.2072-1439.2014.12.07.
[148] Rufo JC, Madureira J, Fernandes EO, Moreira A. Volatile organic compounds in asthma diagnosis: a systematic review and meta-analysis. Allergy. 2016 Feb;71(2):175-88. doi: 10.1111/all.12793. Epub 2015 Nov 13.
[149] Ho DX, Kim KH, Sohn JR, Oh YH, Ahn JW. Emission rates of volatile organic compounds released from newly produced household furniture products using a large-scale chamber testing method. ScientificWorldJournal. 2011;11:1597-622. doi: 10.1100/2011/650624. Epub 2011 Sep 8.
[150] Nurmatov UB, Tagiyeva N, Semple S, Devereux G, Sheikh A. Volatile organic compounds and risk of asthma and allergy: a systematic review. Eur Respir Rev. 2015 Mar;24(135):92-101. doi: 10.1183/09059180.00000714.
[151] Paciência I, Madureira J,... Fernandes Ede O. A systematic review of evidence and implications of spatial and seasonal variations of volatile organic compounds (VOC) in indoor human environments. J Toxicol Environ Health B Crit Rev. 2016;19(2):47-64. doi: 10.1080/10937404.2015.1134371. Epub 2016 May 10.
[152] Zhang J, Smith KR. Indoor air pollution: a global health concern. Br Med Bull. 2003;68:209-25.
[153] Franklin PJ. Indoor air quality and respiratory health of children. Paediatr Respir Rev. 2007 Dec;8(4):281-6. Epub 2007 Oct 31.
[154] Dales R, Raizenne M. Residential exposure to volatile organic compounds and asthma. J Asthma. 2004;41(3):259-70.
[155] Krzyzanowski M, Quackenboss JJ, Lebowitz MD. Chronic respiratory effects of indoor formaldehyde exposure. Environ Res. 1990 Aug;52(2):117-25.
[156] Jaakkola JJ, Verkasalo PK, Jaakkola N. Plastic wall materials in the home and respiratory health in young children. Am J Public Health. 2000 May;90(5):797-9.
[157] Rumchev K, Spickett J,... Stick S. Association of domestic exposure to volatile organic compounds with asthma in young children. Thorax. 2004 Sep;59(9):746-51.
[158] Rumchev KB, Spickett JT, ... Stick SM.Domestic exposure to formaldehyde significantly increases the risk of asthma in young children. Eur Respir J. 2002 Aug;20(2):403-8.
[159] Brown SK. Chamber assessment of formaldehyde and VOC emissions from wood-based panels. Indoor Air. 1999 Sep;9(3):209-15.
[160] Wang JX, Shen J, Lei CS, Feng Q. Volatile organic compound and formaldehyde emissions from Populus davidiana wood treated with low molecular weight urea-formaldehyde resin. J Environ Biol. 2014 Sep;35(5):989-94.
[161] Guo H, Kwok NH, ... Li YS. Formaldehyde and volatile organic compounds in Hong Kong homes: concentrations and impact factors. Indoor Air. 2009 Jun;19(3):206-17. doi: 10.1111/j.1600-0668.2008.00580.x. Epub 2009 Feb 7.
[162] Lee K, Choi JH,... Son BS. Indoor levels of volatile organic compounds and formaldehyde from emission sources at elderly care centers in Korea. PLoS One. 2018 Jun 7;13(6):e0197495. doi: 10.1371/journal.pone.0197495. eCollection 2018.
[163] Wolkoff P, Wilkins CK, Clausen PA, Nielsen GD. Organic compounds in office environments - sensory irritation, odor, measurements and the role of reactive chemistry. Indoor Air. 2006 Feb;16(1):7-19.
[164] Joshi SM. The sick building syndrome. Indian J Occup Environ Med. 2008 Aug;12(2):61-4. doi: 10.4103/0019-5278.43262.
[165] Dick FD. Solvent neurotoxicity. Occup Environ Med. 2006 Mar;63(3):221-6, 179.
[166] Shuai J, Kim S, ... Yang W. Health risk assessment of volatile organic compounds exposure near Daegu dyeing industrial complex in South Korea. BMC Public Health. 2018 Apr 20;18(1):528. doi: 10.1186/s12889-018-5454-1.
[167] Ma CM, Lin LY,... Chuang KJ. Volatile organic compounds exposure and cardiovascular effects in hair salons. Occup Med (Lond). 2010 Dec;60(8):624-30. doi: 10.1093/occmed/kqq128. Epub 2010 Sep 5.
[168] St Helen G, Jacob P, ... Benowitz NL. Intake of toxic and carcinogenic volatile organic compounds from secondhand smoke in motor vehicles. Cancer Epidemiol Biomarkers Prev. 2014 Dec;23(12):2774-82. doi: 10.1158/1055-9965.EPI-14-0548. Epub 2014 Nov 14.
[169] Yoon HI, Hong YC, ... Cheong HK. Exposure to volatile organic compounds and loss of pulmonary function in the elderly. Eur Respir J. 2010 Dec;36(6):1270-6. doi: 10.1183/09031936.00153509. Epub 2010 Mar 29.
[170] Elliott L, Longnecker MP, Kissling GE, London SJ. Volatile organic compounds and pulmonary function in the Third National Health and Nutrition Examination Survey, 1988-1994. Environ Health Perspect. 2006 Aug;114(8):1210-4.
[171] Ran J, Qiu H, Sun S, Yang A, Tian L. Are ambient volatile organic compounds environmental stressors for heart failure? Environ Pollut. 2018 Nov;242(Pt B):1810-1816. doi: 10.1016/j.envpol.2018.07.086. Epub 2018 Jul 27.
[172] Lang AL, Beier JI. Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem. 2018 Oct 25;399(11):1237-1248. doi: 10.1515/hsz-2017-0324.
[173] Liu J, Drane W, Liu X, Wu T. Examination of the relationships between environmental exposures to volatile organic compounds and biochemical liver tests: application of canonical correlation analysis. Environ Res. 2009 Feb;109(2):193-9. doi: 10.1016/j.envres.2008.11.002. Epub 2008 Dec 30.
[174] Malaguarnera G, Cataudella E, ... Malaguarnera M. Toxic hepatitis in occupational exposure to solvents. World J Gastroenterol. 2012 Jun 14;18(22):2756-66. doi: 10.3748/wjg.v18.i22.2756.
[175] Chang TY, Huang KH, ... Bao BY. Exposure to volatile organic compounds and kidney dysfunction in thin film transistor liquid crystal display (TFT-LCD) workers. J Hazard Mater. 2010 Jun 15;178(1-3):934-40. doi: 10.1016/j.jhazmat.2010.02.027. Epub 2010 Feb 18.
[176] Meinardi S, Jin KB, ... Vaziri ND. Exhaled breath and fecal volatile organic biomarkers of chronic kidney disease. Biochim Biophys Acta. 2013 Mar;1830(3):2531-7.
[177] Batterman S, Su FC, Li S, Mukherjee B, Jia C; HEI Health Review Committee. Personal exposure to mixtures of volatile organic compounds: modeling and further analysis of the RIOPA data. Res Rep Health Eff Inst. 2014 Jun;(181):3-63.
[178] Gallagher M, Wysocki CJ, ... Preti G. Analyses of volatile organic compounds from human skin. Br J Dermatol. 2008 Sep;159(4):780-91. doi: 10.1111/j.1365-2133.2008.08748.x. Epub 2008 Jul 14.
[179] Gostner JM, Zeisler J, ... Überall F. Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
[180] Creta M, Poels K, ... Vanoirbeek JAJ. A Method to Quantitatively Assess Dermal Exposure to Volatile Organic Compounds. Ann Work Expo Health. 2017 Oct 1;61(8):975-985. doi: 10.1093/annweh/wxx054.
[181] World Health Organization. Burden of disease from Ambient Air Pollution for 2012.
[182] Lim SS, Vos T, ... Memish ZA. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012 Dec 15;380(9859):2224-60. doi: 10.1016/S0140-6736(12)61766-8.
[183] Schulz H. Fine particulate matter - a health hazard for lungs and other organs?. Pneumologie. 2006 Oct;60(10):611-5.
[184] Yoshizaki K, Brito JM, ... Macchione M. The effects of particulate matter on inflammation of respiratory system: Differences between male and female. Sci Total Environ. 2017 May 15;586:284-295. doi: 10.1016/j.scitotenv.2017.01.221. Epub 2017 Feb 4.
[185] Tamagawa E, Bai N, ... van Eeden SF. Particulate matter exposure induces persistent lung inflammation and endothelial dysfunction. Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L79-85. doi: 10.1152/ajplung.00048.2007. Epub 2008 May 9.
[186] Grunig G, Marsh LM, ... Park SH. Perspective: ambient air pollution: inflammatory response and effects on the lung's vasculature. Pulm Circ. 2014 Mar;4(1):25-35. doi: 10.1086/674902.
[187] Seaton A, Soutar A, ... Stout R. Particulate air pollution and the blood. Thorax. 1999 Nov;54(11):1027-32.
[188] Sørensen M, Daneshvar B, ... Loft S. Personal PM2.5 exposure and markers of oxidative stress in blood. Environ Health Perspect. 2003 Feb;111(2):161-6.
[189] Wang T, Chiang ET, ... Garcia JG. Particulate matter disrupts human lung endothelial barrier integrity via ROS- and p38 MAPK-dependent pathways. Am J Respir Cell Mol Biol. 2010 Apr;42(4):442-9. doi: 10.1165/rcmb.2008-0402OC. Epub 2009 Jun 11.
[190] Wang T, Wang L, ... Garcia JG. Particulate matter air pollution disrupts endothelial cell barrier via calpain-mediated tight junction protein degradation. Part Fibre Toxicol. 2012 Aug 29;9:35. doi: 10.1186/1743-8977-9-35.
[191] Zeka A, Zanobetti A, Schwartz J. Short term effects of particulate matter on cause specific mortality: effects of lags and modification by city characteristics. Occup Environ Med. 2005 Oct;62(10):718-25.
[192] Atkinson RW, Mills IC, Walton HA, Anderson HR. Fine particle components and health--a systematic review and meta-analysis of epidemiological time series studies of daily mortality and hospital admissions. J Expo Sci Environ Epidemiol. 2015 Mar-Apr;25(2):208-14. doi:10.1038/jes.2014.63. Epub 2014 Sep 17.
[193] Kloog I, Ridgway B, ... Schwartz JD. Long- and short-term exposure to PM2.5 and mortality: using novel exposure models. Epidemiology. 2013 Jul;24(4):555-61. doi:
[194] Mills IC, Atkinson RW, ... Strachan DP. Distinguishing the associations between daily mortality and hospital admissions and nitrogen dioxide from those of particulate matter: a systematic review and meta-analysis. BMJ Open. 2016 Jul 21;6(7):e010751. doi: 10.1136/bmjopen-2015-010751.
[195] Pelucchi C, Negri E, ... La Vecchia C. Long-term particulate matter exposure and mortality: a review of European epidemiological studies. BMC Public Health. 2009 Dec 8;9:453. doi: 10.1186/1471-2458-9-453.
[196] Li T, Yan M, Sun Q, Anderson GB. Mortality risks from a spectrum of causes associated with wide-ranging exposure to fine particulate matter: A case-crossover study in Beijing, China. Environ Int. 2018 Feb;111:52-59. doi: 10.1016/j.envint.2017.10.023. Epub 2017 Nov 22.
[197] Newell K, Kartsonaki C, Lam KBH, Kurmi OP. Cardiorespiratory health effects of particulate ambient air pollution exposure in low-income and middle-income countries: a systematic review and meta-analysis. Lancet Planet Health. 2017 Dec;1(9):e368-e380. doi: 10.1016/S2542-5196(17)30166-3. Epub 2017 Dec 8.
[198] Requia WJ, Adams MD, ... Mahmoud M. Global Association of Air Pollution and Cardiorespiratory Diseases: A Systematic Review, Meta-Analysis, and Investigation of Modifier Variables. Am J Public Health. 2018 Apr;108(S2):S123-S130. doi: 10.2105/AJPH.2017.303839. Epub 2017 Oct 26.
[199] Li J, Sun S, ... Tian L. Major air pollutants and risk of COPD exacerbations: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 2016 Dec 12;11:3079-3091. doi: 10.2147/COPD.S122282. eCollection 2016.
[200] Liu Q, Xu C, ... Zhao P. Effect of exposure to ambient PM2.5 pollution on the risk of respiratory tract diseases: a meta-analysis of cohort studies. J Biomed Res. 2017 Jan 19;31(2):130-142. doi: 10.7555/JBR.31.20160071.
[201] Hamra GB, Guha N, ... Loomis D. Outdoor particulate matter exposure and lung cancer: a systematic review and meta-analysis. Environ Health Perspect. 2014 Sep;122(9):906-11. doi: 10.1289/ehp.1408092. Epub 2014 Jun 6.
[202] Roy A, Hu W, Wei F, Korn L, Chapman RS, Zhang JJ. Ambient particulate matter and lung function growth in Chinese children. Epidemiology. 2012 May;23(3):464-72. doi:
[203] Koenig JQ, Larson TV, ... Pierson WE. Pulmonary function changes in children associated with fine particulate matter. Environ Res. 1993 Oct;63(1):26-38.
[204] Kim JH, Lim DH, Kim JK, Jeong SJ, Son BK. Effects of particulate matter (PM10) on the pulmonary function of middle-school children. J Korean Med Sci. 2005 Feb;20(1):42-5.
[205] Chen H, Goldberg MS, Villeneuve PJ. A systematic review of the relation between long-term exposure to ambient air pollution and chronic diseases. Rev Environ Health. 2008 Oct-Dec;23(4):243-97.
[206] ] Lim YH, Bae HJ, ... Hong YC. Vascular and cardiac autonomic function and PM2.5 constituents among the elderly: A longitudinal study. Sci Total Environ. 2017 Dec 31;607-608:847-854. doi: 10.1016/j.scitotenv.2017.07.077. Epub 2017 Jul 27.
[207] Kim H, Kim J, ... Chae IH. Cardiovascular Effects of Long-Term Exposure to Air Pollution: A Population-Based Study With 900 845 Person-Years of Follow-up. J Am Heart Assoc. 2017 Nov 8;6(11). pii: e007170. doi: 10.1161/JAHA.117.007170.
[208] Martinelli N, Olivieri O, Girelli D. Air particulate matter and cardiovascular disease: a narrative review. Eur J Intern Med. 2013 Jun;24(4):295-302. doi: 10.1016/j.ejim.2013.04.001. Epub 2013 May 4.
[209] Fiordelisi A, Piscitelli P, ... Sorriento D. The mechanisms of air pollution and particulate matter in cardiovascular diseases. Heart Fail Rev. 2017 May;22(3):337-347. doi: 10.1007/s10741-017-9606-7.
[210] Li H, Cai J, ... Kan H. Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification. Circulation. 2017 Aug 15;136(7):618-627. doi: 10.1161/CIRCULATIONAHA.116.026796.
[211] Hicken MT, Dvonch JT, Schulz AJ, Mentz G, Max P. Fine particulate matter air pollution and blood pressure: the modifying role of psychosocial stress. Environ Res. 2014 Aug;133:195-203. doi: 10.1016/j.envres.2014.06.001. Epub 2014 Jun 24.
[212] Borchers AT, Chang C, Eric Gershwin M. Mold and Human Health: a Reality Check. Clin Rev Allergy Immunol. 2017 Jun;52(3):305-322. doi: 10.1007/s12016-017-8601-z.
[213] Edmondson DA, Nordness ME, Zacharisen MC, Kurup VP, Fink JN. Allergy and "toxic mold syndrome". Ann Allergy Asthma Immunol. 2005 Feb;94(2):234-9.
[214] Valtonen V. Clinical Diagnosis of the Dampness and Mold Hypersensitivity Syndrome: Review of the Literature and Suggested Diagnostic Criteria. Front Immunol. 2017 Aug 10;8:951. doi: 10.3389/fimmu.2017.00951. eCollection 2017.
[215] Brewer JH, Thrasher JD, Hooper D. Chronic illness associated with mold and mycotoxins: is naso-sinus fungal biofilm the culprit? Toxins (Basel). 2013 Dec 24;6(1):66-80. doi: 10.3390/toxins6010066.
[216] Bennett JW1, Klich M. Mycotoxins. Clin Microbiol Rev. 2003 Jul;16(3):497-516.
[217] Rosenblum Lichtenstein JH, Hsu YH, ... Brain JD. Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses. PLoS One. 2015 May 26;10(5):e0126926. doi: 10.1371/journal.pone.0126926. eCollection 2015.
[218] World Health Organization. WHO guidelines for indoor air quality: dampness and mould.
[219] Palma N, Cinelli S, ... Dogliotti E. Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress. Chem Res Toxicol. 2007 Jul;20(7):1031-7. Epub 2007 Jun 14.
[220] Monnet-Tschudi F, Zurich MG, ... Schilter B. The naturally occurring food mycotoxin fumonisin B1 impairs myelin formation in aggregating brain cell culture. Neurotoxicology. 1999 Feb;20(1):41-8.
[221] Doi K, Uetsuka K. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. Int J Mol Sci. 2011;12(8):5213-37. doi: 10.3390/ijms12085213. Epub 2011 Aug 15.
[222] Bossou YM, Serssar Y, ... Achard S. Impact of Mycotoxins Secreted by Aspergillus Molds on the Inflammatory Response of Human Corneal Epithelial Cells. Toxins (Basel). 2017 Jun 22;9(7). pii: E197. doi: 10.3390/toxins9070197.
[223] Daschner A. An Evolutionary-Based Framework for Analyzing Mold and Dampness-Associated Symptoms in DMHS. Front Immunol. 2017 Jan 9;7:672. doi: 10.3389/fimmu.2016.00672. eCollection 2016.
[224] Aiko V, Mehta A. Occurrence, detection and detoxification of mycotoxins. J Biosci. 2015 Dec;40(5):943-54.
[225] Rosenblum Lichtenstein JH, Molina RM, ... Brain JD. Repeated Mouse Lung Exposures to Stachybotrys chartarum Shift Immune Response from Type 1 to Type 2. Am J Respir Cell Mol Biol. 2016 Oct;55(4):521-531.
[226] Tuuminen T, Rinne KS. Severe Sequelae to Mold-Related Illness as Demonstrated in Two Finnish Cohorts. Front Immunol. 2017 Apr 3;8:382. doi: 10.3389/fimmu.2017.00382. eCollection 2017.
[227] Bartrip PW. History of asbestos related disease. Postgrad Med J. 2004 Feb;80(940):72-6.
[228] Lemen RA. Introduction: history of the use of asbestos. Med Lav. 1997 Jul-Aug;88(4):288-92.
[229] The David Law Firm. Shipyards, a Crucible for Tragedy Part 1: How the war created a monster. 2001.
[230] Nielsen LS, Bælum J, ... Sherson D. Occupational asbestos exposure and lung cancer--a systematic review of the literature. Arch Environ Occup Health. 2014;69(4):191-206. doi: 10.1080/19338244.2013.863752.
[231] Kang D, Myung MS, Kim YK, Kim JE. Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults. Ann Occup Environ Med. 2013 Jul 8;25(1):10. doi: 10.1186/2052-4374-25-10.
[232] Wilken D, Velasco Garrido M, Manuwald U, Baur X. Lung function in asbestos-exposed workers, a systematic review and meta-analysis. J Occup Med Toxicol. 2011 Jul 26;6:21. doi: 10.1186/1745-6673-6-21.
[233] Ngamwong Y, Tangamornsuksan W, ...Lohitnavy M. Additive Synergism between Asbestos and Smoking in Lung Cancer Risk: A Systematic Review and Meta-Analysis. PLoS One. 2015 Aug 14;10(8):e0135798. doi: 10.1371/journal.pone.0135798. eCollection 2015.
[234] Ollier M, Chamoux A, ... Dutheil F. Chest CT scan screening for lung cancer in asbestos occupational exposure: a systematic review and meta-analysis. Chest. 2014 Jun;145(6):1339-1346. doi: 10.1378/chest.13-2181.
[235] Neri M, Ugolini D ... Bonassi S. Chemoprevention of asbestos-linked cancers: a systematic review. Anticancer Res. 2012 Mar;32(3):1005-13.
[236] LaDou J. The asbestos cancer epidemic. Environ Health Perspect. 2004 Mar;112(3):285-90.
[237] Khalade A, Jaakkola MS, Pukkala E, Jaakkola JJ. Exposure to benzene at work and the risk of leukemia: a systematic review and meta-analysis. Environ Health. 2010 Jun 28;9:31. doi: 10.1186/1476-069X-9-31.
[238] D'Andrea MA, Reddy GK. Health Risks Associated With Benzene Exposure in Children: A Systematic Review. Glob Pediatr Health. 2018 Aug 17;5:2333794X18789275. doi: 10.1177/2333794X18789275. eCollection 2018.
[239] Smith MT. Advances in understanding benzene health effects and susceptibility. Annu Rev Public Health. 2010;31:133-48 2 p following 148. doi: 10.1146/annurev.publhealth.012809.103646.
[240] Gist GL, Burg JR. Benzene--a review of the literature from a health effects perspective. Toxicol Ind Health. 1997 Nov-Dec;13(6):661-714.
[241] Wiwanitkit V. Benzene exposure and hypertension: an observation. Cardiovasc J Afr. 2007 Jul-Aug;18(4):264-5.
[242] Wiwanitkit V. Headaches in subjects occupationally exposed to benzene vapors. J Headache Pain. 2008 Aug;9(4):253-4. doi: 10.1007/s10194-008-0041-y. Epub 2008 May 7.
[243] Edokpolo B, Yu QJ, Connell D. Health risk characterization for exposure to benzene in service stations and petroleum refineries environments using human adverse response data. Toxicol Rep. 2015 Jun 5;2:917-927. doi: 10.1016/j.toxrep.2015.06.004. eCollection 2015.
[244] Kataria A, Trasande L, Trachtman H. The effects of environmental chemicals on renal function. Nat Rev Nephrol. 2015 Oct;11(10):610-25. doi: 10.1038/nrneph.2015.94. Epub 2015 Jun 23.
[245] Neghab M, Hosseinzadeh K, Hassanzadeh J. Early Liver and Kidney Dysfunction Associated with Occupational Exposure to Sub-Threshold Limit Value Levels of Benzene, Toluene, and Xylenes in Unleaded Petrol. Saf Health Work. 2015 Dec;6(4):312-6. doi: 10.1016/j.shaw.2015.07.008. Epub 2015 Aug 5.
[246] Snyder R, Hedli CC. An overview of benzene metabolism. Environ Health Perspect. 1996 Dec;104 Suppl 6:1165-71.
[247] Rana SV, Verma Y. Biochemical toxicity of benzene. J Environ Biol. 2005 Apr;26(2):157-68.
[248] Lanphear BP, Hornung R, ... Roberts R. Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ Health Perspect. 2005 Jul;113(7):894-9.
[249] Canfield RL, Henderson CR Jr, ... Lanphear BP. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med. 2003 Apr 17;348(16):1517-26.
[250] Schwartz J. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res. 1994 Apr;65(1):42-55.
[251] Wani AL, Ara A, Usmani JA. Lead toxicity: a review. Interdiscip Toxicol. 2015 Jun;8(2):55-64. doi: 10.1515/intox-2015-0009.
[252] Sokol RZ, Berman N. The effect of age of exposure on lead-induced testicular toxicity. Toxicology. 1991;69(3):269-78.
[253] Staudinger KC, Roth VS. Occupational lead poisoning. Am Fam Physician. 1998 Feb 15;57(4):719-26, 731-2.
[254] Sanborn MD, Abelsohn A, Campbell M, Weir E. Identifying and managing adverse environmental health effects: 3. Lead exposure. CMAJ. 2002 May 14;166(10):1287-92.
[255] Reuben A, Caspi A, ... Moffitt TE. Association of Childhood Blood Lead Levels With Cognitive Function and Socioeconomic Status at Age 38 Years and With IQ Change and Socioeconomic Mobility Between Childhood and Adulthood. JAMA. 2017 Mar 28;317(12):1244-1251. doi: 10.1001/jama.2017.1712.
[256] Liu J, Liu X, ... Dinges D. Early Blood Lead Levels and Sleep Disturbance in Preadolescence. Sleep. 2015 Dec 1;38(12):1869-74. doi: 10.5665/sleep.5230.
[257] Bouchard MF, Bellinger DC, ... Weisskopf MG. Blood lead levels and major depressive disorder, panic disorder, and generalized anxiety disorder in US young adults. Arch Gen Psychiatry. 2009 Dec;66(12):1313-9. doi: 10.1001/archgenpsychiatry.2009.164.
[258] Mudipalli A. Lead hepatotoxicity & potential health effects. Indian J Med Res. 2007 Dec;126(6):518-27.
[259] Flora G, Gupta D, Tiwari A. Toxicity of lead: A review with recent updates. Interdiscip Toxicol. 2012 Jun;5(2):47-58. doi: 10.2478/v10102-012-0009-2.
[260] Rastogi SK Renal effects of environmental and occupational lead exposure. Indian J Occup Environ Med. 2008 Dec;12(3):103-6. doi: 10.4103/0019-5278.44689
[261] Radosevic Z, Saric M, ... Knezevic J. The kidney in lead poisoning. Br J Ind Med. 1961 Jul;18:222-30.
[262] Ferreira de Mattos G, Costa C, ... Nicolson GL. Lead poisoning: acute exposure of the heart to lead ions promotes changes in cardiac function and Cav1.2 ion channels. Biophys Rev. 2017 Oct;9(5):807-825. doi: 10.1007/s12551-017-0303-5. Epub 2017 Aug 23.
[263] Navas-Acien A, Guallar E, Silbergeld EK, Rothenberg SJ. Lead exposure and cardiovascular disease--a systematic review. Environ Health Perspect. 2007 Mar;115(3):472-82. Epub 2006 Dec 22.
[264] Neal AP, Guilarte TR. Mechanisms of lead and manganese neurotoxicity. Toxicol Res (Camb). 2013 Mar 1;2(2):99-114.
[265] Sanders T, Liu Y, Buchner V, Tchounwou PB. Neurotoxic effects and biomarkers of lead exposure: a review. Rev Environ Health. 2009 Jan-Mar;24(1):15-45.
[266] Komarnicki GJ. Lead and cadmium in indoor air and the urban environment. Environ Pollut. 2005 Jul;136(1):47-61.
[267] Stewart-Pinkham SM. The effect of ambient cadmium air pollution on the hair mineral content of children. Sci Total Environ. 1989 Jan;78:289-96.
[268] Hyder O, Chung M,... Pawlik TM. Cadmium exposure and liver disease among US adults. J Gastrointest Surg. 2013 Jul;17(7):1265-73. doi: 10.1007/s11605-013-2210-9. Epub 2013 May 1.
[269] Kang MY, Cho SH, Lim YH, Seo JC, Hong YC. Effects of environmental cadmium exposure on liver function in adults. Occup Environ Med. 2013 Apr;70(4):268-73. doi: 10.1136/oemed-2012-101063. Epub 2013 Jan 15.
[270] Johri N, Jacquillet G, Unwin R. Heavy metal poisoning: the effects of cadmium on the kidney. Biometals. 2010 Oct;23(5):783-92. doi: 10.1007/s10534-010-9328-y. Epub 2010 Mar 31.
[271] Satarug S. Dietary Cadmium Intake and Its Effects on Kidneys. Toxics. 2018 Mar 10;6(1). pii: E15. doi: 10.3390/toxics6010015.
[272] Buser MC, Ingber SZ, ... Scinicariello F. Urinary and blood cadmium and lead and kidney function: NHANES 2007-2012. Int J Hyg Environ Health. 2016 May;219(3):261-7. doi: 10.1016/j.ijheh.2016.01.005. Epub 2016 Jan 28.
[273] Wallin M, Sallsten G, Lundh T, Barregard L. Low-level cadmium exposure and effects on kidney function. Occup Environ Med. 2014 Dec;71(12):848-54. doi: 10.1136/oemed-2014-102279. Epub 2014 Oct 6.
[274] Byber K, Lison D, ... Hotz P. Cadmium or cadmium compounds and chronic kidney disease in workers and the general population: a systematic review. Crit Rev Toxicol. 2016;46(3):191-240. doi: 10.3109/10408444.2015.1076375. Epub 2015 Oct 29.
[275] Minami A, Takeda A, ... Oku N. Cadmium toxicity in synaptic neurotransmission in the brain. Brain Res. 2001 Mar 16;894(2):336-9.
[276] Rinaldi M, Micali A, ... Minutoli L. Cadmium, Organ Toxicity and Therapeutic Approaches: A Review on Brain, Kidney and Testis Damage. Curr Med Chem. 2017 Nov 20;24(35):3879-3893. doi: 10.2174/0929867324666170801101448.
[277] Wang B, Du Y. Cadmium and its neurotoxic effects. Oxid Med Cell Longev. 2013;2013:898034. doi: 10.1155/2013/898034. Epub 2013 Aug 12.
[278] Benoff S, Jacob A, Hurley IR. Male infertility and environmental exposure to lead and cadmium. Hum Reprod Update. 2000 Mar-Apr;6(2):107-21.
[279] Pollack AZ, Ranasinghe S, Sjaarda LA, Mumford SL. Cadmium and Reproductive Health in Women: A Systematic Review of the Epidemiologic Evidence. Curr Environ Health Rep. 2014 Jun;1(2):172-184. Epub 2014 Mar 21.
[280] Paksy K, Varga B, Lázár P. Effect of cadmium on female fertility, pregnancy and postnatal development in the rat. Acta Physiol Hung. 1996;84(2):119-30.
[281] Benoff S, Hauser R, ... Centola GM. Cadmium concentrations in blood and seminal plasma: correlations with sperm number and motility in three male populations (infertility patients, artificial insemination donors, and unselected volunteers). Mol Med. 2009 Jul-Aug;15(7-8):248-62. doi: 10.2119/molmed.2008.00104.
[282] de Angelis C, Galdiero M, ... Pivonello R. The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility. Reprod Toxicol. 2017 Oct;73:105-127. doi: 10.1016/j.reprotox.2017.07.021. Epub 2017 Aug 1.
[283] Saksena SK, Lau IF. Effects of cadmium chloride on testicular steroidogenesis and fertility of male rats. Endokrinologie. 1979 Apr;74(1):6-12.
[284] Adamkovicova M, Toman R, ... Massanyi P. Sperm motility and morphology changes in rats exposed to cadmium and diazinon. Reprod Biol Endocrinol. 2016 Aug 8;14(1):42. doi: 10.1186/s12958-016-0177-6.
[285] Zhao X, Cheng Z, ... Luo Y. Effects of paternal cadmium exposure on the sperm quality of male rats and the neurobehavioral system of their offspring. Exp Ther Med. 2015 Dec;10(6):2356-2360. Epub 2015 Sep 25.
[286] Gennart JP, Buchet JP, ... Lauwerys R. Fertility of male workers exposed to cadmium, lead, or manganese. Am J Epidemiol. 1992 Jun 1;135(11):1208-19.
[287] Hartwig A. Cadmium and cancer. Met Ions Life Sci. 2013;11:491-507. doi: 10.1007/978-94-007-5179-8_15.
[288] Huff J, Lunn RM, Waalkes MP, Tomatis L, Infante PF. Cadmium-induced cancers in animals and in humans. Int J Occup Environ Health. 2007 Apr-Jun;13(2):202-12.
[289] García-Esquinas E, Pollan M, ... Navas-Acien A. Cadmium exposure and cancer mortality in a prospective cohort: the strong heart study. Environ Health Perspect. 2014 Apr;122(4):363-70. doi: 10.1289/ehp.1306587. Epub 2014 Feb 14.
[290] Chen C, Xun P, ... He K. Cadmium exposure and risk of prostate cancer: a meta-analysis of cohort and case-control studies among the general and occupational populations. Sci Rep. 2016 May 13;6:25814. doi: 10.1038/srep25814.
[291] Gallagher CM, Chen JJ, Kovach JS. Environmental cadmium and breast cancer risk. Aging (Albany NY). 2010 Nov;2(11):804-14.
[292] Mascagni P, Consonni D, ... Toffoletto F. Olfactory function in workers exposed to moderate airborne cadmium levels. Neurotoxicology. 2003 Aug;24(4-5):717-24.
[293] Bernard A. Cadmium & its adverse effects on human health. Indian J Med Res. 2008 Oct;128(4):557-64.
[294] Thun MJ, Osorio AM, ... Halperin W. Nephropathy in cadmium workers: assessment of risk from airborne occupational exposure to cadmium. Br J Ind Med. 1989 Oct;46(10):689-97.
[295] Lauwerys R, Bernard A,... Amery A. Does environmental exposure to cadmium represent a health risk? Conclusions from the Cadmibel study. Acta Clin Belg. 1991;46(4):219-25.
[296] Bonino S. Carbon Dioxide Detection and Indoor Air Quality Control. Occup Health Saf. 2016 Apr;85(4):46-8.
[297] Vehviläinen T, Lindholm H, ... Vinha J. High indoor CO2 concentrations in an office environment increases the transcutaneous CO2 level and sleepiness during cognitive work. J Occup Environ Hyg. 2016;13(1):19-29. doi: 10.1080/15459624.2015.1076160.
[298] Gaihre S, Semple S, ... Turner S. Classroom carbon dioxide concentration, school attendance, and educational attainment. J Sch Health. 2014 Sep;84(9):569-74. doi: 10.1111/josh.12183.
[299] Fromme H, Heitmann D, ... Twardella D. Air quality in schools - classroom levels of carbon dioxide (CO2), volatile organic compounds (VOC), aldehydes, endotoxins and cat allergen. Gesundheitswesen. 2008 Feb;70(2):88-97. doi: 10.1055/s-2008-1046775.
[300] Muscatiello N, McCarthy A, ... Lin S. Classroom conditions and CO2 concentrations and teacher health symptom reporting in 10 New York State Schools. Indoor Air. 2015 Apr;25(2):157-67. doi: 10.1111/ina.12136. Epub 2014 Jul 14.
[301] Tsai DH, Lin JS, Chan CC. Office workers' sick building syndrome and indoor carbon dioxide concentrations. J Occup Environ Hyg. 2012;9(5):345-51. doi: 10.1080/15459624.2012.675291.
[302] Lu CY, Lin JM, Chen YY, Chen YC. Building-Related Symptoms among Office Employees Associated with Indoor Carbon Dioxide and Total Volatile Organic Compounds. Int J Environ Res Public Health. 2015 May 27;12(6):5833-45. doi: 10.3390/ijerph120605833.
[303] Heebøll A, Wargocki P, Toftum J. Window and door opening behavior, carbon dioxide concentration, temperature, and energy use during the heating season in classrooms with different ventilation retrofits—ASHRAE RP1624. Science and Technology for the Built Environment 24(6) 2014.
[304] Satish U, Mendell MJ, ... Fisk WJ. Is CO2 an indoor pollutant? Direct effects of low-to-moderate CO2 concentrations on human decision-making performance. Environ Health Perspect. 2012 Dec;120(12):1671-7. doi: 10.1289/ehp.1104789. Epub 2012 Sep 20.
[305] Shendell DG, Prill R, ... Faulkner D. Associations between classroom CO2 concentrations and student attendance in Washington and Idaho. Indoor Air. 2004 Oct;14(5):333-41.
[306] Allen JG, MacNaughton P,... Spengler JD. Associations of Cognitive Function Scores with Carbon Dioxide, Ventilation, and Volatile Organic Compound Exposures in Office Workers: A Controlled Exposure Study of Green and Conventional Office Environments. Environ Health Perspect. 2016 Jun;124(6):805-12. doi: 10.1289/ehp.1510037. Epub 2015 Oct 26.
[307] Zhang X, Wargocki P, Lian Z, Thyregod C. Effects of exposure to carbon dioxide and bioeffluents on perceived air quality, self-assessed acute health symptoms, and cognitive performance. Indoor Air. 2017 Jan;27(1):47-64. doi: 10.1111/ina.12284. Epub 2016 Mar 7.
[308] Arlian LG, Neal JS, Vyszenski-Moher DL. Fluctuating hydrating and dehydrating relative humidities effects on the life cycle of Dermatophagoides farinae (Acari: Pyroglyphidae). J Med Entomol. 1999 Jul;36(4):457-61.
[309] Arlian LG, Alexander AK, ... Vyszenski-Moher DL. Reducing indoor humidity significantly reduces dust mites and allergen in homes. In: Proceedings of the European Academy of Allergy & Clinical Immunology Meeting, 2000.
[310] Vyszenski-Moher DL, Neal JS, ... Arlian LG. Maintaining low RH reduces dust mite and allergen levels in homes. Presented at the Entomological Society of America Meeting, 2000 Montreal.
[311] Vyszenski-Moher DL , Arlian LG, Neal JS. Effects of laundry detergents on Dermatophagoides farinae, Dermatophagoides pteronyssinus, and Euroglyphus maynei. Ann Allergy Asthma Immunol. 2002 Jun;88(6):578-83.
[312] Arlian LG1, Neal JS, ... Alexander AK. Reducing relative humidity is a practical way to control dust mites and their allergens in homes in temperate climates. J Allergy Clin Immunol. 2001 Jan;107(1):99-104.
[313] Arlian LG, Neal JS, Vyszenski-Moher DL. Reducing relative humidity to control the house dust mite Dermatophagoides farinae. J Allergy Clin Immunol. 1999 Oct;104(4 Pt 1):852-6.
[314] Wang IJ, Tung TH, Tang CS, Zhao ZH. Allergens, air pollutants, and childhood allergic diseases. Int J Hyg Environ Health. 2016 Jan;219(1):66-71. doi: 10.1016/j.ijheh.2015.09.001. Epub 2015 Sep 18.
[315] Bartra J, Mullol J, ... Valero A. Air pollution and allergens. J Investig Allergol Clin Immunol. 2007;17 Suppl 2:3-8.
[316] Carrer P, Maroni M, Alcini D, Cavallo D. Allergens in indoor air: environmental assessment and health effects. Sci Total Environ. 2001 Apr 10;270(1-3):33-42.
[317] Castañeda AR, Vogel CFA, ... Pinkerton KE. Ambient particulate matter enhances the pulmonary allergic immune response to house dust mite in a BALB/c mouse model by augmenting Th2- and Th17-immune responses. Physiol Rep. 2018 Sep;6(18):e13827. doi: 10.14814/phy2.13827.
[318] Castañeda AR, Bein KJ, ... Pinkerton KE. Fine particulate matter (PM2.5) enhances allergic sensitization in BALB/c mice. J Toxicol Environ Health A. 2017;80(4):197-207. doi: 10.1080/15287394.2016.1222920. Epub 2017 May 11.
[319] Wu JZ, Ge DD, ... Li QY. Effects of particulate matter on allergic respiratory diseases. Chronic Dis Transl Med. 2018 Jun 8;4(2):95-102. doi: 10.1016/j.cdtm.2018.04.001. eCollection 2018 Jun.
[320] Erbas B, Jazayeri M, ... Dharmage SC. Outdoor pollen is a trigger of child and adolescent asthma emergency department presentations: A systematic review and meta-analysis. Allergy. 2018 Aug;73(8):1632-1641. doi: 10.1111/all.13407. Epub 2018 Mar 2.
[321] Jensen-Jarolim E, Pali-Schöll I, Kinaciyan T. Caution: Reptile pets shuttle grasshopper allergy and asthma into homes. World Allergy Organization Journal 2015 8:72.
[322] Dharmage SC, Lodge CL, Matheson MC, Campbell B, Lowe AJ. Exposure to cats: update on risks for sensitization and allergic diseases. Curr Allergy Asthma Rep. 2012 Oct;12(5):413-23. doi: 10.1007/s11882-012-0288-x.
[323] Konradsen JR, Nordlund B, ... Hedlin G. Severe childhood asthma and allergy to furry animals: Refined assessment using molecular‐based allergy diagnostics. Asthma in childhood 25(2).
[324] Burton OT, Oettgen HC. Beyond immediate hypersensitivity: evolving roles for IgE antibodies in immune homeostasis and allergic diseases. Immunol Rev. 2011 Jul;242(1):128-43. doi: 10.1111/j.1600-065X.2011.01024.x.
[325] Platts-Mills TA. The allergy epidemics: 1870-2010. J Allergy Clin Immunol. 2015 Jul;136(1):3-13. doi: 10.1016/j.jaci.2015.03.048.
[326] Braun-Fahrländer C, Lauener R. Farming and protective agents against allergy and asthma. Clin Exp Allergy. 2003 Apr;33(4):409-11.
[327] Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA. 2002 Aug 28;288(8):963-72.
[328] Lødrup Carlsen KC, Roll S, ... Keil T. Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS One. 2012;7(8):e43214. doi: 10.1371/journal.pone.0043214. Epub 2012 Aug 29.
[329] Dunn RR, Fierer N, Henley JB, Leff JW, Menninger HL. Home life: factors structuring the bacterial diversity found within and between homes. PLoS One. 2013 May 22;8(5):e64133. doi: 10.1371/journal.pone.0064133. Print 2013.
[330] Yang MS, Lee SP, Kwon YJ, Lee SM. Dog and Cat Allergies and Allergen Avoidance Measures in Korean Adult Pet Owners Who Participated in a Pet Exhibition. Allergy Asthma Immunol Res. 2018 Mar;10(2):155-164. doi: 10.4168/aair.2018.10.2.155.
[331] Informed Health Online. Dust mite allergies: Overview. 2017.
[332] Miller JD. The Role of Dust Mites in Allergy. Clin Rev Allergy Immunol. 2018 Jun 23. doi: 10.1007/s12016-018-8693-0.
[333] Cinteza M, Daian C. House dust mite - the paradox. Maedica (Buchar). 2014 Dec;9(4):313-5.
[334] Kemp TJ, Siebers RW, ... Crane J. House dust mite allergen in pillows. BMJ. 1996 Oct 12;313(7062):916.
[335] Dryer AL, Chandler MJ, Hamilton RG. Dust-mite allergen removal from feathers by commercial processing. Ann Allergy Asthma Immunol. 2002 Jun;88(6):576-7.
[336] Vojta PJ, Randels SP,... Zeldin DC. Effects of physical interventions on house dust mite allergen levels in carpet, bed, and upholstery dust in low-income, urban homes. Environ Health Perspect. 2001 Aug;109(8):815-9.
[337] Casley LS, Godec T, ... Dewhirst SY. How clean is your house? A study of house dust mites, allergens and other contents of dust samples collected from households. Int J Environ Health Res. 2018 Aug;28(4):341-357. doi: 10.1080/09603123.2018.1457141. Epub 2018 Jun 22.
[338] Ciprandi G, Puccinelli P, ... Italian Cometa Study Group. The relevance of house dust mites allergy in clinical practice: the epidemiological impact on allergen immunotherapy. Immunotherapy. 2017 Nov;9(15):1219-1224. doi: 10.2217/imt-2017-0086.
[339] Dzoro S, Mittermann I, ... Valenta R. House dust mites as potential carriers for IgE sensitization to bacterial antigens. Allergy. 2018 Jan;73(1):115-124. doi: 10.1111/all.13260. Epub 2017 Sep 7.
[340] Valmonte GR, Cauyan GA, Ramos JD. IgE cross-reactivity between house dust mite allergens and Ascaris lumbricoides antigens. Asia Pac Allergy. 2012 Jan;2(1):35-44. doi: 10.5415/apallergy.2012.2.1.35. Epub 2012 Jan 10.
[341] Wong L, Huang CH, Lee BW. Shellfish and House Dust Mite Allergies: Is the Link Tropomyosin? Allergy Asthma Immunol Res. 2016 Mar;8(2):101-6. doi: 10.4168/aair.2016.8.2.101. Epub 2015 Jul 14.
[342] de Boer R, Kuller K. Mattresses as a winter refuge for house-dust mite populations. Allergy. 1997 Mar;52(3):299-305.
[343] Arruda LK, Vailes LD, ... Chapman MD. Cockroach allergens and asthma. J Allergy Clin Immunol. 2001 Mar;107(3):419-28.
[344] Sohn MH, Kim KE. The cockroach and allergic diseases. Allergy Asthma Immunol Res. 2012 Sep;4(5):264-9. doi: 10.4168/aair.2012.4.5.264. Epub 2012 May 22.
[345] Do DC, Zhao Y, Gao P. Cockroach allergen exposure and risk of asthma. Allergy. 2016 Apr;71(4):463-74. doi: 10.1111/all.12827. Epub 2016 Feb 4.
[346] Pomés A, Mueller GA, ... Arruda LK. New Insights into Cockroach Allergens. Curr Allergy Asthma Rep. 2017 Apr;17(4):25. doi: 10.1007/s11882-017-0694-1.
[347] Panzner P, Vachová M, ... Malý M. Cross-sectional study on sensitization to mite and cockroach allergen components in allergy patients in the Central European region. Clin Transl Allergy. 2018 Jun 4;8:19. doi: 10.1186/s13601-018-0207-x. eCollection 2018.
[348] Pomés A, Arruda LK. Investigating cockroach allergens: aiming to improve diagnosis and treatment of cockroach allergic patients. Methods. 2014 Mar 1;66(1):75-85. doi: 10.1016/j.ymeth.2013.07.036. Epub 2013 Aug 2.
[349] Zoratti EM, Krouse RZ, ... Liu AH. Asthma phenotypes in inner-city children. J Allergy Clin Immunol. 2016 Oct;138(4):1016-1029. doi: 10.1016/j.jaci.2016.06.061.
[350] Gergen PJ , Togias A. Inner city asthma. Immunol Allergy Clin North Am. 2015 Feb;35(1):101-14. doi: 10.1016/j.iac.2014.09.006. Epub 2014 Oct 18.
[351] Newell K, Kartsonaki C, Lam KBH, Kurmi O. Cardiorespiratory health effects of gaseous ambient air pollution exposure in low and middle income countries: a systematic review and meta-analysis. Environ Health. 2018 Apr 18;17(1):41. doi: 10.1186/s12940-018-0380-3.
[352] Zhao R, Chen S, ... Wei S. The impact of short-term exposure to air pollutants on the onset of out-of-hospital cardiac arrest: A systematic review and meta-analysis. Int J Cardiol. 2017 Jan 1;226:110-117. doi: 10.1016/j.ijcard.2016.10.053. Epub 2016 Oct 25.
[353] Song X, Liu Y, ... Wang S. Short-Term Exposure to Air Pollution and Cardiac Arrhythmia: A Meta-Analysis and Systematic Review. Int J Environ Res Public Health. 2016 Jun 28;13(7). pii: E642. doi: 10.3390/ijerph13070642.
[354] Uzoigwe JC, Prum T, Bresnahan E, Garelnabi M. The emerging role of outdoor and indoor air pollution in cardiovascular disease. N Am J Med Sci. 2013 Aug;5(8):445-53. doi: 10.4103/1947-2714.117290.
[355] Kan H, Wong CM, Vichit-Vadakan N, Qian Z; PAPA Project Teams. Short-term association between sulfur dioxide and daily mortality: the Public Health and Air Pollution in Asia (PAPA) study. Environ Res. 2010 Apr;110(3):258-64. doi: 10.1016/j.envres.2010.01.006. Epub 2010 Feb 1.
[356] Sunyer J, Atkinson R, ... APHEA 2 study. Respiratory effects of sulphur dioxide: a hierarchical multicity analysis in the APHEA 2 study. Occup Environ Med. 2003 Aug;60(8):e2.
[357] Lai HK, Tsang H, Wong CM. Meta-analysis of adverse health effects due to air pollution in Chinese populations. BMC Public Health. 2013 Apr 18;13:360. doi: 10.1186/1471-2458-13-360.
[358] Hehua Z, Qing C, Shanyan G, Qijun W, Yuhong Z. The impact of prenatal exposure to air pollution on childhood wheezing and asthma: A systematic review. Environ Res. 2017 Nov;159:519-530. doi: 10.1016/j.envres.2017.08.038. Epub 2017 Sep 8.
[359] Siddika N, Balogun HA, Amegah AK, Jaakkola JJ. Prenatal ambient air pollution exposure and the risk of stillbirth: systematic review and meta-analysis of the empirical evidence. Occup Environ Med. 2016 Sep;73(9):573-81. doi: 10.1136/oemed-2015-103086. Epub 2016 May 24.
[360] Jacobs M, Zhang G, ... Pereira G. The association between ambient air pollution and selected adverse pregnancy outcomes in China: A systematic review. Sci Total Environ. 2017 Feb 1;579:1179-1192. doi: 10.1016/j.scitotenv.2016.11.100. Epub 2016 Nov 29.
[361] Carré J, Gatimel N,... Léandri R. Does air pollution play a role in infertility?: a systematic review. Environ Health. 2017 Jul 28;16(1):82. doi: 10.1186/s12940-017-0291-8.
[362] Shah PS, Balkhair T; Knowledge Synthesis Group on Determinants of Preterm/LBW births. Air pollution and birth outcomes: a systematic review. Environ Int. 2011 Feb;37(2):498-516. doi: 10.1016/j.envint.2010.10.009. Epub 2010 Nov 26.
[363] Woodford DM, Coutu RE, Gaensler EA. Obstructive lung disease from acute sulfur dioxide exposure. Respiration. 1979;38(4):238-45.
[364] Osterman JW, Greaves IA, ... Thériault G. Respiratory symptoms associated with low level sulphur dioxide exposure in silicon carbide production workers. Br J Ind Med. 1989 Sep;46(9):629-35.
[365] Li X, Yi H, Wang H. Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice. Ecotoxicol Environ Saf. 2018 Dec 15;165:164-173. doi: 10.1016/j.ecoenv.2018.08.109. Epub 2018 Sep 5.
[366] Zhang J, Zheng F, ... Wang J. Sulfur dioxide inhalation lowers sperm quality and alters testicular histology via increasing expression of CREM and ACT proteins in rat testes. Environ Toxicol Pharmacol. 2016 Oct;47:47-52. doi: 10.1016/j.etap.2016.09.001. Epub 2016 Sep 4.
[367] Meng Z, Bai W. Oxidation damage of sulfur dioxide on testicles of mice. Environ Res. 2004 Nov;96(3):298-304.
[368] An JL, Wang YS, Li X, Sun Y, Shen SH. Relationship between surface UV radiation and air pollution in Beijing. Huan Jing Ke Xue. 2008 Apr;29(4):1053-8.
[369] Hoseinzadeh E, Taha P, ... Miri M. The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency. Food Chem Toxicol. 2018 Mar;113:241-254. doi: 10.1016/j.fct.2018.01.052. Epub 2018 Feb 1.
[370] Liu J, Zhang W. The influence of the environment and clothing on human exposure to ultraviolet light. PLoS One. 2015 Apr 29;10(4):e0124758. doi: 10.1371/journal.pone.0124758. eCollection 2015.
[371] Barrea L, Savastano S, ... Colao A. Low serum vitamin D-status, air pollution and obesity: A dangerous liaison. Rev Endocr Metab Disord. 2017 Jun;18(2):207-214. doi: 10.1007/s11154-016-9388-6.
[372] Hosseinpanah F, Pour SH, ... Azizi F. The effects of air pollution on vitamin D status in healthy women: a cross sectional study. BMC Public Health. 2010 Aug 29;10:519. doi: 10.1186/1471-2458-10-519.
[373] Siddens LK, Larkin A, ...Baird WM. Polycyclic aromatic hydrocarbons as skin carcinogens: comparison of benzo[a]pyrene, dibenzo[def,p]chrysene and three environmental mixtures in the FVB/N mouse. Toxicol Appl Pharmacol. 2012 Nov 1;264(3):377-86. doi: 10.1016/j.taap.2012.08.014. Epub 2012 Aug 23.
[374] Satarug S, Moore MR. Adverse health effects of chronic exposure to low-level cadmium in foodstuffs and cigarette smoke. Environ Health Perspect. 2004 Jul;112(10):1099-103.
[375] Nawrot T, Plusquin M, ... Staessen JA. Environmental exposure to cadmium and risk of cancer: a prospective population-based study. Lancet Oncol. 2006 Feb;7(2):119-26.
[376] Exercise and air quality: 10 top tips. Breathe (Sheff). 2015 Sep;11(3):239-42. doi: 10.1183/20734735.ELF113.
[377] WHO Europe. Review of evidence on health aspects of air pollution – REVIHAAP Project: Technical Report. Proximity to roads, NO2, other air pollutants and their mixtures
[378] Barnes NM, Ng TW, Ma KK, Lai KM. In-Cabin Air Quality during Driving and Engine Idling in Air-Conditioned Private Vehicles in Hong Kong. Int J Environ Res Public Health. 2018 Mar 27;15(4). pii: E611. doi: 10.3390/ijerph15040611.
[379] Zhang K, Batterman S. Air pollution and health risks due to vehicle traffic. Sci Total Environ. 2013 Apr 15;450-451:307-16. doi: 10.1016/j.scitotenv.2013.01.074.
[380] Moreno T, Reche C, ... Gibbons W. Urban air quality comparison for bus, tram, subway and pedestrian commutes in Barcelona. Environ Res. 2015 Oct;142:495-510. doi: 10.1016/j.envres.2015.07.022. Epub 2015 Aug 13.
[381] Chaney RA, Sloan CD, ... Johnston JD. Personal exposure to fine particulate air pollution while commuting: An examination of six transport modes on an urban arterial roadway. PLoS One. 2017 Nov 9;12(11):e0188053. doi: 10.1371/journal.pone.0188053. eCollection 2017.
[382] Weng M, Jin X. Study on the air pollution in typical transportation microenvironment: Characteristics and health risks. J Air Waste Manag Assoc. 2015 Jan;65(1):59-63. doi: 10.1080/10962247.2014.962648.
[383] Nasir ZA, Colbeck I. Particulate air pollution in transport micro-environments. J Environ Monit. 2009 Jun;11(6):1140-6. doi: 10.1039/b821824b. Epub 2009 Apr 8.
[384] Riediker M. Cardiovascular effects of fine particulate matter components in highway patrol officers. Inhal Toxicol. 2007;19 Suppl 1:99-105.
[385] Riediker M, Devlin RB, ... Cascio WE. Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions. Part Fibre Toxicol. 2004 Dec 9;1(1):2.
[386] Barrea L, Savastano S, ... Colao A. Low serum vitamin D-status, air pollution and obesity: A dangerous liaison. Rev Endocr Metab Disord. 2017 Jun;18(2):207-214. doi: 10.1007/s11154-016-9388-6.
[387] Liu J, Zhang W. The influence of the environment and clothing on human exposure to ultraviolet light. PLoS One. 2015 Apr 29;10(4):e0124758. doi: 10.1371/journal.pone.0124758. eCollection 2015.
[388] Hoseinzadeh E, Taha P, ... Miri M. The impact of air pollutants, UV exposure and geographic location on vitamin D deficiency. Food Chem Toxicol. 2018 Mar;113:241-254. doi: 10.1016/j.fct.2018.01.052. Epub 2018 Feb 1.
[389] An JL, Wang YS, Li X, Sun Y, Shen SH. Relationship between surface UV radiation and air pollution in Beijing. Huan Jing Ke Xue. 2008 Apr;29(4):1053-8.
[390] Ng TP, Seet CS, Tan WC, Foo SC. Nitrogen dioxide exposure from domestic gas cooking and airway response in asthmatic women. Thorax. 2001 Aug;56(8):596-601.
[391] Nicole W. Cooking up indoor air pollution: emissions from natural gas stoves. Environ Health Perspect. 2014 Jan;122(1):A27. doi: 10.1289/ehp.122-A27.
[392] Eisner MD, Blanc PD. Gas stove use and respiratory health among adults with asthma in NHANES III. Occup Environ Med. 2003 Oct;60(10):759-64.
[393] Luczynska CM, Li Y, Chapman MD, Platts-Mills TA. Airborne concentrations and particle size distribution of allergen derived from domestic cats (Felis domesticus). Measurements using cascade impactor, liquid impinger, and a two-site monoclonal antibody assay for Fel d I. m Rev Respir Dis. 1990 Feb;141(2):361-7.
[394] Péter S, Holguin F, ... Eggersdorfer M. Nutritional Solutions to Reduce Risks of Negative Health Impacts of Air Pollution. Nutrients. 2015 Dec 10;7(12):10398-416. doi: 10.3390/nu7125539.
[395] Romieu I, Téllez-Rojo MM, ... Holguin F. Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter. Am J Respir Crit Care Med. 2005 Dec 15;172(12):1534-40. Epub 2005 Oct 6.
[396] Romieu I, Castro-Giner F, Kunzli N, Sunyer J. Air pollution, oxidative stress and dietary supplementation: a review. Eur Respir J. 2008 Jan;31(1):179-97. doi: 10.1183/09031936.00128106.
[397] Hennig B, Ettinger AS, ... Suk WA. Using nutrition for intervention and prevention against environmental chemical toxicity and associated diseases. Environ Health Perspect. 2007 Apr;115(4):493-5. Epub 2007 Jan 16.
[398] Whyand T, Hurst JR, Beckles M, Caplin ME. Pollution and respiratory disease: can diet or supplements help? A review. Respir Res. 2018 May 2;19(1):79. doi: 10.1186/s12931-018-0785-0.
[399] Ou CQ, Wong CM, ... Lam TH. Dietary habits and the short-term effects of air pollution on mortality in the Chinese population in Hong Kong. J Epidemiol Community Health. 2012 Mar;66(3):254-8. doi: 10.1136/jech.2009.103275. Epub 2010 Sep 30.
[400] Schulz AJ, Mentz GB, ... Izumi B. Effects of particulate matter and antioxidant dietary intake on blood pressure. Am J Public Health. 2015 Jun;105(6):1254-61. doi: 10.2105/AJPH.2014.302176. Epub 2014 Oct 16.
[401] Kelly FJ, Fussell JC. Linking ambient particulate matter pollution effects with oxidative biology and immune responses. Ann N Y Acad Sci. 2015 Mar;1340:84-94. doi: 10.1111/nyas.12720. Epub 2015 Feb 25.
[402] Nel AE, Diaz-Sanchez D, Li N. The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress. Curr Opin Pulm Med. 2001 Jan;7(1):20-6.
[403] Peters A, von Klot S,... Cooperative Health Research in the Region of Augsburg Study Group. Exposure to traffic and the onset of myocardial infarction. N Engl J Med. 2004 Oct 21;351(17):1721-30.
[404] Poljšak B, Fink R. The protective role of antioxidants in the defence against ROS/RNS-mediated environmental pollution. Oxid Med Cell Longev. 2014;2014:671539. doi: 10.1155/2014/671539. Epub 2014 Jul 20.
[405] Romieu I, Garcia-Esteban R, ... Holguin F. The effect of supplementation with omega-3 polyunsaturated fatty acids on markers of oxidative stress in elderly exposed to PM(2.5). Environ Health Perspect. 2008 Sep;116(9):1237-42. doi: 10.1289/ehp.10578.
[406] Kelly FJ. Dietary antioxidants and environmental stress. Proc Nutr Soc. 2004 Nov;63(4):579-85.
[407] Tong H, Rappold AG, ... Samet JM. Omega-3 fatty acid supplementation appears to attenuate particulate air pollution-induced cardiac effects and lipid changes in healthy middle-aged adults. Environ Health Perspect. 2012 Jul;120(7):952-7. doi: 10.1289/ehp.1104472. Epub 2012 Apr 19.
[408] Baccarelli A, Cassano PA, ... Schwartz J. Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms. Circulation. 2008 Apr 8;117(14):1802-9. doi: 10.1161/CIRCULATIONAHA.107.726067. Epub 2008 Mar 31.
[409] Heber D, Li Z, Garcia-Lloret M, ... Zhang Y, Nel A. Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles. Food Funct. 2014 Jan;5(1):35-41. doi: 10.1039/c3fo60277j.
[410] Egner PA, Chen JG, ... Kensler TW. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.
[411] Manicourt DH, Devogelaer JP. Urban tropospheric ozone increases the prevalence of vitamin D deficiency among Belgian postmenopausal women with outdoor activities during summer. J Clin Endocrinol Metab. 2008 Oct;93(10):3893-9. doi: 10.1210/jc.2007-2663. Epub 2008 Jul 15.
[412] Agarwal KS, Mughal MZ, ... Puliyel JM. The impact of atmospheric pollution on vitamin D status of infants and toddlers in Delhi, India. Arch Dis Child. 2002 Aug;87(2):111-3.
[413] Hosseinpanah F, Pour SH, ... Azizi F. The effects of air pollution on vitamin D status in healthy women: a cross sectional study. BMC Public Health. 2010 Aug 29;10:519. doi: 10.1186/1471-2458-10-519.
[414] Macintosh DL, Minegishi T, ... Myatt TA. The benefits of whole-house in-duct air cleaning in reducing exposures to fine particulate matter of outdoor origin: a modeling analysis. J Expo Sci Environ Epidemiol. 2010 Mar;20(2):213-24. doi: 10.1038/jes.2009.16. Epub 2009 Mar 25.
[415] Lovett-Racke AE, Racke MK. Retinoic acid promotes the development of Th2-like human myelin basic protein-reactive T cells. Cell Immunol. 2002 Jan;215(1):54-60.
[416] Mancebo SE, Wang SQ. Recognizing the impact of ambient air pollution on skin health. J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2326-32. doi: 10.1111/jdv.13250. Epub 2015 Aug 20.
[417] Vierkötter A, Schikowski T, ...Krutmann J. Airborne particle exposure and extrinsic skin aging. J Invest Dermatol. 2010 Dec;130(12):2719-26. doi: 10.1038/jid.2010.204. Epub 2010 Jul 22.
[418] Meng QY, Spector D, Colome S, Turpin B. Determinants of Indoor and Personal Exposure to PM(2.5) of Indoor and Outdoor Origin during the RIOPA Study. Atmos Environ (1994). 2009 Nov;43(36):5750-5758.
[419] Huang YL, Chen HW, ... Chuang KJ. Personal exposure to household particulate matter, household activities and heart rate variability among housewives. PLoS One. 2014 Mar 3;9(3):e89969. doi: 10.1371/journal.pone.0089969. eCollection 2014.
[420] Macintosh DL, Myatt TA ... Spengler JD. Whole house particle removal and clean air delivery rates for in-duct and portable ventilation systems. J Air Waste Manag Assoc. 2008 Nov;58(11):1474-82.
[421] Macintosh DL, Minegishi T, ... Myatt TA. The benefits of whole-house in-duct air cleaning in reducing exposures to fine particulate matter of outdoor origin: a modeling analysis. J Expo Sci Environ Epidemiol. 2010 Mar;20(2):213-24. doi: 10.1038/jes.2009.16. Epub 2009 Mar 25.
[422] Daigle CC, Chalupa DC, ... Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol. 2003 May;15(6):539-52.
[423] Bennett WD, Zeman KL, Jarabek AM. Nasal contribution to breathing and fine particle deposition in children versus adults. J Toxicol Environ Health A. 2008;71(3):227-37.
[424] Campbell ME, Li Q, ... Cheng S. Should people be physically active outdoors on smog alert days? Can J Public Health. 2005 Jan-Feb;96(1):24-8.
[425] Warburton DE, Nicol CW, Bredin S. Health benefits of physical activity: the evidence. CMAJ. 2006 Mar 14;174(6):801-9.
[426] Hartog JJ, Boogaard H, Nijland H, Hoek G. Do the health benefits of cycling outweigh the risks? Cien Saude Colet. 2011 Dec;16(12):4731-44.
[427] Rojas-Rueda D, de Nazelle A, Teixidó O, Nieuwenhuijsen MJ. Replacing car trips by increasing bike and public transport in the greater Barcelona metropolitan area: a health impact assessment study. Environ Int. 2012 Nov 15;49:100-9. doi: 10.1016/j.envint.2012.08.009. Epub 2012 Sep 21.
[428] Tainio M, de Nazelle AJ, ... Woodcock J. Can air pollution negate the health benefits of cycling and walking? Prev Med. 2016 Jun;87:233-236. doi: 10.1016/j.ypmed.2016.02.002. Epub 2016 May 5.
[429] Zuurbier M, Hoek G, ... Brunekreef B. Commuters' exposure to particulate matter air pollution is affected by mode of transport, fuel type, and route. Environ Health Perspect. 2010 Jun;118(6):783-9. doi: 10.1289/ehp.0901622. Epub 2010 Feb 25.
[430] Hudda N, Kostenidou E, Sioutas C, Delfino RJ, Fruin SA. Vehicle and driving characteristics that influence in-cabin particle number concentrations. Environ Sci Technol. 2011 Oct 15;45(20):8691-7. doi: 10.1021/es202025m. Epub 2011 Sep 19.
[431] Langrish JP, Mills NL ... Jiang L. Beneficial cardiovascular effects of reducing exposure to particulate air pollution with a simple facemask. Part Fibre Toxicol. 2009 Mar 13;6:8. doi: 10.1186/1743-8977-6-8.
[432] Langrish JP, Li X, Wang S, ... Jiang L. Reducing personal exposure to particulate air pollution improves cardiovascular health in patients with coronary heart disease. Environ Health Perspect. 2012 Mar;120(3):367-72. doi: 10.1289/ehp.1103898.
[433] Jones JG. The physiological cost of wearing a disposable respirator. Am Ind Hyg Assoc J. 1991 Jun;52(6):219-25.
[434] Hussain S, Laumbach R, ... Kipen H. Controlled exposure to diesel exhaust causes increased nitrite in exhaled breath condensate among subjects with asthma. J Occup Environ Med. 2012 Oct;54(10):1186-91. doi: 10.1097/JOM.0b013e31826bb64c
[435] Wright RJ, Brunst KJ. Programming of respiratory health in childhood: influence of outdoor air pollution. v
[436] Backes CH, Nelin T, Gorr MW, Wold LE. Early life exposure to air pollution: how bad is it? Toxicol Lett. 2013 Jan 10;216(1):47-53. doi: 10.1016/j.toxlet.2012.11.007. Epub 2012 Nov 16.
[437] Bell ML, Zanobetti A, Dominici F. Evidence on vulnerability and susceptibility to health risks associated with short-term exposure to particulate matter: a systematic review and meta-analysis. Am J Epidemiol. 2013 Sep 15;178(6):865-76. doi: 10.1093/aje/kwt090. Epub 2013 Jul 25.
[438] Chen Z, Salam MT, .... Gilliland FD. Chronic effects of air pollution on respiratory health in Southern California children: findings from the Southern California Children's Health Study. J Thorac Dis. 2015 Jan;7(1):46-58. doi: 10.3978/j.issn.2072-1439.2014.12.20.
[439] Brook RD, Rajagopalan S, ... Kaufman JD. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation. 2010 Jun 1;121(21):2331-78. doi: 10.1161/CIR.0b013e3181dbece1. Epub 2010 May 10.
[440] Klingberg J, Broberg M, ... Pleijel H. Influence of urban vegetation on air pollution and noise exposure - A case study in Gothenburg, Sweden. Sci Total Environ. 2017 Dec 1;599-600:1728-1739. doi: 10.1016/j.scitotenv.2017.05.051. Epub 2017 May 20.
[441] Setälä H, Viippola V, ... Yli-Pelkonen V. Does urban vegetation mitigate air pollution in northern conditions? Environ Pollut. 2013 Dec;183:104-12. doi: 10.1016/j.envpol.2012.11.010. Epub 2012 Dec 27.
[442] Vos PE, Maiheu B, Vankerkom J, Janssen S. Improving local air quality in cities: to tree or not to tree? Environ Pollut. 2013 Dec;183:113-22. doi: 10.1016/j.envpol.2012.10.021. Epub 2012 Nov 27.
[443] Gourdji S. Review of plants to mitigate particulate matter, ozone as well as nitrogen dioxide air pollutants and applicable recommendations for green roofs in Montreal, Quebec. Environ Pollut. 2018 Oct;241:378-387. doi: 10.1016/j.envpol.2018.05.053. Epub 2018 May 28.
[444] Przybysz A, Sæbø A, Hanslin HM, Gawroński SW. Accumulation of particulate matter and trace elements on vegetation as affected by pollution level, rainfall and the passage of time. Sci Total Environ. 2014 May 15;481:360-9. doi: 10.1016/j.scitotenv.2014.02.072. Epub 2014 Mar 7.
[445] Wang H, Shi H, Wang Y. Effects of weather, time, and pollution level on the amount of particulate matter deposited on leaves of Ligustrum lucidum. ScientificWorldJournal. 2015;2015:935942. doi: 10.1155/2015/935942. Epub 2015 Jan 1.
[446] Sæbø A, Popek R, ... Gawronski SW. Plant species differences in particulate matter accumulation on leaf surfaces. Sci Total Environ. 2012 Jun 15;427-428:347-54. doi: 10.1016/j.scitotenv.2012.03.084. Epub 2012 May 2.
[447] Liang D, Ma C, Wang YQ, Wang YJ, Chen-Xi Z. Quantifying PM2.5 capture capability of greening trees based on leaf factors analyzing. Environ Sci Pollut Res Int. 2016 Nov;23(21):21176-21186. Epub 2016 Sep 19.
[448] Nguyen T, Yu X, Zhang Z, Liu M, Liu X. Relationship between types of urban forest and PM2.5 capture at three growth stages of leaves. J Environ Sci (China). 2015 Jan 1;27:33-41. doi: 10.1016/j.jes.2014.04.019. Epub 2014 Dec 3.
[449] Weerakkody U, Dover JW, Mitchell P, Reiling K. Quantification of the traffic-generated particulate matter capture by plant species in a living wall and evaluation of the important leaf characteristics. Sci Total Environ. 2018 Sep 1;635:1012-1024. doi: 10.1016/j.scitotenv.2018.04.106. Epub 2018 Apr 24.
[450] Mo L, Ma Z, ... Yu X. Assessing the Capacity of Plant Species to Accumulate Particulate Matter in Beijing, China. PLoS One. 2015 Oct 27;10(10):e0140664. doi: 10.1371/journal.pone.0140664. eCollection 2015.
[451] Chen J, Yu X, Bi H, Fu Y. Indoor simulations reveal differences among plant species in capturing particulate matter. PLoS One. 2017 May 16;12(5):e0177539. doi: 10.1371/journal.pone.0177539. eCollection 2017.
[452] Zhang T, Bai Y, Hong X, Sun L, Liu Y. Particulate matter and heavy metal deposition on the leaves of Euonymus japonicus during the East Asian monsoon in Beijing, China. PLoS One. 2017 Jun 29;12(6):e0179840. doi: 10.1371/journal.pone.0179840. eCollection 2017.
[453] Neu J, Rushing J. Cesarean versus vaginal delivery: long-term infant outcomes and the hygiene hypothesis. Clin Perinatol. 2011 Jun;38(2):321-31. doi: 10.1016/j.clp.2011.03.008.
[454] Mueller NT, Bakacs E, ... Dominguez-Bello MG. The infant microbiome development: mom matters. Trends Mol Med. 2015 Feb;21(2):109-17. doi: 10.1016/j.molmed.2014.12.002. Epub 2014 Dec 11.
[455] Strachan DP. Family size, infection and atopy: the first decade of the "hygiene hypothesis". Thorax. 2000 Aug;55 Suppl 1:S2-10.
[456] van Neerven RJ, Knol EF, Heck JM, Savelkoul HF. Which factors in raw cow's milk contribute to protection against allergies? J Allergy Clin Immunol. 2012 Oct;130(4):853-8. doi: 10.1016/j.jaci.2012.06.050. Epub 2012 Aug 30.
[457] Hodgkinson AJ, McDonald NA, Hine B. Effect of raw milk on allergic responses in a murine model of gastrointestinal allergy. Br J Nutr. 2014 Aug 14;112(3):390-7. doi: 10.1017/S0007114514001044. Epub 2014 May 29.
[458] Wolfe ND, Dunavan CP, Diamond J. Origins of major human infectious diseases. Nature. 2007 May 17;447(7142):279-83.
[459] Sironi M, Clerici M. The hygiene hypothesis: an evolutionary perspective. Microbes Infect. 2010 Jun;12(6):421-7. doi: 10.1016/j.micinf.2010.02.002. Epub 2010 Feb 21.
[460] Zock JP1, Plana E, ... Kogevinas M. The use of household cleaning sprays and adult asthma: an international longitudinal study. Am J Respir Crit Care Med. 2007 Oct 15;176(8):735-41. Epub 2007 Jun 21.
[461] Gibson PG, Henry RL, ... Wang H. Migration to a western country increases asthma symptoms but not eosinophilic airway inflammation. Pediatr Pulmonol. 2003 Sep;36(3):209-15.
[462] Wolkoff P. Indoor air humidity, air quality, and health - An overview. Int J Hyg Environ Health. 2018 Apr;221(3):376-390. doi: 10.1016/j.ijheh.2018.01.015. Epub 2018 Jan 31.
[463] Arundel AV, Sterling EM, Biggin JH, Sterling TD. Indirect health effects of relative humidity in indoor environments. Environ Health Perspect. 1986 Mar;65:351-61.
[464] Fang L, Clausen G, Fanger PO. Impact of temperature and humidity on chemical and sensory emissions from building materials. Indoor Air. 1999 Sep;9(3):193-201.
[465] Wolkoff P, Kjaergaard SK. The dichotomy of relative humidity on indoor air quality. Environ Int. 2007 Aug;33(6):850-7. Epub 2007 May 17.
[466] Bluyssen PM, Roda C,... Bartzis J. Self-reported health and comfort in 'modern' office buildings: first results from the European OFFICAIR study. Indoor Air. 2016 Apr;26(2):298-317. doi: 10.1111/ina.12196. Epub 2015 Mar 14.
[467] Brightman HS, Milton DK, ... Spengler JD. Evaluating building-related symptoms using the US EPA BASE study results. Indoor Air. 2008 Aug;18(4):335-45. doi: 10.1111/j.1600-0668.2008.00557.x.
[468] Angelon-Gaetz KA, Richardson DB, Marshall SW, Hernandez ML. Exploration of the effects of classroom humidity levels on teachers' respiratory symptoms. Int Arch Occup Environ Health. 2016 Jul;89(5):729-37. doi: 10.1007/s00420-016-1111-0. Epub 2016 Jan 27.
[469] Azuma K, Ikeda K, Kagi N, Yanagi U, Osawa H. Prevalence and risk factors associated with nonspecific building-related symptoms in office employees in Japan: relationships between work environment, Indoor Air Quality, and occupational stress. Indoor Air. 2015 Oct;25(5):499-511. doi: 10.1111/ina.12158. Epub 2014 Oct 24.
[470] Azuma K, Ikeda K, Kagi N, Yanagi U, Osawa H. Evaluating prevalence and risk factors of building-related symptoms among office workers: Seasonal characteristics of symptoms and psychosocial and physical environmental factors. Environ Health Prev Med. 2017 Apr 12;22(1):38. doi: 10.1186/s12199-017-0645-4.
[472] Lukcso D, Guidotti TL, Franklin DE, Burt A. Indoor environmental and air quality characteristics, building-related health symptoms, and worker productivity in a federal government building complex. Arch Environ Occup Health. 2016;71(2):85-101. doi: 10.1080/19338244.2014.965246. Epub 2014 Sep 25.
[473] Reinikainen LM, Jaakkola JJ. Significance of humidity and temperature on skin and upper airway symptoms. Indoor Air. 2003 Dec;13(4):344-52.
[474] Markowicz P, Larsson L. Influence of relative humidity on VOC concentrations in indoor air. Environ Sci Pollut Res Int. 2015 Apr;22(8):5772-9. doi: 10.1007/s11356-014-3678-x. Epub 2014 Oct 28.
[475] Huang S, Xiong J, Cai C, Xu W, Zhang Y. Influence of humidity on the initial emittable concentration of formaldehyde and hexaldehyde in building materials: experimental observation and correlation. Sci Rep. 2016 Mar 30;6:23388. doi: 10.1038/srep23388.
[476] Kang J, Liu J, Pei J. The indoor volatile organic compound (VOC) characteristics and source identification in a new university campus in Tianjin, China. J Air Waste Manag Assoc. 2017 Jun;67(6):725-737. doi: 10.1080/10962247.2017.1280561. Epub 2017 Feb 2.
[477] Chin JY, Godwin C,... Batterman S. Levels and sources of volatile organic compounds in homes of children with asthma. Indoor Air. 2014 Aug;24(4):403-15. doi: 10.1111/ina.12086. Epub 2014 Jan 13.
[478] McDonald BC, de Gouw JA, ... Trainer M. Volatile chemical products emerging as largest petrochemical source of urban organic emissions. Science. 2018 Feb 16;359(6377):760-764. doi: 10.1126/science.aaq0524.
[479] Potera C. Scented products emit a bouquet of VOCs. Environ Health Perspect. 2011 Jan;119(1):A16. doi: 10.1289/ehp.119-a16.
[480] LeBouf RF, Virji MA, ... Stefaniak AB. Exposure to volatile organic compounds in healthcare settings. Occup Environ Med. 2014 Sep;71(9):642-50. doi: 10.1136/oemed-2014-102080. Epub 2014 Jul 10.
[481] An JY, Kim S, Kim HJ. Formaldehyde and TVOC emission behavior of laminate flooring by structure of laminate flooring and heating condition. J Hazard Mater. 2011 Mar 15;187(1-3):44-51. doi: 10.1016/j.jhazmat.2010.08.086. Epub 2010 Aug 27.
[482] Hong SH, Hong J, Yu J, Lim Y. Study of the removal difference in indoor particulate matter and volatile organic compounds through the application of plants. Environ Health Toxicol. 2017 Feb 22;32:e2017006. doi: 10.5620/eht.e2017006. eCollection 2017.
[483] Dela Cruz M, Christensen JH, Thomsen JD, Müller R. Can ornamental potted plants remove volatile organic compounds from indoor air? A review. Environ Sci Pollut Res Int. 2014 Dec;21(24):13909-28. doi: 10.1007/s11356-014-3240-x. Epub 2014 Jul 25.
[484] Papinchak HL, Holcomb EJ, ... Decoteau DR. Effectiveness of Houseplants in Reducing the Indoor Air Pollutant Ozone. HortTechnology 2009 19(2): 286-290.
[485] Orwell RL, Wood RL, ... Burchett MD. Removal of Benzene by the Indoor Plant/Substrate Microcosm and Implications for Air Quality. Water, Air, and Soil Pollution 2004 157 (1–4): 193–207.
[486] Kim HH, Yang JY, ... Lim YW. House-plant placement for indoor air purification and health benefits on asthmatics. Environ Health Toxicol. 2014 Oct 8;29:e2014014. doi: 10.5620/eht.e2014014. eCollection 2014.
[487] Gawrońska H, Bakera B. Phytoremediation of particulate matter from indoor air by Chlorophytum comosum L. plants. Air Qual Atmos Health. 2015;8(3):265-272. Epub 2014 Aug 9.
[488] Brilli F, Fares S, ... Menghini F. Plants for Sustainable Improvement of Indoor Air Quality. Trends Plant Sci. 2018 Jun;23(6):507-512. doi: 10.1016/j.tplants.2018.03.004. Epub 2018 Apr 19.
[489] Yang DS, Pennisi SV, ... Kays SJ. Screening indoor plants for volatile organic pollutant removal efficiency. HortScience August 2009 44(5): 1377-1381.
[490] Xu Z, Wang L, Hou H. Formaldehyde removal by potted plant-soil systems. J Hazard Mater. 2011 Aug 15;192(1):314-8. doi: 10.1016/j.jhazmat.2011.05.020. Epub 2011 May 17.
[491] Feng Q, Zhang H, Dong Z, Zhou Y, Ma J. Circulating 25-hydroxyvitamin D and lung cancer risk and survival: A dose-response meta-analysis of prospective cohort studies. Medicine (Baltimore). 2017 Nov;96(45):e8613. doi: 10.1097/MD.0000000000008613.
[492] Liu J, Dong Y, ... Zhao Q. Meta-analysis of the correlation between vitamin D and lung cancer risk and outcomes. Oncotarget. 2017 Jun 28;8(46):81040-81051. doi: 10.18632/oncotarget.18766. eCollection 2017 Oct 6.
[493] Martineau AR, Cates CJ, ... Griffiths CJ. Vitamin D for the management of asthma. Cochrane Database Syst Rev. 2016 Sep 5;9:CD011511. doi: 10.1002/14651858.CD011511.pub2.
[494] Brehm JM, Schuemann B, ... Childhood Asthma Management Program Research Group. Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol. 2010 Jul;126(1):52-8.e5. doi: 10.1016/j.jaci.2010.03.043. Epub 2010 Jun 9.
[495] Gupta A, Sjoukes A, ... Saglani S. Relationship between serum vitamin D, disease severity, and airway remodeling in children with asthma. Am J Respir Crit Care Med. 2011 Dec 15;184(12):1342-9. doi: 10.1164/rccm.201107-1239OC. Epub 2011 Sep 8.
[496] Bourdrel T, Bind MA, ... Argacha JF. Cardiovascular effects of air pollution. Arch Cardiovasc Dis. 2017 Nov;110(11):634-642. doi: 10.1016/j.acvd.2017.05.003. Epub 2017 Jul 21.
[497] Rennolds J, Malireddy S, ... Cormet-Boyaka E. Curcumin regulates airway epithelial cell cytokine responses to the pollutant cadmium. Biochem Biophys Res Commun. 2012 Jan 6;417(1):256-61. doi: 10.1016/j.bbrc.2011.11.096. Epub 2011 Nov 28.
[498] Ng TP, Niti M, ... Tan WC. Curcumins-rich curry diet and pulmonary function in Asian older adults. PLoS One. 2012;7(12):e51753. doi: 10.1371/journal.pone.0051753. Epub 2012 Dec 26.
[499] Panahi Y, Ghanei M, Hajhashemi A, Sahebkar A. Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial. J Diet Suppl. 2016;13(1):93-105. doi: 10.3109/19390211.2014.952865. Epub 2014 Aug 29.
[500] Snow SJ, Cheng WY, ... Kodavanti UP. Ozone-Induced Vascular Contractility and Pulmonary Injury Are Differentially Impacted by Diets Enriched With Coconut Oil, Fish Oil, and Olive Oil. Toxicol Sci. 2018 May 1;163(1):57-69. doi: 10.1093/toxsci/kfy003.
[501] Romieu I, Barraza-Villarreal A, ... Del Rio-Navarro BE. Dietary intake, lung function and airway inflammation in Mexico City school children exposed to air pollutants. Respir Res. 2009 Dec 10;10:122. doi: 10.1186/1465-9921-10-122.
[502] Mehta AK, Singh BP, Arora N, Gaur SN. Choline attenuates immune inflammation and suppresses oxidative stress in patients with asthma. Immunobiology. 2010 Jul;215(7):527-34. doi: 10.1016/j.imbio.2009.09.004. Epub 2009 Nov 7.
[503] Detopoulou P, Panagiotakos DB, ... Stefanadis C. Dietary choline and betaine intakes in relation to concentrations of inflammatory markers in healthy adults: the ATTICA study. Am J Clin Nutr. 2008 Feb;87(2):424-30.
[504] Orecchio S, Fiore M, ... Vara G. Volatile Profiles of Emissions from Different Activities Analyzed Using Canister Samplers and Gas Chromatography-Mass Spectrometry (GC/MS) Analysis: A Case Study. Int J Environ Res Public Health. 2017 Feb 15;14(2). pii: E195. doi: 10.3390/ijerph14020195.
[505] Shi J, Lin Z, ... Kan H. Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial. Environ Health Perspect. 2017 Feb;125(2):175-180. doi: 10.1289/EHP73. Epub 2016 Aug 26.
[506] Shi J, Lin Z, ... Kan H. Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial. Environ Health Perspect. 2017 Feb;125(2):175-180. doi: 10.1289/EHP73. Epub 2016 Aug 26.
[507] Morishita M, Thompson KC, Brook RD. Understanding Air Pollution and Cardiovascular Diseases: Is It Preventable? Curr Cardiovasc Risk Rep. 2015 Jun;9(6). pii: 30.
[508] Suhaimi MM, Leman AM, ... Gani P. Effectiveness of Indoor Plant to Reduce CO2 in Indoor Environment. MATEC Web of Conferences 103, 2017.
[509] Homo habilis reconstruction in the Museo de la Evolución Humana, Burgos, sculpture by Elisabeth Daynes (2010) based on the KNM-ER 1813 cranium (Koobi Fora, Kenya, dated 1.9 Ma). CC 4.0 lisence. Source: WikiPedia Homo habilis article. Change made to file name.
[510] Bloch C. Early Concepts in Investigative Practice— The Case of the Virus. In: Scientific Concepts and Investigative Practice, Feest, U, Steinle F. De Gruyter, 2012, 191-218.
[511] World Health Organization. WHO Training Package for the Health Sector: Children's Health and the Environment, 2008.
[512] Leung DYC. Outdoor-indoor air pollution in urban environment: Challenges and opportunity. 2015
[513] Chen C, Zhao B. Review of relationship between indoor and outdoor particles: I/O ratio, infiltration factor and penetration factor. Atmospheric Environment 45(2) 2011: 275-288.
[514] Papathanasopoulos P, Preka-Papadema P, ... Kargiotis O. The possible effects of the solar and geomagnetic activity on multiple sclerosis.Clin Neurol Neurosurg. 2016 Jul;146:82-9. doi: 10.1016/j.clineuro.2016.04.023. Epub 2016 Apr 27.
[515] Alabdulgader A, McCraty R. Long-Term Study of Heart Rate Variability Responses to Changes in the Solar and Geomagnetic Environment. Nature 8 2018.
[516] Milojević S. Revisiting the connection between Solar eruptions and primary headaches and migraines using Twitter. Sci Rep. 2016 Dec 23;6:39769. doi: 10.1038/srep39769.
[517] Close J. Are stress responses to geomagnetic storms mediated by the cryptochrome compass system? Proc Biol Sci. 2012 Jun 7;279(1736):2081-90. doi: 10.1098/rspb.2012.0324. Epub 2012 Mar 14.
[518] Sustainable Development Goal Indicator 3.9.1. WHO.
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